Disease susceptibility risk prediction method and device

A risk prediction and disease technology, applied in the field of bioinformatics, can solve the problem of low referenceability of prediction data

Active Publication Date: 2015-11-18
上海尔云信息科技有限公司
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Problems solved by technology

Currently known individual disease susceptibility risk calculation methods are only based on the single nucleotide polymorphism changes of individual chromosome loci, which overemphasizes the importance of genetic informati

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  • Disease susceptibility risk prediction method and device
  • Disease susceptibility risk prediction method and device

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Embodiment Construction

[0028] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.

[0029] In addition, it should be understood that one or more method steps mentioned in the present invention do not exclude that there may be other method steps before and after the combined steps or other method steps may be inserted between these explicitly mentioned steps, unless otherwise There are descriptions; it should also be understood that the combined connection relationship between one or more devices / devices mentioned in the presen...

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Abstract

The invention relates to bioinformatics and provides a disease susceptibility risk prediction method and device. The disease susceptibility risk prediction method comprises the steps: providing a database including disease morbidity data, SNP locus genotype frequency data, and risk allele homozygous and heterozygous genotype OR value data aiming at each disease-associated SNP locus; receiving information of a to-be-predicted individual; calculating to obtain a comprehensive disease susceptibility risk array of diseases interested by the to-be-predicted individual; and generating a comprehensive disease susceptibility risk dynamic change curve of the individual in an appointed age range. According to the disease susceptibility risk prediction method and device, two factors , including individual inheritance and environment factors, are considered at the same time when the disease susceptibility risk of an individual is calculated, so that calculating results greatly conform to objective reality; according to the obtained disease susceptibility risk age change curve of the individual, the individual not only can learn more precise immediate disease susceptibility risk, but also can continuously understand the susceptibility change tendency of various diseases along with the growth of age.

Description

technical field [0001] The invention relates to bioinformatics, in particular to a method and device for predicting disease susceptibility risk. Background technique [0002] Some chromosomal loci related to the occurrence of diseases corresponding to genetic constitutions that are unfavorable to health are called disease susceptibility loci, and the so-called disease susceptibility refers to the tendency to suffer from a certain type of disease determined by genetics , People with disease susceptibility must have specific genetic characteristics, simply speaking, they have a susceptibility genotype for a certain disease. So far, in the process of medical statistics research in the past ten years, a large number of chromosomal loci have been found to be closely related to the susceptibility of tumors, cardiovascular and cerebrovascular diseases, chronic diseases and other diseases, and have been repeatedly confirmed by independent studies. For a specific disease, the suscep...

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Application Information

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IPC IPC(8): G06F19/10G06F19/24
Inventor 曹鑫恺王立山臧卫东宋伟
Owner 上海尔云信息科技有限公司
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