Patents
Literature
2 results about "Genotype frequency" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Genetic variation in populations can be analyzed and quantified by the frequency of alleles. Two fundamental calculations are central to population genetics: allele frequencies and genotype frequencies. Genotype frequency in a population is the number of individuals with a given genotype divided by the total number of individuals in the population. In population genetics, the genotype frequency is the frequency or proportion (i.e., 0 < f < 1) of genotypes in a population.
A method for systematic screening of genetic lethal intervals at the whole genome level of bivalves
PendingCN122266453AEfficient identificationConvenient farming managementMicrobiological testing/measurementBiostatisticsGeneticsZoology
The application provides a method for screening genetic lethal interval on the whole genome level of shellfish, and belongs to the technical field of shellfish breeding. The method obtains the genotype information of shellfish, locates ROH on the whole genome level, constructs the theoretical distribution of ROH, evaluates the actual distribution of ROH, defines the genetic lethal interval, and determines the genotype of the low survival rate individual by evaluating the genotype frequency and allele frequency distribution characteristics of the sites in the genetic lethal interval. The application can screen the genetic lethal interval on the whole genome level of shellfish, solves the problem that the survival and death of shellfish individuals cannot be converted into phenotype information suitable for traditional genetic analysis, and reveals the distribution characteristics and action mode of the genetic lethal interval on the whole genome level, thereby providing a theoretical basis for designing a shellfish breeding scheme, and providing a reliable standard for screening high-quality parent populations and high-quality breeding populations and improving breeding efficiency.
Owner:OCEAN UNIV OF CHINA
Individual Identification Methods and Systems Based on Whole-Genome Single Nucleotide Polymorphism Data
ActiveCN121459920BSolve key technical problemsget rid of dependenceProteomicsGenomicsGenotyping error rateNucleotide
This invention discloses an individual identification method and system based on whole-genome single nucleotide polymorphism (SNP) data, belonging to the field of forensic genetics technology. The specific steps are as follows: obtaining the intersection SNP sites of the sample pairs to be identified, constructing a linkage-equilibrium SNP site set; evaluating the individual identification ability of the linkage-equilibrium SNP site set based on a power evaluation index, generating an optimal SNP site set; under the set mutual exclusion hypothesis, calculating the probability value of each optimal SNP site based on the population genotype frequency and the prior genotyping error rate, and calculating the total likelihood ratio based on the probability values of each optimal SNP site; selecting a supporting hypothesis or hypothesis based on the relationship between the total likelihood ratio and a preset threshold. This invention, by introducing a semi-continuous likelihood ratio calculation model that integrates the genotyping error rate, can scientifically handle and explain the unavoidable genotyping errors in whole-genome sequencing data.
Owner:SICHUAN UNIV