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Mass calibration material ionizing and introducing device

A technology for introducing devices and calibrators, applied in the field of mass analysis, can solve problems such as mutual interference of ion sources and contamination of mass spectrometers, and achieve the effects of reducing matrix effects, avoiding mutual interference and improving transmission efficiency

Inactive Publication Date: 2015-11-25
SHIMADZU RES LAB SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In view of the above-mentioned shortcomings of the prior art, the object of the present invention is to provide a mass calibrator ionization and introduction device to solve the pollution of the mass calibrator in the above-mentioned mass spectrometer to the mass spectrometer post-stage, and the matrix for analyte detection effects, and the problem of mutual interference between ion sources

Method used

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  • Mass calibration material ionizing and introducing device
  • Mass calibration material ionizing and introducing device
  • Mass calibration material ionizing and introducing device

Examples

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Embodiment 1

[0063] see figure 1 , the present invention provides a mass calibrator ionization and introduction device, comprising: at least one first ion source 1 for mass calibrator ionization, at least one second ion source 2 for analyte ionization, a first The preset chamber 3 of the ion source, at least one ion guiding area 51, the vacuum interface device 4 for connecting the ion source and the ion guiding area, and a mass detection analysis area 52, the ion guiding area 51 is used to guide Lead the mass calibrator ions and analyte ions into the mass detection analysis area 52 connected to the ion guide area 51, and the ion movement can refer to the direction of the arrow shown in the figure; wherein, the first ion source 1 is below Atmospheric pressure environment, the second ion source 2 is in an atmospheric pressure environment.

[0064] On the one hand, the first ion source 1 in a subatmospheric environment includes: electrospray ion source, glow discharge ion source, dielectric ...

Embodiment 2

[0072] Such as figure 2 As shown, the vacuum interface device can have various forms, and the vacuum interface device 4a can be a sampling cone, a round hole, a straight capillary or a curved capillary, for example, as shown in the figure, since the entrance of the ion guiding region 51a is Horizontal straight capillary, so the vacuum interface device 4a of the preset chamber 3a in the vertical direction is a curved capillary, and similar to the angle maintained between the ion sources in Example 1, in this embodiment, the curved capillary The outlet section, that is, the angle between the centerline of the bent section and the centerline of the straight capillary is between 0 and 90 degrees, which can not only be aligned with the entrance of the ion guiding region 51a, but also satisfy the analyte and quality requirements. Calibrators do not affect each other's requirements for efficiency; in other embodiments, the second ion source 2a may also use a curved capillary as a vacu...

Embodiment 3

[0076] Such as Figure 4 As shown, the main difference from the above embodiment is that in this embodiment, the preset chamber 3b includes an ion guide device 33b leading to the ion guide region 51b, if the preset chamber The chamber 3b is provided with the first ion source 1b, and the mass calibrator ions generated by the ionization of the mass calibrator enter into the ion guide area 51b through the ion guide device.

[0077] Preferably, the ion guide device 33b includes: one or a combination of an ion funnel, a multipole ion guide device, a Q-array guide and a traveling wave guide device.

[0078] The ion source under the low-pressure environment is used together with the ion guide device 51b to improve the ion transmission efficiency of the mass calibrator, reduce the usage of the mass calibrator and reduce the pollution to the rear stage of the mass spectrometer.

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Abstract

A mass calibrator ionization and introduction device for a mass spectrometer, comprising at least a first ion source for the mass calibrator ionization (1); at least a second ion source for the ionization analysis (2); independent vacuum interface devices (4) corresponding to respective ion sources; and at least an ion guiding area (51), for guiding the mass calibrator ions and the analyte ions into a quality detection analysis area (52) connected to the ion guiding area (51); wherein the first ion source (1) is in a subatmospheric environment, and the second ion source (2) is in an atmospheric environment. A low pressure environment can more effectively enhance the ionization efficiency and the ion transmission efficiency compared with an atmospheric pressure environment; ensure the mass spectrum signal strength of the mass calibrator and reduce its amount in order to reduce the contamination caused by the mass calibrator to the subsequent stage of the mass spectrum; the respective independent ion sources and vacuum interface devices of mass calibrator and the analyte also avoid the interference caused by the mass calibrator to the analyte and the contamination of the analyte vacuum interface device.

Description

technical field [0001] The invention relates to the technical field of mass analysis, in particular to a mass calibration ionization and introduction device. Background technique [0002] Generally, when people calibrate mass spectrometers, they use external standard method or internal standard method to introduce mass calibrator. In the external standard method, the analyte and the mass calibrator are introduced into the mass spectrometer at different times. In the internal standard method, the analyte and mass calibrator are mixed into one solution and simultaneously introduced into the mass spectrometer. The advantage of the internal standard method over the external standard method is that it can eliminate fluctuations caused by the instrument running at different times. However, the disadvantage of the internal standard method is that the analyte and mass calibrator must be mixed together before being introduced into the mass spectrometer. In this way, during the ion...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/06H01J49/10
CPCH01J49/04
Inventor 王睿张小强沈嘉祺金峤孙文剑
Owner SHIMADZU RES LAB SHANGHAI
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