A kind of dry suspension of montmorillonite pellets and preparation method thereof

A technology of montmorillonite pellets and dry suspension, applied in the field of medicine, can solve the problems of earthy smell, inability to guarantee product uniformity, large effective dose and the like

Active Publication Date: 2017-06-20
HENAN LIFE PHARMA CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the montmorillonite preparations on the market mainly include powders, granules, suspensions and dispersible tablets. These dosage forms have some shortcomings: powders and granules have a gritty and earthy smell when they are mixed with water and taken evenly, which is not easy for patients to accept. Suspensions also have the problem of poor taste; dispersible tablets can be swallowed directly, but the effective dose of this product is relatively large, so the specifications of commercially available dispersible tablets are 1g / tablet, which is difficult to swallow, especially in infants and young children and adolescents when taking
[0004] The document "Azithromycin Taste-Masked Pellets Dry Suspension" reports that Azithromycin is made into pellets, and then adding a suspending agent to make taste-masked pellets dry suspension, but in production practice, due to the prepared pellets and necessary Excipients, such as suspending agents, flavoring agents and essences, have different shapes and particle sizes, so the uniformity of the product cannot be guaranteed in the mixing and filling process
[0005] Through comparison, it is found that the existing montmorillonite preparations generally have a series of problems such as poor taste and inconvenient taking.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of dry suspension of montmorillonite pellets and preparation method thereof
  • A kind of dry suspension of montmorillonite pellets and preparation method thereof
  • A kind of dry suspension of montmorillonite pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] The composition of montmorillonite pellets (500g) is:

[0150] name effect Proportion quality Montmorillonite powder Main drug 80 400g Povidone K30 Adhesive 8 40g Polyacrylic resin IV film coating 12 60g

[0151] The composition of auxiliary material pellets (500g) is:

[0152]

[0153] Montmorillonite pellets: Take the prescribed amount of binder, dissolve it into an appropriate amount of wetting agent (absolute alcohol); add it to the prescribed amount of montmorillonite, and make pellets in the extrusion spheronizer, the particle size is It is 0.1-0.8mm.

[0154] Coating film coating: get the film coating powder of recipe quantity and dissolve in the appropriate wetting agent (85% ethanol), spray evenly on the surface of above-mentioned montmorillonite pellets, and dry with hot air, control weight gain 6%-12 %, the particle size is 0.1-0.8mm.

[0155] Preparation of auxiliary material pellets: take the adhesive of ...

Embodiment 2

[0166] The composition of montmorillonite pellets (500g) is:

[0167]

[0168] The composition of auxiliary material pellets (500g) is:

[0169] name effect Proportion quality sucrose flavoring agent 63 235g Sodium carboxymethyl cellulose suspending agent 30 240g pregelatinized starch Adhesive 7 25g

[0170] Montmorillonite pellets: Take the prescribed amount of binder, dissolve it into an appropriate amount of wetting agent (water); add it to the prescribed amount of montmorillonite, and make pellets in an extrusion spheronizer with a particle size of 0.1 —0.8mm.

[0171] Coating film coating: get the film coating powder of recipe quantity and dissolve in the appropriate wetting agent (85% ethanol), spray evenly on the surface of above-mentioned montmorillonite pellets, and dry with hot air, control weight gain 6%-12 %, the particle size is 0.1-0.8mm.

[0172] Preparation of excipient pellets: Take the prescribed amount of ...

Embodiment 3

[0177] The composition of montmorillonite pellets (500g) is:

[0178]

[0179] The components of auxiliary material pellets (500g) are:

[0180] name effect Proportion quality sucrose flavoring agent 56 280g xanthan gum suspending agent 37 185g pregelatinized starch Adhesive 7 35g

[0181] Montmorillonite pellets: Take the prescribed amount of binder, dissolve it into an appropriate amount of wetting agent (absolute alcohol); add it to the prescribed amount of montmorillonite, and make pellets in the extrusion spheronizer, the particle size is It is 0.1-0.8mm.

[0182] Coating film coating: get the film coating powder of recipe quantity and dissolve in the appropriate amount of wetting agent (20% ethanol), spray evenly on the surface of above-mentioned montmorillonite pellets, and dry with hot air, control weight gain 6%-12 %, the particle size is 0.1-0.8mm.

[0183] Preparation of auxiliary material pellets: take the adhesi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention belongs to the field of medicines, and relates to a montmorillonite pellet dry suspension having good mouthfeel and being convenient to take, and a preparation method thereof. The montmorillonite film coat pellet dry suspension is composed of montmorillonite pellets and auxiliary material pellets according to a weight ratio of 1:4-5:1.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a dry suspension of montmorillonite pellets and a preparation method thereof. Background technique [0002] Montmorillonite has a layered structure and non-uniform charge distribution, which can fix and inhibit viruses, bacteria and the toxins produced in the digestive tract; it has the ability to cover the mucosa of the digestive tract, and by combining with mucus glycoproteins, Repair and improve the defense function of the mucosal barrier against attacking factors from two aspects of quality and quantity. It is used for adjuvant treatment of acute and chronic diarrhea and related pain symptoms caused by esophagus, stomach and duodenal diseases in adults and children. [0003] At present, the montmorillonite preparations on the market mainly include powders, granules, suspensions and dispersible tablets. These dosage forms have some shortcomings: powders and granules have a gritty and ea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K33/06A61P1/12A61P1/00A61P29/00
CPCA61K9/10A61K9/5026A61K9/5047A61K33/06A61K47/36A61K47/38
Inventor 杨定乾高佩武郭海波山魏骆爽
Owner HENAN LIFE PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap