Application of pharmaceutical composition to preparation of medicament for treating cerebral thrombus

A technology of composition and cerebral thrombosis, which is applied in the field of pharmaceutical composition and preparation of drugs for the treatment of cerebral thrombosis, which can solve the problems of insignificant function and complicated preparation of raw materials, and achieve the effect of stable drug effect, good curative effect and fast onset of action

Inactive Publication Date: 2016-01-13
GUANGDONG JUZHICHENG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The raw materials for the preparation of the pharmaceutical composition are relatively complicated. Although it has the functions of promoting blood circulation, removing blood stasis, anti-inflammatory and analgesic functions, its functions in reducing blood sugar, blood lipids and blood pressure, and preventing cerebral thrombosis are not significant.

Method used

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  • Application of pharmaceutical composition to preparation of medicament for treating cerebral thrombus
  • Application of pharmaceutical composition to preparation of medicament for treating cerebral thrombus
  • Application of pharmaceutical composition to preparation of medicament for treating cerebral thrombus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The pharmaceutical composition of Example 1 of the present invention is mainly prepared from the following raw materials in parts by weight:

[0031] 22 parts of Caulis Spatholobus, 24 parts of Chuanxiong, 10 parts of peach kernel, 16 parts of myrrh, 14 parts of veratrum, 12 parts of notopterygium, 16 parts of dandelion, 10 parts of forsythia, 12 parts of calendula chrysanthemum, 8 parts of Moringa leaf, Rehmannia glutinosa Huang 8 parts and licorice 4 parts.

[0032] The preparation method is as follows:

[0033] S1: Take Mildew Spatholobus, wash away impurities, dry and crush, pass through an 80-mesh sieve, add 8 times the total weight of Mildew Spatholobus Spatholobus with a volume fraction of 60% ethanol, and then add 0.8% of the total amount of Mildew Mildew Spatholobus. The cellulase was leached at 38°C for 1 hour, then refluxed at 85°C for 1 hour, filtered and kept the filter residue of Caulis Spatholobus, and the filtrate was concentrated under reduced pressure...

Embodiment 2

[0040] The pharmaceutical composition of Example 2 of the present invention is mainly prepared from the following raw materials in parts by weight:

[0041] 30 parts of Caulis Spatholobus, 30 parts of Chuanxiong, 30 parts of peach kernel, 20 parts of myrrh, 22 parts of veratrum, 22 parts of notopterygium, 24 parts of dandelion, 16 parts of forsythia, 18 parts of calendula chrysanthemum, 18 parts of Moringa leaf, Rehmannia glutinosa Huang 16 parts and licorice 12 parts.

[0042] The preparation method is the same as in Example 1.

Embodiment 3

[0044] The pharmaceutical composition of Example 3 of the present invention is mainly prepared from the following raw materials in parts by weight:

[0045] 26 parts of Caulis Spatholobus, 26 parts of Rhizoma Chuanxiong, 24 parts of Peach Kernel, 18 parts of Myrrh, 18 parts of Veratrum, 16 parts of Notopterygium, 18 parts of Dandelion, 14 parts of Forsythia, 14 parts of Calendula, 16 parts of Moringa leaves, Rehmannia glutinosa Huang 12 parts and licorice 8 parts.

[0046] The preparation method is the same as in Example 1.

[0047] Pharmacodynamic study of the pharmaceutical composition of the present invention:

[0048] Test one: the clinical trial of pharmaceutical composition of the present invention

[0049] (1) Cases and diagnostic criteria

[0050] 1. Diagnostic criteria

[0051] Refer to the diagnostic criteria of the Chinese Medical Association for cerebral thrombosis and cerebral embolism:

[0052] 1) Often occurs in a quiet state;

[0053] 2) Most of them ...

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Abstract

The invention belongs to the field of a traditional Chinese medicine, and relates to an application of a pharmaceutical composition to preparation of a medicament for treating cerebral thrombus. The pharmaceutical composition is mainly prepared by the following raw materials in parts by weight: 22-30 parts of spatholobus stem, 24-30 parts of Szechuan lovage rhizome, 10-30 parts of peach kernel, 16-20 parts of myrrh, 14-22 parts of veratrum root, 12-22 parts of notopterygium root, 16-24 parts of dandelion, 10-16 parts of forsythia fruit, 12-18 parts of pot marigold flower and root, 8-18 parts of horseradish tree leaf, 8-16 parts of cooked rehmannia root and 4-12 parts of liquorice. The pharmaceutical composition has blood quickening and stasis dispelling, qi moving and pain relieving, qi reinforcing and blood nourishing efficacies and the like, and simultaneously the pharmaceutical composition has turbidity transforming, lipid lowering, blood sugar reducing and blood pressure reducing efficacies; the pharmaceutical composition is used for preventing and treating cerebral thrombus, and the effects are substantial.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of a pharmaceutical composition in the preparation of medicines for treating cerebral thrombosis. Background technique [0002] Cerebral thrombosis is one of the three common acute cerebrovascular diseases. The basic cause is the thickening of blood vessels, stenosis and occlusion of the lumen or the formation of thrombus on the basis of stenosis due to atherosclerosis and other autologous diseases, resulting in reduced blood flow or blood supply in the brain. Interrupted, cerebral ischemia and hypoxia lead to softening necrosis and focal neurological symptoms. Common sites of cerebral thrombosis are the internal carotid artery, middle cerebral artery, vertebral artery, and basilar artery, resulting in damage to the sites supplied by these arteries due to ischemia and hypoxia. The main clinical manifestations are sudden numbness ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P7/02A61P25/00
Inventor 邓凤桂
Owner GUANGDONG JUZHICHENG TECH
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