Artemisia sphaerocephala extract, preparation method of extract and application in aspect of blood sugar reduction

A technique for Artemisia argyi and its extract, applied in the field of Artemisia argyi extract and its preparation, can solve the problems of no report of α-glucosidase inhibitor, high requirements on process conditions, limited seed resources, etc., and achieves a favorable ecological environment The effect of repairing, simple process and high nutritional value

Active Publication Date: 2016-01-20
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the secondary metabolites in the body have not been reported on α-glucosidase inhibitors.
Patent 200510002228 applies for the method of preparing Artemisia polysaccharides from Artemisia annua seeds, but the seed resources are very limited, and the patented method uses CO 2 Supercritical extraction requires high process conditions, high production costs, and is difficult to industrialize

Method used

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  • Artemisia sphaerocephala extract, preparation method of extract and application in aspect of blood sugar reduction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The preparation method of Artemisia baicalensis extract of the present invention is as follows:

[0013] The fresh leaves are collected from the mature stage (August) of Artemisia baicalensis in Alashan area, dried in the shade, crushed, and passed through a 100-mesh sieve to obtain fine powder. The leaf fine powder is extracted with 20 times absolute ethanol solution, ultrasonically extracted for 60 minutes, repeated extraction 3 times, and concentrated under reduced pressure at a temperature lower than 40°C. Dry it in a dark, low-temperature and well-ventilated place to prepare the extract. The extract was a black solid, 4.76g. Dissolve Artemisia alba extract with 10 times the volume of water (30-40°C, 50mL), extract 3 times with petroleum ether (100mL) that is 2 times the volume of the aqueous solution, and reduce the upper layer of petroleum ether at a temperature lower than 40°C. Concentrate under pressure and air-dry to obtain the petroleum ether fraction. If s...

Embodiment 2

[0015] The preparation method of Artemisia baicalensis extract of the present invention is as follows:

[0016] Collect the fresh leaves of Artemisia baicalensis at the mature stage, dry them in the shade and pulverize them, and pass through a 100-mesh sieve to obtain fine powder. The leaf fine powder was extracted with 20 times absolute ethanol solution, ultrasonically extracted for 30 minutes, repeated extraction twice, and concentrated under reduced pressure. Dry it in a dark, low-temperature and well-ventilated place to prepare the extract. Dissolve Artemisia alba extract in 3 times the volume of water, extract once with petroleum ether of the same volume as the aqueous solution, concentrate and air-dry the petroleum ether part under reduced pressure to obtain the petroleum ether part; extract with ethyl acetate of the same volume as the aqueous solution The remaining aqueous solution was taken once, and the ethyl acetate fraction was concentrated under reduced pressure a...

Embodiment 3

[0018] The preparation method of Artemisia baicalensis extract of the present invention is as follows:

[0019] Collect the fresh leaves of Artemisia baicalensis at the mature stage, dry them in the shade and pulverize them, and pass through a 100-mesh sieve to obtain fine powder. The leaf fine powder was extracted with 5 times absolute ethanol solution, ultrasonically extracted for 10 minutes, repeated extraction 4 times, and concentrated under reduced pressure. Dry it in a dark, low-temperature and well-ventilated place to prepare the extract. Dissolve Artemisia alba extract in 2 times the volume of water, first extract 3 times with petroleum ether with 2 times the volume of the aqueous solution, combine the petroleum ether part, concentrate under reduced pressure and air-dry to obtain the petroleum ether part; use 2 times the volume of the aqueous solution The remaining aqueous solution was extracted three times with ethyl acetate, the ethyl acetate fractions were combined...

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Abstract

The invention provides a method for extracting and preparing active ingredients of artemisia sphaerocephala leaves. The invention also provides an application of the prepared artemisia sphaerocephala extract in aspects of reducing glucosidase activity and treating diabetes. The artemisia sphaerocephala extract serves as a plant source medicine, the glucosidase activity is effectively reduced, a few side effects are caused, a novel treatment means is provided for diabetes treatment, and the extract has an important significance for scientifically, reasonably and sustainably developing and utilizing artemisia sphaerocephala resources. The preparation process is simple, environmental-friendly, low in development cost and obvious in economic benefits.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to an Artemisia annua extract, a preparation method thereof and an application in treating diabetes. Background technique [0002] Diabetes mellitus is a metabolic disease associated with abnormal insulin production and action and characterized by hyperglycemia, for which there is no cure. Recent studies have found that in the onset of diabetes, postprandial hyperglycemia often occurs first, and then develops into diabetes, that is, the former is an early sign of the latter. For diabetic patients, especially type Ⅱ patients, postprandial hyperglycemia is far more harmful to the body than fasting hyperglycemia. Postprandial hyperglycemia stimulates the pancreas to secrete a large amount of insulin, which can cause various metabolic abnormalities and vascular lesions. Functionality is further compromised. Therefore, reducing postprandial blood sugar is one of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61P3/10A61K127/00
Inventor 刘权傅华南志标
Owner LANZHOU UNIVERSITY
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