Traditional Chinese medicine combination extract and application thereof in preparation of medicines for treating cervical carcinoma

Abstract

The invention discloses a traditional Chinese medicine combination extract and application thereof in preparation of medicines for treating cervical carcinoma. The traditional Chinese medicine combination extract is prepared from lysimachia candida, cortex dictamni, arcangelisia loureiri and red sage root through the following steps: cleaning all raw materials, airing, then crushing and mixing, collecting extracted volatile oil by adopting a supercritical carbon dioxide extraction technology, carrying out warm-infusion extraction with ethanol, collecting an extracting solution, adding water for reflux extraction, and separating and purifying the extracting solution with a liquid chromatograph, thereby obtaining the target traditional Chinese medicine composition. The traditional Chinese medicine combination extract serves as an active ingredient to be applied to preparation of medicines for treating cervical carcinoma in a pharmaceutical composition accepting additives in pharmaceutics. All components in the medicine disclosed by the invention are synergistic and have a good therapeutic effect on cervical carcinoma. The invention provides a new medicine for patients with cervical carcinoma, and the medicine is small in toxic or side effect and free of adverse reaction.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine combination extract and its application in the preparation of medicines for treating cervical cancer. Background technique [0002] Cervical cancer refers to malignant tumors that occur at the junction of squamous epithelial cells of the cervicovaginal or transition zone and columnar epithelial cells of the endocervical endometrium. Cervical cancer is the most common malignant tumor of the cervix in female reproductive system tumors. The clinical manifestations of menstruation or excessive leucorrhea, irregular vaginal bleeding, waist and abdomen pain, anemia, emaciation and other systemic debilitating symptoms. In recent years, the incidence of cervical cancer has continued to rise, and the incidence of cervical cancer is gradually becoming younger. The long-term clinical point of view is that the sensitivity of cervical canc...

AI Technical Summary

Problems solved by technology

The long-term clinical point of view is that the sensitivity of cervical cancer chemotherapy is poor, and the effective rate is lower than 15%. At present, chemotherapy drugs for cervical cancer can be injected intravenously or locally with 5-fluorouracil, doxorubicin, etc., but doxorubicin Toxic reaction is relatively serious, and carcinogenic effect was found in animal experiments, and it also has potential carcinogenic and mutagenic effects in the human body, which has a significant impact on reproductive function

Moreover, the current surgical plan to remove cancerous tissue and radiotherapy and chemotherapy not only has a low cure rate, but also causes excessive physical harm to women.

Traditional Chinese medicine treatment has the advantages of less side effects, good anti-relapse rate effect, can stabilize the disease, and does not spread. Some traditional Chinese medicine formulas have been clinically practiced, and the therapeutic effect is not very satisfactory. Therefore, it is urgent to find a traditional Chinese medicine treatment drug for cervical cancer with low toxicity and significant effect.