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Nonlinear saccharide conjugates

A technology of glycoconjugates and non-linear chains, which can be used in drug combinations, medical preparations of non-active ingredients, carrier-bound antigen/hapten components, etc., and can solve problems such as adverse interactions and difficulties in increasing immune programs

Inactive Publication Date: 2016-02-03
GLAXOSMITHKLINE BIOLOGICALS SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Second, adding new vaccines to an already crowded immunization schedule will become increasingly difficult because of possible adverse interactions, but also simply because of the number of separate injections required

Method used

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  • Nonlinear saccharide conjugates
  • Nonlinear saccharide conjugates
  • Nonlinear saccharide conjugates

Examples

Experimental program
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Embodiment Construction

[0307] overview

[0308] Meningococcal disease is of outstanding public health concern because of its extremely rapid onset and progression; the disease can be fatal in the order of hours. Surface polysaccharides have long been key antigens for vaccines against the major pathogenic meningococcal serogroups A, C, W-135 and Y [Bardotti, A. et al. Vaccine , 2008, 26(18), 2284-2296; Broker, M. et al. Vaccine , 2009, 27(41), 5574-5580; Fusco, P.C. et al. Clin Vaccine Immunol .2007, 14(5), 577-584.]. Conjugation of polysaccharides to carrier proteins has conferred important public health benefits, improved their immunogenicity, and allowed the induction of T cell-dependent (TD) responses [Pollard, A.J. et al. Nat. Rev. Immunol .2009, 9(3), 213-220; Ada, G. et al. Clin. Microbiol. Infect .2003, 9(2), 79-85]. Thus, saccharides from meningococcal serogroups provide exemplary saccharides for use in illustrating the conjugates disclosed herein. To study non-linear conjugates a...

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Abstract

This specification is directed to nonlinear saccharide conjugates that comprise polysaccharides that are linked to at least two peptides that comprise T-cell epitopes and have no conformational B-cell epitopes where one of the peptides is linked to an internal saccharide so that the conjugates have a branched (i.e., nonlinear) structure. The specification also provides methods of manufacturing these conjugates, methods of formulating these conjugates in compositions for use as vaccines and methods of using the compositions to induce an immune response to the capsular saccharide. The specification also provides a new polyepitope carrier peptidecomprising the PV1 epitope from polio virus. The new polyepitope carrier peptidecan be used in both linear saccharide conjugates as well as the nonlinear saccharide conjugates.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Application No. 61 / 709,093, filed October 2, 2012. The entire content of the above application is incorporated herein by reference for all purposes. technical field [0003] The present invention relates to immunization using non-linear glycoconjugates comprising polysaccharides or oligosaccharides linked to at least two carrier peptides comprising T-cell epitopes and not having any A conformational B cell epitope wherein one of the carrier peptides is linked to an internal sugar. Of particular interest is the use of such compositions as vaccines against bacterial and fungal infections and diseases. The present invention also relates to immunization using a non-linear glycoconjugate comprising a polysaccharide or oligosaccharide linked to at least one carrier peptide comprising at least two PV1 T cell epitopes and Does not possess any conformational B-cell epitopes. Background techni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K39/095A61P31/04A61P37/04
CPCA61K39/095A61K2039/55505A61K2039/6031A61K2039/6037A61K2039/627A61K47/646A61P31/04A61P31/06A61P31/10A61P33/04A61P37/04Y02A50/30A61K39/385
Inventor F.伯蒂G.布罗乔尼P.科斯坦蒂诺G.德尔朱迪斯M.罗马诺
Owner GLAXOSMITHKLINE BIOLOGICALS SA
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