Superfine wall-breaking pulverization method for fructus swietenia macrophylla

A technology of ultra-fine wall-breaking pulverization and Tianguo powder, which is applied in the field of medicine, can solve the problems of low powder yield, long pulverization time, and high loss rate of flavonoids to Tianguo, and achieves the effects of high powder yield and short processing time.

Inactive Publication Date: 2016-02-24
SUZHOU PULUODA BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing ultrafine crushing method of Xiangtianguo has problems such as long crushing time, low powder extraction rate and high loss rate of Xiangtianguo flavonoids

Method used

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  • Superfine wall-breaking pulverization method for fructus swietenia macrophylla
  • Superfine wall-breaking pulverization method for fructus swietenia macrophylla
  • Superfine wall-breaking pulverization method for fructus swietenia macrophylla

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Grind 3kg of Xiangtianguo and pass through a 60-80 mesh sieve to obtain Xiangtianguo powder; mix 8g of hydroxypropyl-β-cyclodextrin and 2g of medium-chain triglycerides evenly to obtain hydroxypropyl-β-cyclodextrin -Medium chain triglyceride mixed powder; mix Xiangtian fruit powder with hydroxypropyl-β-cyclodextrin-medium chain triglyceride mixed powder evenly, and use SWFJ ultrafine pulverizer to pulverize for 1 hour, and measure the average particle size of the obtained powder , powder extraction rate, retention rate and dissolution rate of the flavonoids of the fruit, the results are shown in Table 1.

[0017] The related data of Xiangtianguo superfine powder of table 1 embodiment 1

[0018]

Embodiment 2

[0020] Crush 3kg of Xiangtianguo and pass through a 60-80 mesh sieve to obtain Xiangtianguo powder; mix 12g of hydroxypropyl-β-cyclodextrin and 3g of medium-chain triglycerides evenly to obtain hydroxypropyl-β-cyclodextrin -Medium chain triglyceride mixed powder; mix Xiangtian fruit powder with hydroxypropyl-β-cyclodextrin-medium chain triglyceride mixed powder evenly, and use SWFJ ultrafine pulverizer to pulverize for 1 hour, and measure the average particle size of the obtained powder , powder extraction rate, retention rate and dissolution rate of the flavonoids of the fruit, the results are shown in Table 2.

[0021] The sky fruit superfine powder related data of table 2 embodiment 2

[0022]

Embodiment 3

[0024] Grind 3kg of Xiangtianguo and pass through a 60-80 mesh sieve to obtain Xiangtianguo powder; mix 9.6g of hydroxypropyl-β-cyclodextrin and 2.4g of medium-chain triglycerides evenly to obtain hydroxypropyl-β-cyclodextrin Dextrin-medium-chain triglyceride mixed powder; mix Xiangtianguo powder with hydroxypropyl-β-cyclodextrin-medium-chain triglyceride mixed powder evenly, and use SWFJ superfine pulverizer to pulverize for 1 hour, and the obtained powder measures the average See Table 3 for the results of particle size, powder extraction rate, retention rate and dissolution rate of the flavonoids of the fruit.

[0025] The related data of Xiangtianguo superfine powder of table 3 embodiment 3

[0026]

[0027]

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Abstract

The invention provides a superfine wall-breaking pulverization method for fructus swietenia macrophylla and belongs to the field of traditional Chinese medicine. The superfine wall-breaking pulverization method for the fructus swietenia macrophylla is characterized by including the steps of (1) pulverizing the fructus swietenia macrophylla and sieving the pulverized fructus swietenia macrophylla by a 60-80-mesh sieve so as to obtain fructus swietenia macrophylla powder; (2) uniformly mixing hydroxypropyl-beta-cyclodextrin with medium chain triglyceride in a preferred mass ratio of 8:2 so as to obtain hydroxypropyl-beta-cyclodextrin-medium chain triglyceride mixed powder; (3) uniformly mixing the fructus swietenia macrophylla powder with the hydroxypropyl-beta-cyclodextrin-medium chain triglyceride mixed powder in a preferred mass ratio of 300-200:1. Compared with a conventional superfine wall-breaking pulverization method, the superfine wall-breaking pulverization method for the fructus swietenia macrophylla has the advantages of short preparation time, high powder yield, high fructus swietenia macrophylla flavone retention rate and dissolution rate, small average grain size of the powder and the like.

Description

technical field [0001] The invention relates to a method for ultrafine wall-breaking and crushing of Tianguo, which belongs to the technical field of medicine. Background technique [0002] Xiangtianguo is the fruit of the Meliaceae plant Xiangtianguo tree. It is known as the "Queen of Plants". It has antipyretic, astringent, and strong effects. It is mainly used for diabetes and high blood pressure. It is often used in powder form. [0003] After the Tianguo is ultrafinely pulverized, due to the increase in the specific surface area of ​​the particle size, the dissolution rate of active ingredients such as Tianguo flavonoids can be greatly increased, thereby improving the efficacy of the medicine. The existing ultrafine wall-broken crushing method of Xiangtianguo has problems such as long crushing time, low powder yield and high loss rate of Xiangtianguo flavonoids. Contents of the invention [0004] The purpose of the present invention is to provide a method for ultrafi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/58A61K47/40A61K47/14A61P9/12A61P3/10
CPCA61K36/58A61K47/14A61K47/40A61K2236/15
Inventor 罗瑞雪张振海
Owner SUZHOU PULUODA BIOLOGICAL SCI & TECH
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