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New use of pharmaceutical composition

A composition and medicine technology, applied in the field of public traditional Chinese medicine compound Sophora flavescens injection, can solve the problems of residual cancer, inconspicuous early symptoms, the existence of tumor thrombus in blood vessels, and the like

Inactive Publication Date: 2016-03-16
北京振东生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the early symptoms of rectal cancer are not obvious, many patients are already in the middle and advanced stage when they are diagnosed. Surgical treatment can remove the cancer, but there are still residual cancer, regional lymph node metastasis, or tumor thrombus in blood vessels. Has no effect on systemic treatment and improvement of the body's defense response

Method used

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  • New use of pharmaceutical composition
  • New use of pharmaceutical composition
  • New use of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] The raw material medicine of compound Kushen injection consists of:

[0106] 1400 parts of Sophora flavescens, 600 parts of Bai Tu Ling.

[0107] Grind the Erwei crude drug into coarse powder, mix it evenly, put it in a percolation tank, add 1% acetic acid equivalent to 5 times of the drug amount, and impregnate for 48 hours, then carry out percolation, collect the filtrate, and concentrate it under reduced pressure at 75°C to Appropriate amount, store in another container, add 5 times the amount of water for injection to the dregs, decoct twice, 1 hour each time, combine the filtrate, concentrate to an appropriate amount, let cool, centrifuge, combine the supernatant with the acid concentrate, and adjust to 1000 volume Parts, add ethanol to precipitate 2 times, first make the alcohol content of the solution reach 65%, let it stand overnight, centrifuge, recover the ethanol from the supernatant under reduced pressure, concentrate to 500 parts by volume, then add ethanol...

Embodiment 2

[0109] The raw material medicine of compound Kushen injection consists of:

[0110] 1400 parts of Sophora flavescens, 600 parts of Bai Tu Ling.

[0111] According to the percolation method (Appendix 10 of the Chinese Pharmacopoeia 2010 edition) under the liquid extract and the extract item of Erwei crude drug, use 1% acetic acid solution as solvent, after soaking for 24 to 30 hours, percolate for 24 hours, collect Percolate: decoct the medicinal dregs with water twice, each time for 1 hour, after the filtrate is combined with the above percolate, concentrate to an appropriate amount, add ethanol to make the alcohol content reach 60%, let stand, filter, recover ethanol, and Concentrate the medicinal solution under reduced pressure, add ethanol to make the alcohol content 80%, let stand, filter, recover ethanol, and concentrate the medicinal solution under reduced pressure, add ethanol to make the alcohol content 90%, let stand, recover and remove Use 20% sodium hydroxide solut...

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PUM

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Abstract

The invention provides new medical use of compound sophora flavescens injection, and the use refers to application in preparation of drugs treating colorectal cancer, in particular to the application in drugs treating advanced colorectal cancer. The compound sophora flavescens injection provided by the invention has precise prescription and remarkable curative effect, is especially suitable for treatment of advanced rectal cancer symptoms, can be used for single treatment, and also can be used in combination with surgery, radiotherapy or chemotherapy. Clinical test shows that the Chinese medicinal composition provided by the invention has an effective rate up to 96.8% and a cure rate up to 61.3%.

Description

technical field [0001] The invention discloses a new application of traditional Chinese medicine compound Sophora flavescens injection (trade name: Yanshu). The new application is in the preparation of drugs for the treatment of colorectal cancer, especially advanced colorectal cancer. Background technique [0002] Colon cancer and rectal cancer are collectively referred to as colorectal cancer, the so-called colorectal cancer, which refers to the malignant lesion of the large intestine mucosal epithelium under the action of various carcinogenic factors such as environment or heredity, that is, the malignant tumor originating from the large intestine mucosal epithelium, is the most It is one of the common malignant tumors of the digestive tract, ranking third in the global malignant tumors, and with the improvement of living standards and changes in dietary structure, the incidence of colorectal cancer continues to rise. Surgical treatment is the first choice for the treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/08A61P35/00
CPCA61K36/896A61K9/0019A61K9/08A61K36/489A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 王瑞峰海丽娜王金华潘晓娟雷娜沈燕孟杨秦文杰李明花李安平
Owner 北京振东生物科技有限公司
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