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Early diagnostic markers for acute myocardial infarction

A kind of acute myocardial infarction, gene technology, applied in the direction of disease diagnosis, biological testing, drug combination, etc., can solve the problem of acute myocardial infarction can not reflect the early diagnosis, to achieve the effect of early diagnosis, reduce mortality, and timely genetic diagnosis

Active Publication Date: 2018-07-17
TIANJIN PEOPLE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The diagnosis of acute myocardial infarction through the detection of white blood cell count and other immune cells cannot reflect the concept of early diagnosis

Method used

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  • Early diagnostic markers for acute myocardial infarction
  • Early diagnostic markers for acute myocardial infarction
  • Early diagnostic markers for acute myocardial infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Screening of genes differentially expressed in patients with acute myocardial infarction and normal people

[0046] 1. Research object:

[0047] Collect 5 cases of healthy people (normal control group) and select 5 cases of outpatients with acute myocardial infarction. No gender limit, no age limit. All patients with AMI met the standards established by the International Society of Cardiology and Associations and WHO Clinical Nomenclature Standardization Joint Task Force in 1979. All patients were excluded from malignant tumors, acute infection, trauma and severe liver and kidney diseases, cerebral embolism, pulmonary embolism, lower extremity venous thrombosis, DIC and acute renal insufficiency and other diseases.

[0048] All research subjects were informed about this study and signed the informed consent.

[0049] 2. Blood collection method

[0050] The subjects drew 2ml of blood from the antecubital vein on an empty stomach in a quiet state in the morn...

Embodiment 2

[0076] Example 2 QPCR experiment verification of genes differentially expressed in patients with acute myocardial infarction and normal people

[0077] 1. Research object:

[0078] Collect 40 cases of healthy people (normal control group) and select 40 cases of outpatients with acute myocardial infarction. No gender limit, no age limit. All patients with AMI met the standards established by the International Society of Cardiology and Associations and WHO Clinical Nomenclature Standardization Joint Task Force in 1979. All patients were excluded from malignant tumors, acute infection, trauma and severe liver and kidney diseases, cerebral embolism, pulmonary embolism, lower extremity venous thrombosis, DIC and acute renal insufficiency and other diseases.

[0079] All research subjects were informed about this study and signed the informed consent.

[0080] 2. Blood collection method

[0081] Step is with embodiment 1.

[0082] 3. Extraction of total RNA in blood

[0083] S...

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Abstract

The invention discloses a DSG3 gene as a molecular marker for early diagnosis of acute myocardial infarction. By utilization of a gene chip and a QPCR method, the situation is discovered that expressions of the DSG3 gene in blood of normal persons and patients with acute myocardial infarction show significant difference, and whether a subject suffers from acute myocardial infarction can be determined through detection of the expression situation of the DSG3 gene in blood. A kit for diagnosis of acute myocardial infarction is developed according to correlation. Diagnosis of acute myocardial infarction is carried out through detection of expression of the DSG3 by utilization of the kit. The diagnostic kit can be used for early diagnosis of diseases, and has wide application prospects in clinic.

Description

technical field [0001] The invention belongs to the field of molecular diagnosis, and relates to a molecular marker for the diagnosis of acute myocardial infarction, in particular to the application of the molecular marker-DSG3 gene in blood in the preparation of products for diagnosing acute myocardial infarction. Background technique [0002] Acute myocardial infarction (AMI) is myocardial necrosis caused by acute and persistent coronary ischemia and hypoxia. Clinically, there are often severe and persistent substernal pains, which cannot be completely relieved by rest and nitrates, accompanied by increased serum myocardial enzyme activity and progressive ECG changes, which may be complicated by arrhythmia, shock or heart failure, often life-threatening. The disease is most common in Europe and the United States, and about 1.5 million people in the United States suffer from myocardial infarction every year. China has shown a clear upward trend in recent years, with at lea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883G01N33/68A61K45/06A61P9/10
CPCA61K45/06C12Q1/6883C12Q2600/158G01N33/68G01N2333/705G01N2800/324
Inventor 曹月娟李荣庆李阳春张涛吴楠张凤萍张建艳郭兆增
Owner TIANJIN PEOPLE HOSPITAL
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