Synsepalum dulcificum leaf extract and application of same in preparation of drugs or health products used for treating diabetes or hyperlipidemia

A technology of miracle fruit leaves and extracts, which is applied in the field of traditional Chinese medicine and natural medicines, can solve the problems that the hypoglycemic effect of miracle fruit leaf extracts has not been reported, and achieve the effects of increasing insulin content, controlling drug quality, and lowering cholesterol

Active Publication Date: 2016-03-30
深圳市神秘果实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report that the extract of miracle fruit leaves has a hypoglycemic effect. Therefore, the use of miracle fruit leaves

Method used

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  • Synsepalum dulcificum leaf extract and application of same in preparation of drugs or health products used for treating diabetes or hyperlipidemia
  • Synsepalum dulcificum leaf extract and application of same in preparation of drugs or health products used for treating diabetes or hyperlipidemia
  • Synsepalum dulcificum leaf extract and application of same in preparation of drugs or health products used for treating diabetes or hyperlipidemia

Examples

Experimental program
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Effect test

Embodiment 1

[0030] The preparation of embodiment 1β-amyl alcohol acetate and lupeol acetate

[0031] S1. Weigh 2Kg of dried miracle fruit leaves and pulverize them, pass through a 60-mesh sieve, then use 5L of 70% ethanol aqueous solution to heat and reflux for extraction. The number of extractions is 2 times, each time for 1 hour, and concentrate the extract to obtain the miracle fruit leaf ethanol Extract;

[0032] S2. Add 2L of water to the ethanol extract of miracle fruit leaves and mix evenly, then add chloroform to extract, extract 3 times, the amount of chloroform each time is 2L, and concentrate under reduced pressure to remove chloroform to obtain a chloroform extract;

[0033] S3. Take 40g of chloroform extract, dissolve it with methanol, then mix the sample with 40g of silica gel (100 mesh), and take another 800g of silica gel (300 mesh) for dry packing, put the sample on the silica gel column, first use a volume ratio of 95 :5 chloroform:methanol mixed solvent system for elut...

Embodiment 2

[0037] The preparation of embodiment 2 miracle fruit leaf extract

[0038] S1. Weigh 2Kg of dried miracle fruit leaves and pulverize them, pass through a 60-mesh sieve, then use 5L of 70% ethanol aqueous solution to heat and reflux for extraction. The number of extractions is 2 times, each time for 1 hour, and concentrate the extract to obtain the miracle fruit leaf ethanol Extract;

[0039] S2. Add 2L of water to the ethanol extract of miracle fruit leaves and mix evenly, then add chloroform to extract, extract 3 times, the amount of chloroform each time is 2L, and concentrate under reduced pressure to remove chloroform to obtain a chloroform extract;

[0040] S3. Take 40g of chloroform extract, dissolve it with methanol, then mix the sample with 40g of silica gel (100 mesh), and take another 800g of silica gel (300 mesh) for dry packing, put the sample on the silica gel column, first use a volume ratio of 95 :5 chloroform:methanol mixed solvent system for elution and remova...

Embodiment 3

[0042] The preparation of embodiment 3 miracle fruit leaf extract

[0043] S1. Weigh 2Kg of dried miracle fruit leaves and pulverize them, pass through a 60-mesh sieve, then use 5L of 70% ethanol aqueous solution to heat and reflux for extraction. The number of extractions is 2 times, each time for 1 hour, and concentrate the extract to obtain the miracle fruit leaf ethanol Extract;

[0044] S2. Add 2L of water to the ethanol extract of miracle fruit leaves and mix evenly, then add chloroform to extract, extract 3 times, the amount of chloroform each time is 2L, and concentrate under reduced pressure to remove chloroform to obtain a chloroform extract;

[0045] S3. Take 40g of chloroform extract, dissolve it with methanol, then mix the sample with 40g of silica gel (100 mesh), and take another 800g of silica gel (300 mesh) for dry packing, put the sample on the silica gel column, first use a volume ratio of 95 :5 chloroform:methanol mixed solvent system for elution and remova...

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Abstract

The invention relates to the technical field of traditional Chinese medicines and crude drugs, specifically to a Synsepalum dulcificum leaf extract and application of the same in preparation of drugs or health products used for treating diabetes or hyperlipidemia. The extract contains an effective component beta-Amyrin acetate and/or another effective component lupeol acetate. The extract exerts good effect on reducing blood sugar and increasing the content of insulin in blood and can be used as a drug or health product for treating diabetes; moreover, the effective components of the extract are definite, which is beneficial for controlling drug quality and medication safety.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine and natural medicine, in particular to a miraculous fruit leaf extract and its application in the preparation of medicines or health care products for treating diabetes or hyperlipidemia. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. Hyperglycemia that exists for a long time in diabetes will lead to various [0003] Various tissues, especially the chronic damage and dysfunction of the eyes, kidneys, heart, blood vessels, and nerves. Therefore, it is of great significance to develop a drug for treating diabetes. [0004] Miracle fruit, whose Latin scientific name is Synsepalum dulcificum Daniell, is a typical tropical evergreen wood, [0005] The origin is in West Africa, Ghana, and Congo. In the 1960s, when Premier Zhou E...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K36/185A61P3/10A61P3/06A23L33/105
CPCA23V2002/00A61K31/56A61K36/185A61K2236/333A61K2236/35A61K2236/55A23V2200/30A23V2200/3262A23V2200/328A61K2300/00
Inventor 王国才禤文生
Owner 深圳市神秘果实业有限公司
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