Application of cardiospermum halicacabum extract in preparation of medicinal preparations for treating diabetes

A technology for pharmaceutical preparations and extracts, which is applied in the application field of extracts of bell peppers in the preparation of pharmaceutical preparations for treating diabetes, can solve problems such as side effects and the like

Inactive Publication Date: 2016-05-04
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

The α-glucosidase inhibitors clinically used to treat diabetes mainly include acarbose, voglibose, miglitol, etc., but these compounds have cer

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  • Application of cardiospermum halicacabum extract in preparation of medicinal preparations for treating diabetes
  • Application of cardiospermum halicacabum extract in preparation of medicinal preparations for treating diabetes
  • Application of cardiospermum halicacabum extract in preparation of medicinal preparations for treating diabetes

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Embodiment Construction

[0014] The present invention will be further described in detail below in conjunction with the embodiments, so that those skilled in the art can implement it with reference to the description.

[0015] It should be noted that the experimental methods described in the following embodiments, unless otherwise specified, are conventional methods, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0016] The structural formula of 3β-erythyl alcohol is:

[0017] 1. Extraction process

[0018] 1. Raw material preparation

[0019] The whole herb of Rhododendron was collected in the suburbs of Nanning, Guangxi. It was identified as the dry whole herb of Rhizoma sapindus by Liao Yuekui, a senior experimenter in the Department of Traditional Chinese Medicine Identification, Guangxi College of Traditional Chinese Medicine. The specimens are stored in the Department of Chemistry of Chinese Medicine, Guangxi University of Traditional C...

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Abstract

The invention discloses an application of a cardiospermum halicacabum extract in the preparation of medicinal preparations for treating diabetes. The cardiospermum halicacabum extract comprises taraxerol and/or 3[beta]-alnusonol. The results of alpha-glucosidase inhibition experiment show that taraxerol and 3[beta]-alnusonol can both inhibit the activity of alpha-glucosidase, the inhibition performance of taraxerol and 3[beta]-alnusonol is highly similar with that of a reference substance (acarbose), and thus the cardiospermum halicacabum extract can be used to treat diabetes.

Description

technical field [0001] The present invention relates to the application of an extract of Bougainvillea chinensis. More specifically, the present invention relates to the application of an extract of Bodiba chinensis in the preparation of pharmaceutical preparations for treating diabetes. Background technique [0002] Cardiospermum halicacabum L. is the dry whole herb of Sapindaceae plant Cardiospermum halicacabum L., also known as false bitter gourd, ghost lantern, and triangular lantern. Mainly distributed in southwestern parts of Guangdong, Guangxi, Fujian, Taiwan, etc., it is mostly used by folks to treat diabetes, pneumonia, jaundice, gonorrhea, rheumatism, bruises, snake bites, etc. When our research group researched the pharmacological effect of Bodiba bellum on lowering blood sugar, it was found that its ethanol extract can significantly reduce the blood sugar level of alloxan-induced diabetic mice and adrenaline-induced diabetic mice, and the ethyl acetate and n-but...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P3/10
CPCA61K31/56
Inventor 霍丽妮韦建华陈睿李培源卢汝梅
Owner GUANGXI UNIV OF CHINESE MEDICINE
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