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Antibacterial anti-inflammatory capsule quality detection method

A quality inspection method, antibacterial and anti-inflammatory technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of product quality inspection, qualitative and quantitative monitoring, etc., and achieve high precision, strong specificity, and accurate content determination. Effect

Inactive Publication Date: 2016-05-25
贵州省科晖制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the original antibacterial and anti-inflammatory tablet standards did not conduct qualitative and quantitative monitoring of the active ingredients of any drug in the formula, and could not effectively test the quality of the product

Method used

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  • Antibacterial anti-inflammatory capsule quality detection method
  • Antibacterial anti-inflammatory capsule quality detection method
  • Antibacterial anti-inflammatory capsule quality detection method

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0039] Experimental Example: Determination of Baicalin Content

[0040] (1) Selection of mobile phase:

[0041] Mobile phase 1: acetonitrile-1% glacial acetic acid (25:75);

[0042] Mobile phase 2: acetonitrile-1% glacial acetic acid (20:80);

[0043] Mobile phase 3: acetonitrile-0.02% phosphoric acid (25:75);

[0044] Mobile phase 4: methanol-water-glacial acetic acid (53:47:1)

[0045] Mobile phase 5: methanol-water-glacial acetic acid (53:47:3)

[0046] Through the analysis of the above comparative test results, the mobile phase 5 has the characteristics of appropriate retention time, good sample separation effect, negative and no interference; at the same time, according to the follow-up test analysis summary, the number of theoretical plates of the sample is between 2000-9000 range, so It is stipulated that the number of theoretical plates of baicalin should not be less than 2000.

[0047] (2) Screening of the preparation method of the test solution:

[0048] In this ...

Embodiment

[0074] A quality detection method for antibacterial and anti-inflammatory capsules, wherein the antibacterial and anti-inflammatory capsules are prepared from honeysuckle, baebu, rhubarb, Folium folium, scutellaria baicalensis, anemarrhena and desmodium, comprising the following steps:

[0075] (1) Chromatographic conditions and system applicability experiment: polar silica gel is used as filler; water, methanol, and glacial acetic acid are used as mobile phase at a volume ratio of 51:45:2, PH=2.5; detection wavelength is 275nm; theoretical plate The number should not be less than 2000 based on the baicalin peak;

[0076] (2) Preparation of reference substance solution: Accurately weigh an appropriate amount of baicalin reference substance, add methanol to make a solution containing 0.04mg per 1ml, and set aside;

[0077] (3) Preparation of the test solution: Take 0.25g of the 70-mesh fine powder of this product, weigh it accurately, add 25ml of ethanol with a mass percentage ...

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Abstract

The invention discloses an antibacterial anti-inflammatory capsule quality detection method. Antibacterial anti-inflammatory capsules are prepared from honeysuckle flowers, radix stemonae, Chinese rhubarb, folium isatidis, radix scutellariae, rhizoma anemarrhenae and a christina loosestrife herb. The antibacterial anti-inflammatory capsule quality detection method comprises the four steps of suitability test on chromatographic conditions and a system, preparation of a reference substance solution, preparation of a test sample solution and determination. In addition, the radix stemonae, the Chinese rhubarb, the radix scutellariae, the rhizoma anemarrhenae and the honeysuckle flowers are subjected to thin-layer identification. The antibacterial anti-inflammatory capsule quality detection method has the advantages of being simple and easy to operate and capable of effectively controlling the product quality.

Description

technical field [0001] The invention belongs to the technical field of quality control of traditional Chinese medicine preparations, and in particular relates to a quality detection method for antibacterial and anti-inflammatory capsules. Background technique [0002] Antibacterial and anti-inflammatory capsules are the modified dosage forms of antibacterial and anti-inflammatory tablets recorded in the seventh volume of drug standards issued by the Ministry (WS3-B-1339-93). Composed of grass and seven herbs, it has the effects of clearing away heat, purging fire, and detoxifying. It can be used for wind-heat and cold, sore throat, and toothache caused by excess fire. Antibacterial and anti-inflammatory capsules have unique therapeutic effects, can partially replace chemical antibiotics, and play a certain role in reducing the abuse of western medicine antibiotics in my country. [0003] Prescription: Honeysuckle clears heat and detoxifies, cools wind and heat; Baibu mois...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 霍昕高玉琼崔伟徐康东陆宽杨迺嘉
Owner 贵州省科晖制药有限公司
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