Crystal form B and preparation method
A technology of crystal form and diffraction peak, applied in the field of medicinal chemistry, can solve the problems of poor stability and incompatibility, and achieve the effects of good controllability and reproducibility, stable storage and good stability
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[0014] 10gN-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-N'-{2-[(3-{2-[(2 -Hydroxyethyl)thio]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio]benzyl}urea was refluxed in 100ml ethyl acetate and heated To 40°C, add 100ml of solvent tert-butyl methyl ether, cool down to zero at a rate of 2°C / min, filter, and vacuum-dry to obtain crystal B. Using Cu-Kα radiation, X-ray powder diffraction expressed in 2θ angles as figure 1 As shown, the HPLC purity was 99.92%.
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