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Atmospheric pressure ion source interface of mass spectrometer

An atmospheric pressure, mass spectrometer technology, applied in the field of devices in the vacuum region, can solve the problems of reduced heat transfer and reduced sensitivity

Inactive Publication Date: 2016-06-15
BRUKER DALTONICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when the diameter of the interface pore increases to a certain extent, the heat transfer through the particles and gaseous species will decrease, and insufficient desolvation will ensue, i.e., the sensitivity will decrease for different reasons

Method used

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  • Atmospheric pressure ion source interface of mass spectrometer
  • Atmospheric pressure ion source interface of mass spectrometer
  • Atmospheric pressure ion source interface of mass spectrometer

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Embodiment Construction

[0033] figure 1 A schematic diagram of the set of four steps (2), (4), (6), (8) is shown, in which the analysis sample contained in the liquid is initially separated (2 ). The eluent from the separation device is transported to the atmospheric pressure ion source (4) for atomization / vaporization and ionization. A gas sample (usually accompanied by particulate matter in droplet form) is transferred from the ion source region via interface (6) to the (first) vacuum region of the mass spectrometer (8), where ions and residual gas are further separated. Finally, the ions to be analyzed enter the mass spectrometer (8) and are measured.

[0034] Those skilled in the art are familiar with current HPLC and CE techniques, so further details need not be discussed here. The same applies to the different types of mass spectrometers (8) that can be used in this arrangement. Examples include single quadrupole mass analyzers, triple quadrupole mass analyzers, radio frequency (RF) ion tra...

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Abstract

The invention relates to a mass spectrometer which is provided with an ion source region having actual atmospheric pressure, wherein the ions are formed by liquid samples. The mass spectrometer is also provided with an interface which is used for transferring ions from the ion source region to a vacuum region with pressure far lower than the atmospheric pressure, to perform further treatment to the formed ions. The interface comprises a wall which is used for separating the ion source region and the vacuum region, and the wall is provided with a central hole formed therein for gas and particulate matters entering the vacuum regions under the effect of pressure gradient, wherein the central point is surrounded by multiple side holes sectionally.

Description

technical field [0001] The present invention relates to an apparatus for delivering ions from an atmospheric pressure ion source (API) to the vacuum region of a mass spectrometer. Background technique [0002] Gas inlet systems are known for API interfaces, e.g., in a liquid chromatograph-mass spectrometer (LC / MS) arrangement, to convey eluent ionized at atmospheric pressure from a high-performance liquid chromatograph (HPLC) to The first vacuum region of the mass spectrometer. Capillaries and orifices can be used in this gas inlet system. Obviously, in addition to the suction speed of the first vacuum zone, the diameter of the small hole and the diameter and length of the capillary will also determine the flux of ions, the amount of residual gas and the pressure of the first vacuum zone. [0003] Capillary interfaces are generally considered to have the advantage of improved heat transfer in flowing gases, which allows for a more desirable desolvation process, i.e., vapor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/04H01J49/34
CPCH01J49/045H01J49/34H01J49/04H01J49/165H01J49/24
Inventor 毛里奇奥·斯普伦多雷史帝芬·扎农
Owner BRUKER DALTONICS INC