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Use of glucosamine-enriched plant compositions

A technology of glucosamine and composition, which is applied in the field of glucosamine-rich plant composition and biocide, which can solve the problems of impaired barrier function and insufficient limitation of bacterial proliferation and infection

Inactive Publication Date: 2016-06-15
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, in atopic dry skin or damaged skin with impaired barrier function, the innate immune response may not be sufficient to limit bacterial proliferation and infection

Method used

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  • Use of glucosamine-enriched plant compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1: the preparation of the plant composition (plant water infusion extract) rich in glucosamine

[0080] 200 g of commercially available dried chicory root cuts (0.5×0.5×0.5 cm) were soaked in 0.5M ammonium sulfate solution for 3 hours. After the solution has drained, the cut pieces are placed in the container with the lid placed directly over the container. Then, this closed container was placed in an oven (Binder) at a temperature of 75° C. for 48 hours.

[0081] The container was then opened and the cuts were spread out (10 cm cut layer) for drying in the same oven, maintained at 75°C.

[0082] 2 g of powdered processed chicory root were extracted with 200 mL of water for 30 minutes at room temperature. After centrifugation, the supernatant was freeze-dried.

[0083] The obtained glucosamine-rich plant composition is the plant water extract (hereinafter referred to as compound A).

Embodiment 2

[0084] Embodiment 2: Preparation of glucosamine-rich plant composition (plant hydroalcoholic extract)

[0085] 200 g of commercially available dried chicory root cuts (0.5×0.5×0.5 cm) were soaked in 0.5M ammonium sulfate solution for 3 hours. After the solution has drained, the cut pieces are placed in the container with the lid placed directly over the container. Then, this closed container was placed in an oven (Binder) at a temperature of 75° C. for 48 hours.

[0086] The container was then opened and the cuts were spread out (10 cm cut layer) for drying in the same oven, maintained at 75°C.

[0087] 20 g of powdered processed chicory roots were extracted with 100 mL of water:ethanol (50:50) for 60 minutes at room temperature. After centrifugation, ethanol in the liquid phase was removed using a rotary evaporator, and the resulting aqueous solution was freeze-dried.

[0088] The resulting glucosamine-rich plant composition is the plant hydroalcoholic extract (hereinaft...

Embodiment 3

[0089] Embodiment 3: Determination of the biocidal activity of plant water extract and / or plant hydroalcoholic extract

[0090]The following test compounds were prepared using the dried plant extracts obtained in Example 1 and Example 2 (i.e. respectively plant water extract and plant hydroalcoholic extract):

[0091] -Compound A: the glucosamine-rich plant composition obtained in Example 1, which is a plant water extract, with two concentrations of 5 μg / mL and 50 μg / mL;

[0092] -Compound B: the glucosamine-rich plant composition obtained in Example 2, which is a plant hydroalcoholic extract, with two concentrations of 5 μg / mL and 50 μg / mL.

[0093] Each test compound was administered alone or in combination at the two concentrations (i.e., 5 μg / mL or 50 μg / mL) at 37° C., 5% CO 2 Normal human epidermal keratinocytes (NHEK) were cultured in vitro under conditions for 24 hours.

[0094] The culture supernatant was then removed, the cell layer was rinsed with phosphate buffe...

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Abstract

The invention relates to glucosamine-enriched plant compositions and their use as a biocide, for instance, in the treatment of skin diseases and / or mucosal diseases. The invention also concerns the use of glucosamine-enriched plant compositions for preventing and / or reducing body odors.

Description

technical field [0001] The present invention relates to glucosamine-rich herbal compositions and their use as biocides. [0002] The present invention also relates to the use of a glucosamine-rich herbal composition for preventing and / or reducing body odour. Background technique [0003] The use of pure glucosamine in the treatment of joint disorders is extensively described in numerous patents as well as in the scientific literature, often in combination with other compounds or extracts from different natural sources. Pure glucosamine is added as glucosamine hydrochloride or glucosamine sulfate and is derived from shellfish hydrolysis. For example, WO2000 / 0074696 describes "herbal compositions comprising glucosamine and Trypterygium wilfordii, Ligustrum lucidum and / or Erycibesch midtii, for treating inflammation or degradation of joint tissues, e.g. Herbal Composition of Ding Gong Teng) in which pure glucosamine is mixed with herbal preparations. Other patents relate to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K31/7008A61P17/00A61Q19/00
CPCA61K36/28A61Q5/006A61K8/60A61Q11/00A61Q15/00A61Q19/00A61K31/7008A61K8/9789A61P17/00A61K2300/00
Inventor Y·马埃P·E·布朗J·哈森D·库尔图瓦
Owner SOC DES PROD NESTLE SA
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