A liver cancer PDX standardization model base

Abstract

Compared with human source tumor cell line models, PDX model tumors have the differentiated degree, morphological characteristics, structural characteristics and molecular characteristics closer to those of tumors of human bodies, so that an important in-vivo model is provided for biological study of tumors, searching of diagnostic markers and medicine screening. The invention provides a liver cancer PDX standardization model base which contains complete clinical information of patients with live cancer, pathologic types and grades, gene mutation and genetic transcription expression conditions; a patient primary tumor cell line corresponding to the liver cancer PDX model is established at the same time; comprehensive assessment which is nearly clinical is performed on the anti-liver cancer function of medicine on the cell level and the animal level.

Description

technical field

[0001] The invention belongs to the field of biomedicine and relates to a liver cancer PDX standardized model library. Background technique

[0002] PDX (Patient-Derivedtumor Xenograft) human-derived tumor xenograft model refers to the transplantation of fresh tumor tissues from patients into immunodeficient mice, and relies on the microenvironment provided by the mice for growth. Compared with human tumor cell line models, the degree of differentiation, morphological characteristics, structural characteristics and molecular characteristics of PDX model tumors are closer to the characteristics of human tumors, which provides great opportunities for the biological research of tumors, the search for diagnostic markers and Drug screening provides an important in vivo model. In addition, the PDX model can reflect the characteristics of the patient's own tumor from which the specimen was derived, including the specificity of drug response. Therefore, PDX models ...