Novel application of duramen of Acanthopanax giraldii Harms or extract of duramen of Acanthopanax giraldii Harms

A technology of Radix Radix et Rhizoma and extract, applied in the field of medicine, can solve problems such as no reports on Radix Rhizoma Radix Rhizoma, and achieve the effects of significant analgesic efficacy, prolonging the incubation period, and reducing the number of writhings.

Inactive Publication Date: 2016-06-22
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many literature reports on the chemical constituents and pharmacological effects of the bark of Acanthopanax orientalis, but there is no relevant report on the heart of Acanthopanax orientalis

Method used

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  • Novel application of duramen of Acanthopanax giraldii Harms or extract of duramen of Acanthopanax giraldii Harms
  • Novel application of duramen of Acanthopanax giraldii Harms or extract of duramen of Acanthopanax giraldii Harms
  • Novel application of duramen of Acanthopanax giraldii Harms or extract of duramen of Acanthopanax giraldii Harms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 The preparation of the extract of the root of the present invention

[0023] Take an appropriate amount of Acanthopanax sinensis, add 6 times the amount of water, divide it into two decoctions, and decoct for 0.5 hours each time, combine the decoction liquid, and evaporate to dry to obtain the dry cream of Acanthopanax sinica.

Embodiment 2

[0024] Embodiment 2 The preparation of the Radix Acaranthopanax Radix Sinensis Extract of the present invention

[0025] Take an appropriate amount of Acanthopanax sinensis, add 6 times the amount of 80% ethanol, divide into 2 times of reflux, and reflux for 0.5 hours each time, combine the reflux liquid, recover the ethanol, and obtain the dry paste of Acanthopanax japonicus.

[0026] Prove the beneficial effect of the present invention below by concrete pharmacodynamics test.

experiment example 1

[0027] Experimental example 1 Study on the analgesic effect of the extract of Panax radix Radix Sinica

[0028] 1 Experimental materials

[0029] 1.1 Test drugs

[0030] The wood heart of Wujia hongmaojia was provided by the experimental field of Wujia hongmaojia of Chengdu University of Traditional Chinese Medicine (origin: Maoxian), and was identified by the associate researcher Gu Rui of Chengdu University of traditional Chinese medicine as Acanthopanaxgiraldii Harms.

[0031] The extract of Panax notocarpa was prepared according to Example 1.

[0032] 1.2 Experimental animals and experimental venues

[0033] 160 SPF-grade KM mice were provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences. The mice were repurchased and fed for observation for 3 days, and the body weight before the drug was recorded. Full-price feed, free access to food and water. The full-price pellets for mice were provided by the farm of the Sichuan Provincial Experim...

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Abstract

The invention provides application of duramen of Acanthopanax giraldii Harms or extract of the duramen of Acanthopanax giraldii Harms. The duramen of Acanthopanax giraldii Harms or the extract of the duramen of Acanthopanax giraldii Harms is capable of evidently prolonging response latency of mouse writhing reaction and reducing mouse writhing frequency and has a remarkable analgesic efficacy, and the analgesic effect of a low-dose group is superior to that of a high-dose group and is equivalent to that of indometacin which is a classical analgesic medicine. By utilization of duramen, which is conventionally abandoned as a non-medicinal part, of Acanthopanax giraldii Harms, comprehensive development and protection of medicinal resources of Acanthopanax giraldii Harms are significantly promoted, and promising market prospect is realized.

Description

technical field [0001] The invention relates to the new application of the red hair root and its extract, which belongs to the field of medicine. Background technique [0002] Acanthopanax comes from the Araliaceae plant AcanthopanaxgiraldiiHarms and its species of hair stalk A.giraldiiHarmsvar.hispidusHoo. Its main production area is Sichuan, and it is mainly distributed in the upper reaches of the Minjiang River: Jinchuan, Xiaojin, Jiuzhaigou, Heishui, Maoxian, Wenchuan, Hongyuan and other counties. In recent years, domestic scholars have done related research on the chemical constituents and pharmacological effects of Acanthopanax bark. Studies have shown that there are more than 100 chemical constituents of Angus radix. It mainly belongs to glycosides, terpenes, polysaccharides, alkanes and organic acids. Representative glycoside components include syringol glucoside, eleutherosides B, D, E, carotin, guanosine, adenosine, nucleoside, and the like. According to modern...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61P29/00
CPCA61K36/254A61K2236/331A61K2236/333A61K2236/39
Inventor 古锐钟世红
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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