Euphorbium active tetracyclic triterpene composition and preparation method and use thereof

A technology for tetracyclic triterpenes and spurge fats, which is applied to the active tetracyclic triterpenes composition of spurge fats and the fields of preparation and application thereof, can solve the problems of extraction and purification process and further research on pharmacological effects, and achieve good anti-inflammatory effects. Analgesic effect, reducing the number of writhing, prolonging the latency effect

Inactive Publication Date: 2021-02-05
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no research report on the extraction and purification of active tetracyclic triterpenes in Euphorbia, so the extraction and purification process and pharmacological effects of active tetracyclic triterpenoids in Euphorbia need to be further studied

Method used

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  • Euphorbium active tetracyclic triterpene composition and preparation method and use thereof
  • Euphorbium active tetracyclic triterpene composition and preparation method and use thereof
  • Euphorbium active tetracyclic triterpene composition and preparation method and use thereof

Examples

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Embodiment 1

[0021] Embodiment 1: The composition of the active tetracyclic triterpenes of Euphorbia jelly, comprising 70% to 90% by weight of Euphorbia jelly active tetracyclic triterpenes, and the active tetracyclic triterpenes of Euphorbia jelly include Euphorbia oleifera and euphorbia Euphorbia alcohol, wherein, the weight percent of Euphorbia alcohol content is 35% to 40%, and the weight percent of Euphorbia alcohol content is 15% to 20%.

Embodiment 2

[0022] Example 2: The active tetracyclic triterpenoid composition of Euphorbia jelly, comprising 70% or 90% by weight of Euphorbia jelly-active tetracyclic triterpenes, and Euphorbia jelly-active tetracyclic triterpenes include Euphorbia oleifera and Euphorbia jelly Euphorbia alcohol, wherein, the weight percent of Euphorbia alcohol content is 35% or 40%, and the weight percent of Euphorbia alcohol content is 15% or 20%.

Embodiment 3

[0023] Embodiment 3: As the optimization of the above-mentioned embodiment, it is prepared according to the following method: the first step, the resinous secretion of the required amount of Euphorbiaceae plant polylipid sprigs is 75% to 95% by volume percentage. The ethanol solution is refluxed for 1 to 3 times, and the extracts are combined to recover ethanol and concentrate under reduced pressure to obtain an extract, wherein the volume of ethanol added to each 1 g of Euphorbia is 5ml to 20ml; After the ethanol solution with a percentage of 75% to 95% is dissolved, the sample is mixed with silica gel, and then adsorbed on a silica gel column, first eluted with petroleum ether for 2 to 5 column volumes, and then with 3% to 6% ethyl acetate-petroleum The ether solution is eluted for 5 to 7 column volumes, 3% to 6% of the ethyl acetate-petroleum ether solution eluent is collected, concentrated under reduced pressure and dried in vacuo to obtain the Euphorbia active tetracyclic ...

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Abstract

The present invention relates to the technical field of extraction and purification of active tetracyclic triterpene compositions from euphorbium, in particular to an euphorbium active tetracyclic triterpene composition and a preparation method and use thereof. The euphorbium active tetracyclic triterpene composition comprises 70%-90% by weight of euphorbium active tetracyclic triterpene, the euphorbium active tetracyclic triterpene comprises euphadienol and euphol. The preparation method comprises the following steps: carrying out reflux extraction on eeuphorbium in an ethanol solution and vacuum concentration to obtain an extract, dissolving the extract in the ethanol solution, stirring the dissolved extract with silica gel, carrying out adsorbing with a silica gel column, and collectingan eluate to obtain the euphorbium active tetracyclic triterpene composition. The preparation method has characteristics of low cost, no pollution and suitability for industrialization, and the obtained euphorbium active tetracyclic triterpene composition has good anti-inflammatory and analgesic effects, can relieve auricle swelling of mice caused by xylene, improves a pain stasis value of a mouse pain model caused by a hot plate method, can prolong a mouse twisting incubation period caused by acetic acid, significantly reduce the number of twisting of mice and can be used to prepare anti-inflammatory and analgesic drugs.

Description

technical field [0001] The invention relates to the technical field of extracting and purifying active tetracyclic triterpenoid composition from Euphorbia oil, and relates to a Euphorbia oil active tetracyclic triterpenoid composition and a preparation method and application thereof. Background technique [0002] Euphorbium is the resinous secretion of Euphorbiaresinifera Berger., a plant of Euphorbiaceae Euphorbiaceae. It is a commonly used medicinal material in Uyghur medicine. It is native to Europe and Africa, and is also distributed in the United Kingdom and the former Soviet Union. This product was first recorded in the "Medicine" written by Avicenna, "British Pharmacopoeia" (1949 edition), "Soviet Pharmacopoeia" (1959 edition) also included. At the edge of the plant stem, cut the skin with a quick knife, collect the milk that flows out, store it in a bottle after drying, and then it can be used for medicinal purposes. Euphorbia has the functions of generating dryness...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61K31/575A61P19/02A61P29/00A61P27/12
CPCA61K31/575A61K36/47A61K2236/333A61K2236/55A61P19/02A61P27/12A61P29/00A61K2300/00
Inventor 顾政一赵军李晨阳徐芳胡旭
Owner XINJIANG INST OF MATERIA MEDICA
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