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Eye drops of raw material marine organism

A technology of marine organisms and eye drops, which is applied in the direction of drug combination, drug delivery, organic active ingredients, etc., can solve the problems of short residence time of drug active ingredients, low drug bioavailability, no antibacterial and antibacterial effects, etc., to achieve Promote epithelial healing, relieve and treat dry eye, and stabilize good results

Inactive Publication Date: 2016-07-06
菏泽医学专科学校
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the medicine of this type of preparation is instilled into the eyes, the residence time of the active ingredient of the medicine is short, and the bioavailability of the medicine is low
The second is to make the active ingredient of the drug into a paste. Although this preparation prolongs the residence time of the active ingredient of the drug in the eyes, it is very inconvenient to use
However, enhancers such as hyaluronic acid have no antibacterial and antibacterial effects.

Method used

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  • Eye drops of raw material marine organism
  • Eye drops of raw material marine organism
  • Eye drops of raw material marine organism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Include the following steps:

[0021] (1) Add 60ml of distilled water into a clean glass container, weigh 2.0g of carboxymethyl chitosan, 1.0g of chondroitin sulfate, 0.1g of N-acetylglucosamine and 0.6g of sodium chloride in distilled water, stir and dissolve for later use use;

[0022] (2) Adjust the pH of disodium hydrogen phosphate or sodium dihydrogen phosphate in the solution prepared above to 7.0-7.2, and add distilled water to make the volume to 100ml;

[0023] (3) Filter the solution prepared in step (2) through a 3 μm filter membrane, and then sterilize the filtrate by moist heat sterilization or instant high temperature sterilization.

Embodiment 2

[0025] Include the following steps:

[0026] (1) Add 60ml of distilled water into a clean glass container, weigh 0.8g of carboxybutyl chitosan, 0.5g of chondroitin sulfate, 1.0g of N-acetylglucosamine and 0.7g of sodium chloride in distilled water, stir and dissolve for later use use;

[0027] (2) Adjust the pH of 0.1mol / L NaOH or 0.1mol / L HCl solution in the solution prepared above to 7.2-7.4, add distilled water to make the volume to 100ml;

[0028] (3) Filter the solution prepared in step (2) through a 3 μm filter membrane, and then sterilize the filtrate by moist heat sterilization or instant high temperature sterilization.

Embodiment 3

[0030] Include the following steps:

[0031] (1) Add 60ml of distilled water into a clean glass container, weigh 1.5g of hydroxyethyl chitosan, 1.0g of N-acetylglucosamine and 0.9g of sodium chloride in distilled water, stir and dissolve for later use;

[0032] (2) Adjust the pH of 0.1mol / L NaOH or 0.1mol / L HCl solution in the solution prepared above to 7.2-7.4, add distilled water to make the volume to 100ml;

[0033] (3) Filter the solution prepared in step (2) through a 3 μm filter membrane, and then sterilize the filtrate by moist heat sterilization or instant high temperature sterilization.

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Abstract

The invention relates to eye drops and particularly relates to eye drops of raw material marine organism. A preparation method of the eye drops of raw material marine organism comprises the following steps: (1) adding distilled water into a clean glass container, weighing a chitosan derivative, chondroitin sulfate, N-acetylglucosamine and sodium chloride and adding into the distilled water, and stirring for dissolution for later use; (2) adding a pH regulator into the obtained solution to adjust the pH to 7.0-7.4; and (3) filtering the solution prepared in the step (2) with a 3mu m filter membrane, and sterilizing the filtrate by moist heat sterilization or flash pasteurization. In the invention, due to the chitosan derivative, the eye drops have the functions of promoting epithelium healing, reducing cicatrization, inhibiting bacteria, relieving pain, stopping bleeding and the like; and moreover, the eye drops have good biocompatibility and can be degraded and absorbed while the degradation product does not cause any toxic or side effects. The eye drops provided by the invention have the advantages of good stability, high safety and high comfort and realize a perfect curative effect on dry eye syndrome, keratitis, cornea trauma and the like.

Description

(1) Technical field [0001] The invention relates to an eye drop, in particular to a marine biological raw material eye drop. (2) Background technology [0002] With the acceleration of the pace of life, the abnormal climate and the increase of computer usage, the incidence of eye discomfort, eye fatigue, and even eye diseases is getting higher and higher. At present, there are mainly three types of eye drops for the clinical treatment of eye diseases. One is to dissolve antibiotics or antiviral drugs directly in distilled water and use them at a certain concentration. After the medicine of this type of preparation is instilled into the eyes, the residence time of the active ingredient of the medicine is short, and the bioavailability of the medicine is low. The second is to make the active ingredient of the medicine into a paste. Although this preparation prolongs the residence time of the active ingredient of the medicine in the eyes, it is very inconvenient for practical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K31/722A61K31/7008A61K9/08A61P27/02A61P27/04A61P31/04
CPCA61K31/737A61K9/0048A61K9/08A61K31/7008A61K31/722A61K2300/00
Inventor 杨朝忠
Owner 菏泽医学专科学校
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