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Pharmaceutical preparation for treating first-trimester threatened abortion with anticardiolipin antibody positive

A cardiolipin antibody and pharmaceutical preparation technology, which is applied in the field of traditional Chinese medicine, can solve problems such as thrombocytopenia, infection, and miscarriage, and achieve the effects of precise and reasonable drug compatibility, safe and reliable curative effect, and obvious toxic and side effects

Inactive Publication Date: 2016-07-06
王盛梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, ACA in the first trimester can interfere with the fusion of cytotrophoblast and syncytiotrophoblast and the growth and development of amniotic membrane, resulting in miscarriage
[0004] At present, in the treatment of threatened abortion caused by ACA, immunosuppressants (prednisone or prednisone, etc.) combined with anticoagulant drugs (aspirin or heparin, etc.) are often used at home and abroad, but long-term use can cause blood sugar and osteoporosis. , infection, thrombocytopenia, bleeding and other side effects

Method used

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  • Pharmaceutical preparation for treating first-trimester threatened abortion with anticardiolipin antibody positive
  • Pharmaceutical preparation for treating first-trimester threatened abortion with anticardiolipin antibody positive
  • Pharmaceutical preparation for treating first-trimester threatened abortion with anticardiolipin antibody positive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 capsule

[0032] Prescription: 15 parts of psoralen, 12 parts of Acanthopanax, 8 parts of Pteris seven, 20 parts of medlar, 12 parts of Geshanxiao, 8 parts of willow parasite, 12 parts of scissors rattan, 10 parts of salvia, 15 parts of hairy potato, 8 parts of madder.

[0033] Preparation method: decoct psoraleae, acanthopanax, Pteris seven, medlar, Geshanxiao, willow parasitic, scissors rattan, salvia miltiorrhiza, hairy potato, and madder with water for two times, adding water for the first time is 1 / 2 by weight of medicinal materials 6 times, decocting for 1.0-1.5 hours, adding water for the second time is 5 times the weight of the medicinal materials and decocting for 1.5-2.0 hours, combining the decoction, filtering, and concentrating the filtrate under reduced pressure to obtain a thick paste with a relative density of 1.07 (65°C When measured), add ethanol to make the alcohol content reach 35%, stir well, refrigerate at -5-0°C for 8-12 hours, filte...

Embodiment 2

[0034] Embodiment 2 capsules

[0035] Prescription: 13 parts of psoralen, 15 parts of Acanthopanax, 11 parts of Pteris seven, 15 parts of medlar, 15 parts of Geshanxiao, 8 parts of willow parasite, 10 parts of scissors, 8 parts of salvia, 15 parts of hairy potato, 8 parts of madder.

[0036] Preparation method: decoct psoraleae, acanthopanax, Pteris seven, medlar, Geshanxiao, willow parasitic, scissors rattan, salvia miltiorrhiza, hairy potato, and madder with water for two times, adding water for the first time is 1 / 2 by weight of medicinal materials 4 times, decocting for 1.0-1.5 hours, adding water for the second time is 5 times the weight of the medicinal materials and decocting for 1.5-2.0 hours, combining the decoction, filtering, and concentrating the filtrate under reduced pressure to obtain a thick paste with a relative density of 1.05 (65°C When measured), add ethanol to make the alcohol content reach 35%, stir well, refrigerate at -5-0°C for 8-12 hours, filter, rec...

Embodiment 3

[0037] Embodiment 3 capsules

[0038] Prescription: 15 parts of psoralen, 15 parts of Acanthopanax, 8 parts of Pteris seven, 20 parts of medlar, 10 parts of Geshan Xiao, 5 parts of willow parasite, 15 parts of scissors, 7 parts of salvia, 18 parts of hairy potato, 10 parts of madder.

[0039] Preparation method: decoct psoraleae, acanthopanax, Pteris seven, medlar, Geshanxiao, willow parasitic, scissors rattan, salvia miltiorrhiza, hairy potato, and madder with water for two times, adding water for the first time is 1 / 2 by weight of medicinal materials 8 times, decocting for 1.0-1.5 hours, adding water for the second time is 3 times the weight of medicinal materials and decocting for 1.5-2.0 hours, combining the decoction, filtering, and concentrating the filtrate under reduced pressure to obtain a thick paste with a relative density of 1.08 (65°C When measured), add ethanol to make the alcohol content reach 35%, stir well, refrigerate at -5-0°C for 8-12 hours, filter, recove...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical preparation for treating early threatened abortion with positive anticardiolipin antibody and a preparation method thereof. The medicinal preparation is prepared from psoralen, Acanthopanax senticosus, Fengwei Qi, Lycium barbarum, Geshanxiao, willow parasitic, sagebrush, salvia, hairy potato and madder as medicinal raw materials. The whole recipe has few medicinal flavors, but the compatibility is reasonable, it can nourish the kidney and spleen, nourish the congenital in the future, qi to carry the fetus, blood to nourish the fetus, and tonic in the same day and day, so there is no damage. , No obvious toxic and side effects were found for mothers and infants, showing the great advantages of traditional Chinese medicine in the treatment of early threatened abortion, and it is worthy of further research and application.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical preparation for treating early threatened abortion with anticardiolipin antibody positive and a preparation method thereof. Background technique [0002] Threatened miscarriage refers to a small amount of vaginal bleeding before the 28th week of pregnancy, usually dark red or bloody leucorrhea, without pregnancy discharge, followed by paroxysmal lower abdominal pain or low back pain. Gynecological examination shows that the cervix is ​​not dilated, the membranes are not broken, and the size of the uterus is consistent with the number of weeks of menopause. After rest and treatment, the symptoms disappear, and the pregnancy can continue; if the amount of vaginal bleeding increases or the lower abdominal pain intensifies, it may develop into inevitable miscarriage. Threatened miscarriage occurs in about 20% of pregnant women, and half of them can further ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P15/06A61P13/12A61P1/14A61P7/00
CPCA61K36/487A61K36/185A61K36/254A61K36/27A61K36/41A61K36/537A61K36/74A61K36/815A61K36/8945A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 王盛梅
Owner 王盛梅
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