A water-soluble ivermectin oral liquid for veterinary use and a preparing method thereof

A technology for ivermectin and oral liquid, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problem of low solubility, achieve good absorption, low production cost, and long shelf life Effect

Inactive Publication Date: 2016-07-13
CHONGQING BULL ANIMAL PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ivermectin has low solubility in water but high fat solubility, so all ivermectin oral solutions on the market are oil oral solutions
So far, there is no ivermectin water-soluble oral solution at home and abroad, and it can be expected that the ivermectin water-soluble oral solution has a broad market prospect

Method used

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  • A water-soluble ivermectin oral liquid for veterinary use and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of the veterinary ivermectin water-soluble oral liquid of the present embodiment may further comprise the steps:

[0031] (1) Accurately weigh 80g of ivermectin, stir and dissolve it with 900mL of ethyl acetate, then add 10L of Tween-80, stir well, then add water while stirring;

[0032] (2) Dissolve 1g of thimerosal in water and add it to the solution system in step (1). After stirring evenly, add water to make up to 100L, add 450g of disodium hydrogen phosphate and 400g of sodium dihydrogen phosphate, adjust the pH value to 6.2, filter , to obtain veterinary ivermectin water-soluble oral liquid.

Embodiment 2

[0034] The preparation method of the veterinary ivermectin water-soluble oral liquid of the present embodiment may further comprise the steps:

[0035] (1) Accurately weigh 50g of ivermectin, stir and dissolve it with 400mL of ethyl acetate, then add 6L of Tween-80, stir well, then add water while stirring;

[0036] (2) Dissolve 0.5g of thimerosal in water and add it to the solution system in step (1). After stirring evenly, add water to make the volume to 100L, add 300g of disodium hydrogen phosphate and 400g of sodium dihydrogen phosphate, and adjust the pH value to 5.8. Filter to obtain the veterinary ivermectin water-soluble oral liquid.

Embodiment 3

[0038] The preparation method of the veterinary ivermectin water-soluble oral liquid of the present embodiment may further comprise the steps:

[0039] (1) Accurately weigh 150g of ivermectin, stir and dissolve it with 1.5L of ethyl acetate, then add 15L of Tween-80, stir well, then add water while stirring;

[0040] (2) Dissolve 50g of thimerosal in water and add it to the solution system in step (1). After stirring evenly, add water to make up to 100L, add 900g of disodium hydrogen phosphate and 800g of sodium dihydrogen phosphate, adjust the pH value to 6.5, filter , to obtain veterinary ivermectin water-soluble oral liquid.

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Abstract

A water-soluble ivermectin oral liquid for veterinary use and a preparing method thereof are disclosed. Each 1000 mL of the oral liquid comprises 0.1-2 g of ivermectin, 1-20 mL of ethyl acetate, 50-150 mL of Tween-80, 1-10 g of sodium hydrogen phosphate, 1-10 g of sodium dihydrogen phosphate and 0.001-1 g of thiomersal, with the balance being water. The oral liquid adopts the water as a solvent, the ivermectin is low in solubility in water, but a solution can be uniform through adding the water after the ethyl acetate and the tween-80 which are high in dose are utilized to promote solution of the ivermectin, and therefore the ivermectin oral liquid is uniform, stable and long in shelf life, and is nonirritant to mouth mucosa, lower in production cost and good in absorption when being compared to oil oral liquids.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to a veterinary ivermectin water-soluble oral liquid and a preparation method thereof. Background technique [0002] Nematode disease usually occurs when the resistance of livestock is reduced or malnutrition. The nematodes parasitic in cattle, sheep and other livestock can continuously absorb their nutrients and release toxins, thereby reducing the body's immunity, causing emaciation, anemia, rough coat and other symptoms , Severe infection can cause a large number of deaths. When nematode worms parasitize and migrate in the host, they often cause serious mechanical damage and stimulation to the host, causing bleeding and inflammation. [0003] In the 1980s, the American MERCK company successfully developed abamectin and ivermectin into veterinary antiparasitic drugs, which were used to drive and kill parasites such as internal nematodes and external parasites...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61P33/10
Inventor 吴俊伟姜波陈红伟邓开峰
Owner CHONGQING BULL ANIMAL PHARMA
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