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Application of usnea or extract thereof in preparation of medicine for treating and/or preventing abnormal lipids metabolism

A technology of abnormal lipid metabolism and extracts, applied in metabolic diseases, drug combinations, plant/algae/fungus/moss components, etc., can solve problems such as difficult to achieve long-term treatment and prevention, abnormal lipid metabolism, and inaccurate curative effect , to achieve the effect of prevention and treatment of abnormal lipid metabolism, broad clinical application prospects, and prevention and treatment of hyperlipoproteinemia

Inactive Publication Date: 2016-07-13
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used drugs for the treatment of hyperlipidemia are: bile acid complexing agents, statins (statins), steroid derivatives sitosterol, niacin, benzoic acids, polyunsaturated fatty acids, mucopolysaccharides and polysaccharides , estrogen; the cost of these drugs is relatively high, and most of them have inaccurate curative effects. Long-term application has certain side effects, such as gastrointestinal symptoms, neurological symptoms, endocrine symptoms, cardiovascular and cerebrovascular symptoms, etc., and the weight and blood lipids rebound quickly after stopping the drug. It is difficult to achieve the purpose of long-term treatment and prevention
At present, there is no relevant report on using Usnea to prevent and treat abnormal lipid metabolism

Method used

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  • Application of usnea or extract thereof in preparation of medicine for treating and/or preventing abnormal lipids metabolism
  • Application of usnea or extract thereof in preparation of medicine for treating and/or preventing abnormal lipids metabolism
  • Application of usnea or extract thereof in preparation of medicine for treating and/or preventing abnormal lipids metabolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 Usnea water extract of the present invention

[0021] Weigh 250g of Usnea crude drug, crush it, add distilled water to decoct, a total of 3 times: add 2000ml of water for the first time, decoct for 30min from boiling, filter to obtain the medicinal liquid; Dregs plus 1000ml of distilled water decocted for 20min, filtered to get the liquid; combined 3 filtrates, concentrated, to get Usnea water extract of the present invention.

Embodiment 2

[0022] The preparation of embodiment 2 Usnea alcohol extract of the present invention

[0023] Take by weighing the Usnea crude drug of 250g, pulverize, take 80% ethanol aqueous solution as solvent leaching twice: first time add 6 times of solvent (1500ml) and impregnate for 24 hours, filter, get medicinal liquid; ) leached for 12 hours, filtered, got the medicinal solution, combined twice the medicinal solution, concentrated with a rotary evaporator, and dried for 48 hours to obtain the extract powder 12.07g of Usnea alcohol extract of the present invention, with a yield of 4.828%.

[0024] Prove the beneficial effects of the present invention below by drug effect experiment.

experiment example 1

[0025] Experimental example 1 Usnea water extract and ethanol extract of the present invention promote lipid metabolism experiment

[0026] 1 Experimental materials

[0027] 1.1 Experimental animals

[0028] SPF grade SD rats, half male and half female, weighing 170±10 g, were provided by Chengdu Dashuo Biotechnology Co., Ltd., batch number: 0016522.

[0029] 1.2 Experimental drugs

[0030] Usnea: purchased from Hehuachi Herb Market in Chengdu.

[0031] Simvastatin tablets: Suzhou First Pharmaceutical Co., Ltd., specifications: 20mg / tablet, production batch number: 150214.

[0032] 1.3 Experimental Instruments

[0033] DJZ Traditional Chinese Medicine Pulverizer (Shanghai Dianjiu Traditional Chinese Medicine Machinery Manufacturing Co., Ltd.), SK8200LH Ultrasonic Cleaner (Shanghai Kedao Ultrasonic Instrument Co., Ltd.), RE52-86A Rotary Evaporator (Shanghai Yarong Biochemical Instrument Factory), Laboratory Ultrapure Water System (Chengdu Tangshi Corning Technology Develo...

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PUM

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Abstract

The invention discloses application of usnea or extract thereof in preparation of a medicine for treating and / or preventing abnormal lipids metabolism. Pharmacological experiments indicate that usnea aqueous extract and alcohol extract can be used for remarkably reducing rise of serum and liver triglyceride and low density lipoprotein and increasing serum high density lipoprotein so as to prevent and treat hyperlipoproteinemia and atherosclerosis. Furthermore, the usnea alcohol extract can be used for remarkably reducing the content of TBA, ALT and AST of serum, and the usnea aqueous extract can be used for reducing the content of AST of serum and protecting liver injury caused by lipid metabolism disorders and has an effect of preventing and treating fatty liver. Usnea is wide in source, has an exact pharmacological effect for preventing and treating abnormal lipids metabolism, and has wide clinical application prospect.

Description

technical field [0001] The invention relates to a new application of usnea or its extract, belonging to the field of medicine. Background technique [0002] Abnormal lipid metabolism is an abnormality in the quality and quantity of lipids and their metabolites in blood and other tissues and organs caused by congenital or acquired factors, and its specific diseases mainly include hyperlipoproteinemia. This type of disease is extremely harmful to human health: excessive lipids in the blood are deposited on the smooth intima of the arteries, and white plaques formed by accumulation of lipids similar to atherosclerosis appear, that is, atherosclerotic lesions; Severe cases can also cause pancreatitis, coronary heart disease, angina pectoris, acute myocardial infarction, and stroke. [0003] At present, the commonly used drugs for the treatment of hyperlipidemia are: bile acid complexing agents, statins (statins), steroid derivatives sitosterol, niacin, benzoic acids, polyunsatu...

Claims

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Application Information

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IPC IPC(8): A61K36/09A61P3/06A61P3/04A61P1/16A61P9/10
CPCA61K36/09A61K2236/331A61K2236/333A61K2236/39
Inventor 闫智勇朱家丽许科科张雪梅张天娥
Owner SOUTHWEST JIAOTONG UNIV
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