Pseudo-ginseng transformed saponin, as well as antifungal medicine composition, preparation method and application thereof
A technology for antifungal drugs and saponin conversion, which is applied in the direction of drug combinations, antifungal agents, and non-active ingredients of polymer compounds, and can solve problems such as human and environmental hazards, safety and environmental pollution, and unstable product output. Achieve the effect of not easy to relapse, obvious effect, and accelerate skin recovery
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Embodiment 1
[0031] like figure 1 The preparation method of the shown Panax notoginseng transformed saponin collection map is as follows:
[0032] (1) Panax notoginseng total saponins, treated at high temperature in an autoclave for 2 hours, and the treatment temperature is 120°C;
[0033] (2) After dissolving in appropriate distilled water, purify and enrich by HP-20 macroporous resin, elute with water and 95% ethanol water respectively, and the elution volume is 5 column volumes;
[0034] (3) Collect 95% ethanol eluting components, rotary steaming temperature 50 ° C, vacuum degree 0.02Pa, rotary steaming until odorless, freeze-drying, and obtain 95% ethanol water elution solid component powder; obtain the notoginseng converted saponins .
[0035] (4) Radix Notoginseng conversion saponin obtained through technological treatment: Pk 3 24.9%, Rh 4 35.5%, Rh 5 The content of rare saponins such as 20.2% is greatly increased, and the content of transformed rare ginsenosides is above 70%. ...
Embodiment 2
[0037] The preparation method of notoginseng converted saponin comprises the following steps:
[0038] (1) Panax notoginseng total saponins, treated at high temperature in an autoclave for 5 hours, and the treatment temperature was 140°C;
[0039] (2) After dissolving in appropriate distilled water, purify and enrich through HP-20 macroporous resin, and elute with water and 95% ethanol water respectively, and the elution volume is 1 column volume;
[0040] (3) Collect 95% ethanol eluting components, rotary steaming temperature 80°C, vacuum degree 0.1MPa, rotary steaming until odorless, freeze-drying, and obtain 95% ethanol water elution solid component powder; obtain the notoginseng converted saponins .
Embodiment 3
[0042] The preparation method of notoginseng converted saponin comprises the following steps:
[0043] (1) Panax notoginseng total saponins, high temperature treatment 3.5 hours in autoclave, treatment temperature is 130 ℃;
[0044](2) After dissolving in appropriate distilled water, purify and enrich by HP-20 macroporous resin, and elute with water and 95% ethanol water respectively, and the elution volume is 3 column volumes;
[0045] (3) Collect 95% ethanol eluting components, rotary steaming temperature 60°C, vacuum degree 0.06MPa, rotary steaming until odorless, freeze-drying, and obtain 95% ethanol water elution solid component powder; obtain the notoginseng converted saponins .
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