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Pseudo-ginseng transformed saponin, as well as antifungal medicine composition, preparation method and application thereof

A technology for antifungal drugs and saponin conversion, which is applied in the direction of drug combinations, antifungal agents, and non-active ingredients of polymer compounds, and can solve problems such as human and environmental hazards, safety and environmental pollution, and unstable product output. Achieve the effect of not easy to relapse, obvious effect, and accelerate skin recovery

Active Publication Date: 2016-07-13
INST OF CROP SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, high-temperature acid treatment or alkaline treatment requires the application of acid and alkali, which itself has problems such as safety and environmental pollution; although microbial degradation treatment and enzyme treatment have mild conditions, the product output is unstable; chemical chromatography often uses organic solvents , more harmful to the human body and the environment to be eliminated

Method used

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  • Pseudo-ginseng transformed saponin, as well as antifungal medicine composition, preparation method and application thereof
  • Pseudo-ginseng transformed saponin, as well as antifungal medicine composition, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] like figure 1 The preparation method of the shown Panax notoginseng transformed saponin collection map is as follows:

[0032] (1) Panax notoginseng total saponins, treated at high temperature in an autoclave for 2 hours, and the treatment temperature is 120°C;

[0033] (2) After dissolving in appropriate distilled water, purify and enrich by HP-20 macroporous resin, elute with water and 95% ethanol water respectively, and the elution volume is 5 column volumes;

[0034] (3) Collect 95% ethanol eluting components, rotary steaming temperature 50 ° C, vacuum degree 0.02Pa, rotary steaming until odorless, freeze-drying, and obtain 95% ethanol water elution solid component powder; obtain the notoginseng converted saponins .

[0035] (4) Radix Notoginseng conversion saponin obtained through technological treatment: Pk 3 24.9%, Rh 4 35.5%, Rh 5 The content of rare saponins such as 20.2% is greatly increased, and the content of transformed rare ginsenosides is above 70%. ...

Embodiment 2

[0037] The preparation method of notoginseng converted saponin comprises the following steps:

[0038] (1) Panax notoginseng total saponins, treated at high temperature in an autoclave for 5 hours, and the treatment temperature was 140°C;

[0039] (2) After dissolving in appropriate distilled water, purify and enrich through HP-20 macroporous resin, and elute with water and 95% ethanol water respectively, and the elution volume is 1 column volume;

[0040] (3) Collect 95% ethanol eluting components, rotary steaming temperature 80°C, vacuum degree 0.1MPa, rotary steaming until odorless, freeze-drying, and obtain 95% ethanol water elution solid component powder; obtain the notoginseng converted saponins .

Embodiment 3

[0042] The preparation method of notoginseng converted saponin comprises the following steps:

[0043] (1) Panax notoginseng total saponins, high temperature treatment 3.5 hours in autoclave, treatment temperature is 130 ℃;

[0044](2) After dissolving in appropriate distilled water, purify and enrich by HP-20 macroporous resin, and elute with water and 95% ethanol water respectively, and the elution volume is 3 column volumes;

[0045] (3) Collect 95% ethanol eluting components, rotary steaming temperature 60°C, vacuum degree 0.06MPa, rotary steaming until odorless, freeze-drying, and obtain 95% ethanol water elution solid component powder; obtain the notoginseng converted saponins .

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PUM

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Abstract

The invention discloses pseudo-ginseng transformed saponin, as well as an antifungal medicine composition, a preparation method and application thereof. The preparation method of the pseudo-ginseng transformed saponin comprises the main steps of high-temperature treatment, rotary evaporation, macro-porous resin purification enrichment and elution. The composition comprises the following components in parts by weight: 0.5-50 parts of pseudo-ginseng transformed saponin and 50-99.5 parts of conventional medicinal auxiliary or nursing auxiliary, and has excellent bacterium inhibiting and sterilizing effects. The medicine and skin-nursing product can be used for radically killing pathogenic fungi, has a remarkable curative effect for tinea manuum, tinea pedis, oral ulcer, black nails and other problems caused by skin fungi, and is a safe pure traditional Chinese medicine composition product without toxic or side effect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for skin, in particular to a notoginseng converted saponin, an antifungal pharmaceutical composition thereof, a preparation method and application thereof. Background technique [0002] Dermatophytes are a group of pathogenic fungi, which invade human skin, hair and nails and other keratinous tissues to cause tinea corporis, athlete's foot or black nails. According to the statistics of the World Health Organization (WHO), 1 / 4 of the world's population is affected by dermatophytes, and a survey in southern my country found that the incidence of tinea pedis among the population is as high as 60%. Trichophyton rubrum, Trichophyton rubrum, and Trichophyton mentagrophytes are the main causes of athlete's foot, onychomycosis, tinea corporis, and jock itch. Pathogenic bacteria are mainly infected through contact with patients, and a few are infected by contact with soil. The indirect contact infection with...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K31/704A61K9/06A61K9/12A61K8/97A61K8/60A61Q19/00A61Q17/00A61P31/10A61P17/00A61K8/9789
CPCA61K8/602A61K8/97A61K9/0014A61K9/06A61K9/12A61K31/704A61K36/258A61K47/10A61K47/42A61K2236/51A61K2236/55A61K2800/10A61Q17/005A61Q19/00
Inventor 任贵兴薛鹏杨修仕么杨
Owner INST OF CROP SCI CHINESE ACAD OF AGRI SCI
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