A kind of injection for treating non-Hodgkin's lymphoma and preparation method thereof

A non-Hodgkin and injection technology, applied in the field of medicine, can solve the problems of long production cycle, complex prescription process, high equipment requirements, etc., and achieve the effect of easy operation, simple process and stable quality

Inactive Publication Date: 2018-05-25
QINGDAO TUMOR HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the liposome preparation of picantron maleate has the disadvantages of complex prescription process, long production cycle and high requirements for equipment

Method used

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  • A kind of injection for treating non-Hodgkin's lymphoma and preparation method thereof
  • A kind of injection for treating non-Hodgkin's lymphoma and preparation method thereof
  • A kind of injection for treating non-Hodgkin's lymphoma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] prescription

[0022]

[0023] Preparation Process

[0024] Weigh the prescription amount of poloxamer 188, benzyl benzoate and sodium citrate and dissolve them in an appropriate amount of water for injection, weigh the prescription amount of picantron maleate and dissolve them in the above solution, stir and mix evenly, and use Appropriate amount of pH regulator (0.1mol / L citric acid solution or 0.1mol / L sodium hydroxide solution) to adjust the pH value, dilute to the total volume with water for injection, stir and mix evenly, filter, fill, visual inspection That is the finished product.

Embodiment 2

[0026] prescription

[0027]

[0028] Preparation Process

[0029] Weigh the prescription amount of poloxamer 188, benzyl benzoate and sodium citrate and dissolve them in an appropriate amount of water for injection, weigh the prescription amount of picantron maleate and dissolve them in the above solution, stir and mix evenly, and use Appropriate amount of pH regulator (0.1mol / L citric acid solution or 0.1mol / L sodium hydroxide solution) to adjust the pH value, dilute to the total volume with water for injection, stir and mix evenly, filter, fill, visual inspection That is the finished product.

Embodiment 3

[0031] prescription

[0032]

[0033] Preparation Process

[0034] Weigh the prescription amount of poloxamer 188, benzyl benzoate and sodium citrate and dissolve them in an appropriate amount of water for injection, weigh the prescription amount of picantron maleate and dissolve them in the above solution, stir and mix evenly, and use Appropriate amount of pH regulator (0.1mol / L citric acid solution or 0.1mol / L sodium hydroxide solution) to adjust the pH value, dilute to the total volume with water for injection, stir and mix evenly, filter, fill, visual inspection That is the finished product.

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to an injection for treating NHL (non-hodgkin lymphoma) and a preparation method thereof. The injection for treating NHL is mainly prepared from active ingredients of maleic acid pixantrone, sodium chloride, dispersing agents, nzyl benzoate, sodium citrate, pH regulators and injection water. The injection for treating NHL has the advantages that the quality is stable; all indexes conform to the quality requirements; the process is simple; the operation is convenient.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an injection for treating non-Hodgkin's lymphoma and a preparation method thereof. Background technique [0002] Non-Hodgkin lymphoma (NHL) is a group of malignant tumors originating from lymph nodes and other lymphoid tissues, and is a major type of lymphoma. The worldwide incidence has reached 20 / 100,000. Surveillance epidemiology and end results (SEER) incidence data in the United States show that men are more susceptible to NHL than women. Non-Hodgkin B-cell lymphoma is the main type of NHL, accounting for about 85% of NHL. The average age at diagnosis of non-Hodgkin's B-cell lymphoma in the United States is 67 years. China's statistics show that non-Hodgkin's B-cell lymphoma can occur at any age, but it is more common in children and young adults. The morbidity and mortality in my country's coastal areas are higher than those in the inland areas, and those i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/473A61K47/34A61K47/12A61K47/14A61K47/26A61K47/44A61P35/00
CPCA61K9/0019A61K9/08A61K31/473A61K47/10A61K47/12A61K47/14A61K47/26A61K47/44
Inventor 宋霆婷
Owner QINGDAO TUMOR HOSPITAL
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