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Application of ginsenoside Ro in preparation of antitumor drugs

A technology of anti-tumor drugs and ginsenosides, applied in the directions of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., to achieve good inhibitory effect and enhanced inhibitory effect.

Inactive Publication Date: 2016-07-20
JIAN SHENGLIYUAN BIOTECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Shibata, S., Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. JKoreanMedSci, 2001.16 Suppl: S28-37], therefore, there is no report on the application of ginsenoside Ro as the main component in the preparation of anti-tumor drugs

Method used

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  • Application of ginsenoside Ro in preparation of antitumor drugs
  • Application of ginsenoside Ro in preparation of antitumor drugs
  • Application of ginsenoside Ro in preparation of antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0038] 1. Test material

[0039] 1.1 Drugs and reagents

[0040] DMEM high-glucose medium was purchased from Gibco Company, FBS fetal bovine serum was purchased from Clark Company, and trypsin was purchased from Beijing Suolaibao Biotechnology Co., Ltd.

[0041] 1.2 Cells and animals

[0042] Highly metastatic mouse melanoma cells B16F10 were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences. C57BL / 6 mice, male, 20-22 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0043] 1.3 Animal model

[0044] 1.3.1 Cell recovery: take out the cells frozen in liquid nitrogen, quickly place them in a 37°C water bath, melt them into a liquid state, place them in a clean bench after disinfection, and transfer the cell liquid to a 10ml centrifuge tube after blowing evenly , add 2ml of DMEM high-glucose medium, 1000rpm, centrifuge for 5min, take it out and discard the supernatant, add DMEM high-glucose medium containing 10% FBS ...

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Abstract

The invention mainly relates to application of ginsenoside Ro in the preparation of antitumor drugs. Experiments for studying on changes in the size of tumors of a mouse injected with ginsenoside Ro show that early inhibition rate for the growth of tumors in the mouse injected with the ginsenoside Ro is substantially unchanged and the tumors enlarge synchronously with tumors in model group animals; after entering logarithmic growth stage, the ginsenoside Ro has enhanced inhibitory action on the enlargement of the tumors, and the inhibition rate is significantly higher than the tumor growth inhibitory action in slow growth stage; it is proved that the ginsenoside Ro has good inhibitory action on mouse melanoma. According to tests for researching change of tumor weight of the mouse injected with the ginsenoside Ro, the ginsenoside Ro has good inhibitory action on the melanoma and can be prepared into new antitumor drugs.

Description

technical field [0001] The present invention relates to the application of ginsenoside Ro, in particular to the application of ginsenoside Ro in the preparation of anti-melanoma drugs. Background technique [0002] Malignant tumor, that is, cancer, is a common and frequently-occurring disease caused by the infinite proliferation of endogenous cells, which seriously threatens human health. It is one of the three major diseases that cause human death. At present, the treatment of cancer mainly There are surgery, radiation therapy, and chemotherapy, among others. Chemotherapy is a treatment method that uses chemical drugs to block the mechanism of cell division to inhibit the growth and reproduction of cancer cells and promote the differentiation of cancer cells. It is also the main method for the treatment of malignant tumors. However, traditional chemotherapy drugs have a series of limitations in the treatment of cancer. For example, common chemotherapy drugs such as cispla...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P35/00A61P35/02A61P7/00
CPCA61K31/704
Inventor 肖禹安张楠淇
Owner JIAN SHENGLIYUAN BIOTECH DEV CO LTD
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