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Method for making burn animal model

An animal model and animal technology, applied in the field of medical and life science experimental research, can solve the problems of the area and degree of burns that are difficult to control, the animal suffers greatly, and the repeatability and accuracy are poor.

Pending Publication Date: 2016-08-03
BEIJING UNION GENIUS PHARMA TECH
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  • Claims
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AI Technical Summary

Problems solved by technology

Methods such as electric heating and radiation are extremely dangerous, and improper operation may cause burns to the operator. Methods such as mechanical damage (shearing, abrasion) are quite different from clinical manifestations, and most of the existing burn models are aimed at A certain degree of damage (such as deep II°) damage, and the area and degree of burns are difficult to control, and the repeatability and accuracy under different experimental conditions are poor, which brings certain benefits to the research of burn mechanism research and the research of therapeutic drugs and methods. limitations
In addition, the existing burn model production process brings great pain to animals, which does not conform to the principle of animal welfare

Method used

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  • Method for making burn animal model
  • Method for making burn animal model
  • Method for making burn animal model

Examples

Experimental program
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Effect test

Embodiment 1

[0008] Example 1: Fix the irradiation distance and output power, and change the influence of irradiation time on the degree of damage

[0009] Wistar rats were anesthetized with pentobarbital sodium and their back hair was shaved to form a hairless area of ​​about 4 × 6 cm. The hairless area was divided into 6 areas, each area was about 2 × 2 cm, and marked with a marker pen. From top to bottom, from left to right, they are respectively marked as ①②③④⑤⑥, see attached figure 1 . Use PDT-670 laser (manufactured by Guilin Xingda Photoelectric Medical Instrument Co., Ltd.), adjust the output power to 2000mW, adjust the distance between the fiber optic head and the central part of No. The time is 45s, click the start button to start the irradiation, and the laser will automatically turn off after the irradiation is completed. According to the above method, the output power is fixed at 2000mW, the irradiation distance is 2cm, and the irradiation time is adjusted to 90s, 120s, 240s...

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Abstract

The invention relates to a method for producing burn animal models with laser, which is characterized in that the laser is used to directly irradiate hairless or depilated animal skin, and the burns of I~IV° can be reproduced by adjusting the output power, irradiation time and irradiation distance. This model is easy to operate, the degree of burn can be precisely controlled, the success rate is high, the reproducibility is good, and the safety is high. It causes less pain to animals and conforms to the principles of animal welfare. Screening, drug efficacy evaluation, mechanism of action research, etc.

Description

technical field [0001] The invention relates to a method for producing a burn animal model by laser, which is suitable for the research on the pathological mechanism of the burn, the screening of the burn drug, the evaluation of the curative effect, the research on the mechanism of action and the like. The invention belongs to the field of medical and life science experiment research. Background technique [0002] Burn refers to the damage of skin, mucous membrane and even subcutaneous tissue caused by heat, chemical, electricity, radiation, laser and other factors. The emergency room receives a large number of burn patients every year. Mild burns often have insufficient attention, and scars are left due to untimely treatment. Moderate and severe burns are prone to infection, difficult to heal, and the treatment cycle is long. The pathological mechanism of burns is complex, and there is a lack of effective animal models for the verification of therapeutic drugs and methods....

Claims

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Application Information

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IPC IPC(8): A61D1/00A61B18/20
Inventor 刘汉清王爱平魏金峰靳洪涛郭新苗张倩倩林妮阎晓丹李烨冯婧怡刘天天秦丹张飘飘
Owner BEIJING UNION GENIUS PHARMA TECH
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