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Pharmaceutical composition for thyroid cancer osseous metastasis and osteoporosis

A technology for osteoporosis and thyroid cancer, applied in the field of traditional Chinese medicine, to achieve good patient tolerance, promote bone reconstruction, and less side effects

Inactive Publication Date: 2016-08-31
QINGDAO CHENDA BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few traditional Chinese medicine preparations on the market for patients with bone metastasis of thyroid cancer and osteoporosis.

Method used

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  • Pharmaceutical composition for thyroid cancer osseous metastasis and osteoporosis
  • Pharmaceutical composition for thyroid cancer osseous metastasis and osteoporosis
  • Pharmaceutical composition for thyroid cancer osseous metastasis and osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 capsule

[0038] Prescription: 30 parts of Duanjieshen, 13 parts of Rehmannia glutinosa, 18 parts of Kunming Begonia, 10 parts of Dabaiyao, 12 parts of Sangjisheng, 16 parts of Niu Ma Teng, 12 parts of Kidney Classic Grass, 15 parts of Qingfeng Teng, 8 parts of Xia Wu, 12 servings of snake berries.

[0039] Preparation method: (1) Take Kunming Shanhaitang, Dabaiyao, Qingfengteng, and Xiawu according to the prescription, add 4 times the amount of 65% ethanol after crushing, reflux extraction twice, each time for 1 to 3 hours, filter, and combine the two filtrates , collecting the filter residue after extracting Kunming Shanhaitang, Dabaiyao, Qingfengteng, and summer without ethanol, recovering ethanol from the filtrate until it has no alcohol smell, continuing to concentrate under reduced pressure to form a dry extract, freeze-drying, and pulverizing to obtain an ethanol extract;

[0040] (2) Combine Kunming Mountain Begonia, Dabaiyao, Qingfengteng, and sum...

Embodiment 2

[0042] Embodiment 2 capsules

[0043] Prescription: 35 parts of Duanjieshen, 15 parts of Rehmannia glutinosa, 18 parts of Kunming Begonia, 12 parts of Dabaiyao, 15 parts of Sangjisheng, 15 parts of Niu Ma Teng, 15 parts of Kidney Classic Grass, 12 parts of Qingfeng Teng, 10 parts of Xia Wu, 10 servings of snakeberry.

[0044] Preparation method: (1) According to the prescription, take Kunming Shanhaitang, Dabaiyao, Qingfengteng, and summer without crushing, add 5 times the amount of 62% ethanol, reflux extraction twice, each time for 1.5-2.0 hours, filter, and combine the two filtrates , collecting the filter residue after extracting Kunming Shanhaitang, Dabaiyao, Qingfengteng, and summer without ethanol, recovering ethanol from the filtrate until it has no alcohol smell, continuing to concentrate under reduced pressure to form a dry extract, freeze-drying, and pulverizing to obtain an ethanol extract;

[0045] (2) Combine Kunming Mountain Begonia, Dabaiyao, Qingfengteng, and...

Embodiment 3

[0047] Embodiment 3 capsules

[0048] Prescription: 32 parts of Duanjieginseng, 15 parts of Rehmannia glutinosa, 15 parts of Kunming Shanhaitang, 12 parts of Dabaiyao, 10 parts of Sangjisheng, 18 parts of Niu Ma Teng, 15 parts of Kidney Classic Grass, 10 parts of Qingfeng Teng, 8 parts of Xia Wu, 8 servings of snakeberry.

[0049] Preparation method: (1) Take Kunming Mountain Begonia, Dabaiyao, Qingfengteng, and Xia Wu according to the prescription, add 7 times the amount of 60% ethanol after crushing, reflux extraction twice, each time for 1 to 3 hours, filter, and combine the two filtrates , collecting the filter residue after extracting Kunming Shanhaitang, Dabaiyao, Qingfengteng, and summer without ethanol, recovering ethanol from the filtrate until it has no alcohol smell, continuing to concentrate under reduced pressure to form a dry extract, freeze-drying, and pulverizing to obtain an ethanol extract;

[0050] (2) Combine Kunming Mountain Begonia, Dabaiyao, Qingfengten...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for thyroid cancer osseous metastasis and osteoporosis and a preparation method thereof. The pharmaceutical composition is carefully prepared from medicinal raw materials of roots of wallich swallowwort, prepared rehmannia roots, roots of tripterygium hypoglaucum (Devl.) Hutch., griffith condorvine herb, herba taxilli, evergreen mucuna roots and leaves, tubers of habenaria ciliolaris kranz1, stem leaves or roots of sabia japonica Maxim., rhizomes of decumbent corydalis and Indian strawberries according to a weight proportion. Compatibility of the formula is achieved, the effects of tonifying the kidney, strengthening bones, clearing and activating the channels and collaterals, clearing heat, removing toxicity, dissipating blood stasis and stopping pain are achieved, and the pharmaceutical composition can adjust the physiological function of an organism, improve the immunity, improve the life quality of a patient, improve blood circulation of nidi, increase bone mineral density, relieve bone destruction, reduce bone pain and relieve toxic and side effects of radiotherapy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for thyroid cancer bone metastasis with osteoporosis and a preparation method thereof. Background technique [0002] Thyroid cancer is a common malignant tumor in the head and neck, accounting for 1% to 2% of systemic malignant tumors. It is more common in women and can be seen in any age group. At present, the incidence of thyroid cancer shows a significant upward trend year by year. Differentiated thyroid cancer is the most common pathological type of thyroid cancer, accounting for up to 90%. Differentiated thyroid cancer (DTC) usually develops slowly and has a low degree of malignancy. Therefore, when thyroid cancer is diagnosed clinically, most patients have metastasized to varying degrees. The most common metastatic site of DTC is bone. Tumors destroy the balance between osteoblasts and osteoclasts, leading to the dissolu...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P35/04A61P19/10
CPCA61K36/185A61K36/27A61K36/486A61K36/66A61K36/73A61K36/804A61K36/898A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 陈令浩
Owner QINGDAO CHENDA BIOLOGICAL SCI & TECH
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