Pharmaceutical composition for treating primary trigeminal neuralgia with syndrome of stomach fire uprush

A trigeminal neuralgia, primary technology, applied in the field of traditional Chinese medicine, can solve problems such as damage to cranial nerves or brain tissue, high treatment costs, leukopenia, etc., to achieve no toxic side effects, satisfactory clinical treatment effect, rigorous prescription Effect

Inactive Publication Date: 2016-09-21
陈红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Not only the treatment time is long, but the treatment cost is also relatively high; some may even cause damage to cranial nerves or brain tissue, and there are also serious sequelae such as blindness, cerebral hemorrhage, and facial paralysis.
The side effects of western medicine are relatively obvious. Some patients have dizziness, fatigue, nausea and vomiting, leukopenia, rash and other adverse reactions after use.

Method used

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  • Pharmaceutical composition for treating primary trigeminal neuralgia with syndrome of stomach fire uprush
  • Pharmaceutical composition for treating primary trigeminal neuralgia with syndrome of stomach fire uprush
  • Pharmaceutical composition for treating primary trigeminal neuralgia with syndrome of stomach fire uprush

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Drugs for oral administration - preparation of capsules

[0040] Prescription: 5 parts of gypsum, 10 parts of coptis, 15 parts of Dibacao, 10 parts of fennel, 8 parts of Citrus aurantium, 12 parts of rehmannia, 15 parts of scull, 10 parts of Chuanxiong, and 10 parts of white silkworm.

[0041] Preparation method: take Coptis chinensis, Dibacao, water fennel, aurantium aurantium, raw rehmannia glutinosa, scorpion scorpion, Chuanxiong, and white silkworm, and grind them into coarse powder, add water to soak for 3-4 hours, decoct and extract twice, each time 1.0- 2.0 hours (start timing from boiling), combine filtrate, add ethanol to make solution alcohol content be 40%, leave standstill after 12 hours, discard lower sediment, obtain supernatant, dry after concentrating under reduced pressure, and gypsum pole Mix the fine powder evenly, put it into the capsule shell, and get it. The amount of each capsule is 0.35g, which is equivalent to containing 0.9g of crude drug.

[...

Embodiment 2

[0046] Drugs for oral administration - preparation of capsules

[0047] Prescription: 5 parts of gypsum, 8 parts of coptis, 14 parts of Dibacao, 12 parts of fennel, 5 parts of Citrus aurantium, 10 parts of rehmannia, 12 parts of scull, 7 parts of Chuanxiong, and 8 parts of white silkworm.

[0048] Preparation method: carry out with reference to the operation of the capsule of Example 1.

[0049] Medicine for external use - preparation of gel

[0050] Prescription: 25 parts of horseshoe fern, 8 parts of Chuanshiteng, 14 parts of Toguxiang, 6 parts of Asarum.

[0051] Preparation method: take calla fern, chrysanthemum chrysanthemum, chrysanthemum, and asarum and grind them into particles with an average particle size of 30-80 μm, add 3-7 times the amount of 50% ethanol aqueous solution, and use ultrasonic extraction. The extraction conditions include: The ultrasonic power is 150-160W, the extraction temperature is 35-40°C, and the extraction time is 20-40min; after the ultraso...

Embodiment 3

[0053] Drugs for oral administration - preparation of capsules

[0054] Prescription: 6 parts of gypsum, 8 parts of coptis, 13 parts of Dibacao, 12 parts of fennel, 6 parts of Citrus aurantii, 12 parts of rehmannia, 10 parts of scull, 9 parts of Chuanxiong, and 7 parts of silkworm.

[0055] Preparation method: carry out with reference to the operation of the capsule of Example 1.

[0056] Medicine for external use - preparation of gel

[0057] Prescription: 20 parts of horseshoe fern, 6 parts of Chuanshiteng, 12 parts of Toguxiang, and 8 parts of Asarum.

[0058] Preparation method: carry out with reference to the operation of the gel agent in Example 1.

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Abstract

The invention discloses a pharmaceutical composition for treating primary trigeminal neuralgia with the syndrome of stomach fire uprush and a preparation method of the pharmaceutical composition. The pharmaceutical composition includes a medicine for oral administration and a medicine for external application, wherein the medicine for oral administration is prepared from the following medicinal raw materials: gypsum, radix coptis, climbing violet herb, all-grass of winkled marshweed, fructus aurantii, radix rehmanniae, thatch screwpine fruits, rhizoma ligustici wallichii and bombyx batryticatus; and the medicine for external application is prepared from the following medicinal raw materials: rhizome of fokien angiopteris, aristolochia impressinervis C.F.Liang, radix gaultheriae and herba asari. On one aspect, the medicine for oral administration has functions of clearing and purging heat and activating meridians to stop pain, and the medicine for oral administration is capable of conditioning functions of internal organs, avoiding generation of phlegm and dampness, regulating spleen and stomach qi activities, depressing qi and eliminating fire so as to achieve an effect on relieving pain; on the other aspect, the medicine for external application can be directly applied to acupuncture points and meridians and the efficacy of the medicine for external application spreads so as to relieve stagnation and shrinkage of local meridians caused by exogenous evil; the medicine for oral administration, on the basis of the physiological characteristics of penetration, moistening and perfusion and slow circulation of blood and qi, can achieve effects on rapidly alleviating pain and relieving pain; and the pharmaceutical composition, through the combination of the medicine for oral administration and the medicine for external application, can be used for treating stomach fire and facial pain; and the pharmaceutical composition is easier to achieve a satisfying clinical treatment effect and is free from toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating primary trigeminal neuralgia of stomach-fire ascending rush type and a preparation method thereof. Background technique [0002] Primary trigeminal neuralgia is sudden and paroxysmal acupuncture-like severe pain in the distribution area of ​​the trigeminal nerve, which is unbearable, mostly on one side, and more common in the second and third branches. Pain may be accompanied by facial muscle twitching, flushing, conjunctival hyperemia, and tearing; the attack only lasts for a few seconds and 1-2 minutes; after the attack, everything is as usual; there are often obvious attack triggers such as brushing teeth, eating, talking, etc.; there are often triggers on the face Point (trigger point), often caused by touching a sensitive point. Trigger points are often located on the forehead, nasal side of the upper lip, and low...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K36/45A61P25/02A61K35/64A61K33/06
CPCA61K33/06A61K9/06A61K9/4841A61K35/63A61K36/02A61K36/11A61K36/236A61K36/264A61K36/268A61K36/45A61K36/718A61K36/752A61K36/804A61K36/86A61K36/88A61K47/32A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 陈红
Owner 陈红
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