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CS/beta-TCP (calcium silicate/beta-tricalcium phosphate) porous composite material for promoting osteogenesis and vasculogenesis and preparation method thereof

A porous composite material and angiogenesis technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problem of no osteoinductive and angiogenic effects, no uniform through-hole structure, and unsatisfactory effects of osteoconduction and osseointegration etc. to achieve the effect of reducing bone resorption and increasing the specific surface area

Inactive Publication Date: 2016-10-12
SHANGHAI JIAO TONG UNIV
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

HA will not degrade in the body, TCP has no osteoinductive and angiogenic effects, and there is no uniform through-hole structure inside the block, so the effects of osteoconduction and osseointegration are not ideal

Method used

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  • CS/beta-TCP (calcium silicate/beta-tricalcium phosphate) porous composite material for promoting osteogenesis and vasculogenesis and preparation method thereof
  • CS/beta-TCP (calcium silicate/beta-tricalcium phosphate) porous composite material for promoting osteogenesis and vasculogenesis and preparation method thereof
  • CS/beta-TCP (calcium silicate/beta-tricalcium phosphate) porous composite material for promoting osteogenesis and vasculogenesis and preparation method thereof

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Experimental program
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Embodiment 1

[0029] This embodiment relates to a block scaffold material for promoting osteogenesis, which is made of CS / β‐TCP composite material, and the cross section of the channel is a square of 350 μm×350 μm.

[0030] Such as figure 1 As shown, this embodiment includes the following steps:

[0031] Step 1. Weigh 5g of calcium silicate powder and β‐tricalcium phosphate powder according to the mass ratio of calcium silicate accounting for 0%, 5%, and 10% of the total powder, and sieve and mix them in two 50mL centrifuge tubes , add 0.3g PVA one by one and mix evenly to form a paste, and put it into the barrel of the 3D bio-plotter printer.

[0032] The calcium silicate powder is self-made in the laboratory. Stir and mix sodium silicate and calcium nitrate at a molar ratio of 1:1 overnight, then filter the suspension, wash the precipitate with deionized water for 3 times, and wash with absolute ethanol for 2 After the first time, dry overnight under vacuum; calcined at 800°C for 2 hour...

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Abstract

A CS / β‐TCP porous composite material for promoting osteogenesis and its preparation method, by mixing calcium silicate (CS) and tricalcium phosphate (β‐TCP) powders according to the mass ratio, adding polyvinyl alcohol ( PVA) is uniformly mixed into a paste, and then 3D printed, and the printed three-dimensional model is dried at room temperature and then sintered at high temperature to obtain a CS / β-TCP porous composite material with a pore cross-section of a square of 350 μm×350 μm; the process of the present invention is simple , with better biocompatibility and uniform through-hole structure, which is beneficial to osteoinduction and angiogenesis.

Description

technical field [0001] The present invention relates to a technology in the field of biomedical materials for repairing bone tissue, in particular to a CS / β-TCP (Calcium Silicate / β-Tricalcium Phosphate, calcium silicate / β-tricalcium phosphate) for promoting osteogenesis Calcium) porous composite material and its preparation method. Background technique [0002] There are tens of millions of patients with bone defect or osteonecrosis caused by trauma, tumor resection, chronic osteomyelitis, and vascular necrosis every year in the world. There is an urgent need for a large number of suitable bone graft materials in clinical practice. At present, the main methods for clinical treatment of bone defects are: autologous bone graft, allogeneic bone graft, and filling with artificial biomaterials. Among them, autologous bone grafting is the current gold standard, but its source is limited, it cannot fill large bone defects, and it will cause secondary injury to the patient, prolong...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/02A61L27/56A61L27/50
CPCA61L27/12A61L27/025A61L27/50A61L27/56A61L2430/02
Inventor 邓源江川李翠笛李涛王金武戴尅戎
Owner SHANGHAI JIAO TONG UNIV
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