Composition with blood fat and blood sugar reducing activity and preparing method and application of composition

A composition and blood sugar-lowering technology, applied to a composition of Chinese medicinal substances with blood lipid-lowering and blood-sugar-lowering activities and its preparation, field of traditional Chinese medicine medicinal substances

Inactive Publication Date: 2016-11-23
石任兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, market drugs are mainly chemi

Method used

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  • Composition with blood fat and blood sugar reducing activity and preparing method and application of composition
  • Composition with blood fat and blood sugar reducing activity and preparing method and application of composition
  • Composition with blood fat and blood sugar reducing activity and preparing method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0023] Experimental example 1 hypolipidemic effect of the present invention

[0024] (1) Experimental materials

[0025] 1. Experimental animals

[0026] Kunming mice, half male and half female, weighing 18-22g. Provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0027] 2. Drugs and reagents

[0028] Test drug: the composition of the traditional Chinese medicine drug substance (referred to as the composition). Reagents: Simvastatin Tablets (Lot No.: L026625), Hangzhou Merck Pharmaceutical Co., Ltd.; Normal Saline (Lot No.: C13040602), Shandong Hualu Pharmaceutical Co., Ltd.; Mouse Triglyceride Enzyme Kit (Product No.: E03T0018), Bluegene Mouse Total Cholesterol Kit (Cat. No.: E03C0745), Bluegene Company; Mouse Low-Density Lipoprotein Enzyme-Linked Kit (Cat. No.: E03L0020), Bluegene Company; Mouse High-Density Lipoprotein Enzyme-Linked Kit (Cat. No.: E03H0211), Bluegene company.

[0029] (2) Experimental methods and results

[0030] 1. Grouping a...

experiment example 2

[0043] Experimental example 2 hypoglycemic effect of the present invention

[0044] (1) Experimental materials

[0045] 1. Experimental animals

[0046] ICR mice, half male and half female, weighing 18-22g. Provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0047] 3. Drugs and reagents

[0048]Test drug: composition. Reagents: alloxan (batch number: 2041558501; sigma-aldrich Sigma Aldrich (Shanghai) Trading Co., Ltd.); metformin hydrochloride tablets (batch number 1409054; China Resources Double Crane Pharmaceutical Co., Ltd.); normal saline (batch number: C13040602, Shandong Hualu Pharmaceutical Co., Ltd.).

[0049] (2) Experimental methods and results

[0050] 1. Grouping and administration

[0051] After one week of adaptive feeding, the mice were divided into 4 groups, with 8 mice in each group, half male and half female, namely the blank group, model group, positive drug group, and composition test group; the blank group and model group we...

Embodiment 1

[0063] Embodiment 1: Capsules

[0064] Stevia 300g Lotus Leaf 300g

[0065] Hawthorn 200g Sanqi 100g

[0066] Take 0.9 kg of raw material medicine decoction pieces according to the above ratio, reflux extraction with 10 times the amount of 70% ethanol for 3 times, each extraction for 3 hours, and recover the solvent under reduced pressure to obtain the extract, add water to disperse and dissolve, so that the concentration of the aqueous solution is 0.08g / mL, and the aqueous solution Through weakly polar or non-polar macroporous adsorption resin, the adsorption flow rate is 3.5BV / h, the resin column diameter-to-height ratio is 1:8, and the sample solution concentration is 0.09g / mL. Collect the sample effluent and wash with water. Remove 4BV, the elution flow rate is 6BV / h, collect the eluate, combine the sample effluent and water eluate, recover the solvent, and dry under reduced pressure to obtain the enrichment I; 20% ethanol elutes 3BV, elutes The flow rate is 3.5BV / h, col...

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Abstract

The invention belongs to the field of Chinese herbal medicine substance activity and medicine research and development thereof and relates to a Chinese herbal medicine substance, in particular to a composition which has blood fat and blood sugar reducing activity and is prepared from Chinese herbal medicine substances, a preparing method and application of the composition, and an associated Chinese herbal or natural medicine compound (such as a Chinese herbal compound prepared from stevia rebaudiana, lotus leaves, panax notoginseng, hawthorn fruits and the like). The chemical architecture of the Chinese herbal medicine substance composition is mainly prepared from phenols, alkaloids, terpenes, amino acids and the like, and can be obtained through solvent (such as diluted alcohol) extraction from the compound or separation and enrichment of macroporous resin; tests with a hyperlipidemia model and a diabetes model of mice proves that the composition prepared from the Chinese herbal medicine substances has remarkable blood fat and blood sugar reducing activity. The composition prepared from the Chinese herbal medicine substances and the associated compound of the composition can be used for medicine and health products.

Description

technical field [0001] The invention belongs to the field of research and development of active substances and their products, and relates to a traditional Chinese medicine substance, in particular to a composition of a traditional Chinese medicine substance with hypolipidemic and blood sugar-lowering activities, a preparation method and an application thereof. Background technique [0002] Hyperlipidemia refers to high blood lipid levels, which can directly cause some diseases that seriously endanger human health, such as atherosclerosis, coronary heart disease, pancreatitis, etc., including primary and secondary types. Most drugs currently on the market have certain side effects while treating hyperlipidemia; diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tiss...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61P3/06A61P3/10A23L33/105
CPCA61K36/28A23V2002/00A61K36/258A61K36/62A61K36/734A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61K2300/00A23V2200/3262A23V2200/328A23V2250/21
Inventor 石任兵孙道涵姜艳艳赵博申立峰刘璐杨元陈唯
Owner 石任兵
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