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Manufacturing method of chemical using continuous fermentation

A manufacturing method and technology of chemicals, applied in the direction of fermentation, biofuel, etc., can solve the problems of removing and discarding further costs, separation of lactic acid, complicated refining process, and generation of gypsum, etc.

Active Publication Date: 2019-10-25
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, if the culture solution is neutralized with an alkaline substance such as calcium hydroxide, depending on the amount of the added alkaline substance, acid such as sulfuric acid added to dissociate lactate may Due to the influence of substances, by-products such as gypsum may be generated, which complicates the separation and purification of lactic acid and causes high production costs.
That is, when using a neutralizing agent, in addition to the raw materials of the neutralizing agent itself, the removal and disposal of unnecessary by-products such as gypsum require further costs.

Method used

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  • Manufacturing method of chemical using continuous fermentation
  • Manufacturing method of chemical using continuous fermentation
  • Manufacturing method of chemical using continuous fermentation

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Experimental program
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Embodiment

[0116] Hereinafter, the present invention will be described concretely with reference to examples. However, the present invention is not limited thereto.

reference example 1

[0117] (Reference example 1) Analysis method of glucose and ethanol

[0118] The concentrations of glucose and ethanol in the culture solution were quantified by comparison with standard samples under the HPLC conditions shown below.

[0119] Column: Shodex SH1011 (manufactured by Showa Denko Co., Ltd.)

[0120] Mobile phase: 5mM sulfuric acid (flow rate 0.6mL / min)

[0121] Reaction solution: no

[0122] Detection method: RI (differential refractive index)

[0123] Temperature: 65°C.

reference example 2

[0124] (Reference example 2) Analysis method of lactic acid

[0125] Lactic acid in the fermentation broth was quantified by comparison with a standard product under the HPLC conditions shown below.

[0126] Column: Shim-Pack SPR-H (manufactured by Shimadzu Corporation)

[0127] Mobile phase: 5mM p-toluenesulfonic acid (flow rate 0.8mL / min)

[0128] Reaction solution: 5mM p-toluenesulfonic acid, 20mM bis tris, 0.1mM EDTA·2Na (flow rate 0.8mL / min)

[0129] Detection method: conductivity

[0130] Temperature: 45°C.

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Abstract

The present invention is a method for producing chemicals by continuous fermentation using a separation membrane at a pH of 3.5 or less. By using yeast resistant to vanillin, chemicals can be produced efficiently without leaving a large amount of fermentation raw materials.

Description

technical field [0001] The present invention relates to a process for the manufacture of chemicals utilizing continuous fermentation at low pH conditions. Background technique [0002] Biomass-derived chemicals represented by biodegradable polymer raw materials such as lactic acid, and biofuels such as ethanol, as the emission of carbon dioxide into the atmosphere and the emergence of energy problems, as sustainability (sustainability) and life cycle assessment (LCA) corresponding products have received strong attention. [0003] In the case of producing organic acids such as lactic acid by microorganisms, the reduction in the pH of the culture solution caused by the produced organic acid causes a decrease in the productivity of the target organic acid, so it is necessary to lower the pH of the culture solution by a neutralizer. Keep it constant. For example, Patent Document 1 discloses a method for producing lactic acid by culturing yeast. In order to maintain the lactic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P7/06C12P7/40
CPCC12P7/06Y02E50/10C12P7/16C12P7/18C12P7/46C12P7/48C12P7/50C12P7/56
Inventor 小林宏治泽井健司山田胜成
Owner TORAY IND INC