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Traditional Chinese medicine combination for treating biliary calculus and preparation method of combination

A composition and gallstone technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as poor effect, mixed good and bad, poor effect of dissolving and removing stones, and achieve remarkable effect, prevent Calculus recurrence and low cost effect

Inactive Publication Date: 2016-11-30
青岛友诚高新技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lithotripsy is only suitable for patients with small gallbladder stones and good gallbladder function, and the Chinese patent medicines currently on the market for treating gallstones are mixed, and the effect of dissolving stones and removing stones is poor. The effect is not good, so the development of an effective treatment for gallstones is imperative

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) A kind of Chinese medicine for the treatment of gallstones, which is formed by the proportioning of the following raw materials by weight:

[0034] 30 parts of chicken gizzard, 25 parts of gallinaceous gold, 20 parts of Yuanhu, 15 parts of cardamom shell, 15 parts of radish, 10 parts of camphor, 10 parts of chicken feet, 10 parts of white flower gentian, 10 parts of mimosa, White Uncaria 5 parts, Astragalus 5 parts.

[0035] (2) Preparation method:

[0036] In the first step, Gallinarum and Yuanhu are mixed in proportion, extracted twice with n-propanol having an alcohol concentration of 70% equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, and then Purify 1-2 times with ethanol, combine the extracts, recover ethanol under reduced pressure and concentrate to a paste with a relative density of 1.21-1.24 at 60°C, dry and pulverize into powder;

[0037] The second step i...

Embodiment 2

[0041] (1) a kind of Chinese medicine for the treatment of gallstones is formed by the proportioning of following raw materials by weight: same as embodiment 1.

[0042] (2) Preparation method:

[0043] In the first step, Gallinarum and Yuanhu are mixed in proportion, extracted twice with n-propanol having an alcohol concentration of 70% equivalent to twice the mass of the mixture, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, and then Purify once with ethanol, combine the extracts, recover ethanol under reduced pressure and concentrate to a paste with a relative density of 1.21-1.24 at 60°C, dry and pulverize into powder;

[0044] In the second step, the cardamom shell, radish, camphor, and chicken feet are extracted twice with n-propanol with an alcohol concentration of 80%, and the extracts are combined, concentrated under reduced pressure, dried, and pulverized into powder. The powder was dissolved in water that was...

Embodiment 3

[0048] 1. Long-term toxicity test process:

[0049] Apply Wistar rats (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. provides) experimental medicine is set to high, medium and low three dosages, be respectively the capsule 8g / kg, 4g / kg, 2g of embodiment 1 formula / kg. Calculated according to the human dose of 0.1g / kg / day tablet, it is 80 times, 40 times and 20 times of the effective dose for human respectively; another control group is set up, which is given continuously for 90 days and 180 days by intragastric administration and part of the animals are withdrawn for 10 days. Days later, the effects on various physiological and biochemical indicators of rats were observed. The experimental results show that: continuous oral administration of different doses to rats for 180 days has no effect on the food intake and weight growth of the rats. No significant toxic effects were found on liver and kidney function. There was no obvious effect on blood routine, bl...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine combination for treating biliary calculus and a preparation method of the traditional Chinese medicine combination. The traditional Chinese medicine combination comprises wight parnassia herb, endothelium corneum gigeriae galli, rhizoma corydalis, round cardamom shell, radish sprouts, litsea rotundifolia, curled paralysis, gentiana purdomii marq, sensitive plants, uncaria sessilifructus and astragalus. The invention further discloses a preparation method of the traditional Chinese medicine combination. The traditional Chinese medicine combination has the advantages of good curative effect, low cost, high curative ratio, free adverse reaction and the like in the aspect treating the biliary calculus. The traditional Chinese medicine combination can comprehensively reconcile functions of five organs, improve urinary calculus removing capacity of a body, effectively prevent stasis accumulation in the body and calculus recurrence, promote blood circulation, remove blood stasis, regulate qi and remove dampness and is remarkable in effect.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a traditional Chinese medicine composition for treating gallstones and a preparation method thereof. Background technique [0002] Gallstone is clinical common disease, frequently-occurring disease, and gallstone patient is increasing year by year especially in recent years. At present, the commonly used clinical programs for the treatment of gallstones include Western medicine surgery, lithotripsy, and oral treatment with Chinese patent medicines. One of the disadvantages of surgical treatment of gallstones is the residual and recurrence of postoperative stones. Lithotripsy is only suitable for patients with small gallbladder stones and good gallbladder function, and the Chinese patent medicines currently on the market for treating gallstones are mixed, and the effect of dissolving stones and removing stones is poor. The effect is not good, so it is imperative to develop an effective t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P1/16A61K35/57
CPCA61K36/185A61K35/57A61K36/31A61K36/48A61K36/481A61K36/515A61K36/54A61K36/66A61K36/74A61K36/9064A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 不公告发明人
Owner 青岛友诚高新技术有限公司
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