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Medicinal composition as well as preparation method, preparation and application thereof

A technology of composition and medicine, applied in the field of pharmaceutical composition and its preparation

Inactive Publication Date: 2016-12-07
CHUXIONG MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Related drugs currently on the market can not fully meet the market demand, therefore, it is very necessary to develop a drug that clears and moistens the throat

Method used

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  • Medicinal composition as well as preparation method, preparation and application thereof
  • Medicinal composition as well as preparation method, preparation and application thereof
  • Medicinal composition as well as preparation method, preparation and application thereof

Examples

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preparation example Construction

[0025] The preparation method of the pharmaceutical composition of the present invention includes the steps of pretreatment and extraction, and specifically includes:

[0026] A. Pre-treatment: Weigh the root of the white thorn, the water golden phoenix, the kung fu wood and the blood man grass according to the formula ratio, pulverize, sieve and mix to obtain the material a for later use;

[0027] B. Extraction: add the ethanol solution of 8-12 times the weight of the material a to the material a and extract to obtain the target drug composition.

[0028] In step A, pulverizing and sieving is to pulverize and pass through a 20-100 mesh sieve.

[0029] The extraction described in step B is percolation extraction, reflux extraction, decoction extraction or ultrasonic extraction.

[0030] The described percolation extraction is to add 8 to 12 times the weight of material a into material a with 30 to 70% ethanol solution in volume percentage for 2 to 4 hours, perform percolation...

Embodiment 1

[0051] Weigh 4125g of Nitraria flower root, 3685g of Gongluomu, 3300g of Shuijinfeng, 2530g of Xuemancao, and 13640g of decoction pieces of four herbs, crush them into coarse powder, and mix well. For the first time, add 10 times the amount of 70% ethanol and soak for 2 hours. Before reflux, make up the amount of ethanol according to the water absorption rate. According to the water absorption rate experiment, the amount of ethanol to make up is 1.63 times the amount of medicinal materials. Add 8 times the amount of reflux for 1 hour, filter, combine the three filtrates, and concentrate to a relative density of 1.05. Add chitosan in an amount of 0.2‰ for clarification, keep warm at 30°C for 1 hour, let stand below 10°C for more than 8 hours, absorb the supernatant and filter, concentrate the filtrate under reduced pressure to obtain a liquid extract, and dry to obtain a dry extract, which is the target drug combination thing.

Embodiment 2

[0053] Weigh 3375g of Nitraria flower root, 3015g of Gongluomu, 2700g of Shuijinfeng, 2070g of Xuemancao, and 11160g of decoction pieces of four herbs, crush them into coarse powder, and mix well. For the first time, add 12 times the amount of 70% ethanol and soak for 4 hours. Before reflux, make up the amount of ethanol according to the water absorption rate. According to the water absorption rate experiment, the amount of ethanol to be added is 1.63 times the amount of medicinal materials. The reflux temperature is controlled at 90°C. For 1.5 hours, add 9 times the amount for the second and third times to reflux for 1 hour, filter, combine the three filtrates, and concentrate to a relative density of 1.10. Add 0.3% diatomaceous earth for clarification, keep warm at 50°C for 1 hour, let stand below 10°C for more than 12 hours, absorb the supernatant and filter, concentrate the filtrate under reduced pressure to obtain a liquid extract, and dry to obtain a dry extract, which is...

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Abstract

The invention discloses a medicinal composition and a preparation method thereof, a preparation and application thereof. The medicinal composition is prepared from the following raw materials in percentage by weight: 0.1 to 99 percent of sophora viciifolia root, 0.1 to 99 percent of whole grass and root of impatiens noli-tangere L., 0.1 to 99 percent of leatherleaf mahonia stem and 0.1 to 99 percent of herb of sambucus adnata Wall.ex DC. through a pretreatment step and an extraction step. The preparation method comprises the pretreatment step and the extraction step. The preparation is a tablet, a linimentum, an effervescing agent, a lotion or a suppository prepared by adding pharmaceutically acceptable accessories in the medicinal composition. The application is application of the medicinal composition in preparation of a medicine for preventing / treating vaginitis caused by bacterial and fungal infection. The medicinal composition disclosed by the invention mainly aims at the vaginitis caused by the bacterial and fungal infection; antibacterial experiments in vitro show that the medicinal composition has a better inhibition effect on two bacteria causing the bacterial vaginitis. The medicinal composition is obtained by screening and combining of folk medicine administration habits in a Yi nationality area; medicinal materials are easy to obtain; the production and the application of the medicinal composition are facilitated.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a pharmaceutical composition and its preparation method, preparation and application. Background technique [0002] Vaginitis is a common and frequently-occurring disease in gynecology, and there is an inflammatory reaction caused by pathogens invading the vaginal mucosa. Common pathogens include bacteria, Candida and other flora. The disease not only harms women's health, but also affects the development of prenatal and postnatal health care in my country. [0003] Vaginitis can be seen in women of all ages, is a clinically frequently-occurring disease, a common disease, and is often prone to recurrence. The disease belongs to the category of "yin itching", "yin sore", "yin turbidity" and "leukorrhea" in traditional Chinese medicine. Liu Wansu's "Su Wen's Pathogenesis, Qi and Life-saving Collection", in the "Xia Xia", said that "all dampness and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61P31/04A61P31/10A61P15/02
CPCA61K36/489A61K36/185A61K36/29A61K36/35A61K2236/333A61K2236/39A61K2300/00
Inventor 昝雪峰罗永贤夏龙杨先振李海艳丁重帅
Owner CHUXIONG MEDICAL COLLEGE
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