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High-affinity medical antibacterial glycolide material and preparation method thereof

A polyglycolide, affinity technology, applied in the field of biomedical materials, can solve the problems of antibacterial, flexibility, unreasonable mechanical strength, limitations, etc., and achieve excellent antibacterial performance, strong practicability, and good application prospects. Effect

Inactive Publication Date: 2016-12-07
何仁英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the unreasonable indicators of antibacterial properties, flexibility, and mechanical strength, the usual polyglycolide materials often bring many restrictions to practical applications.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Weigh 45 parts of polyglycolide, 40 parts of ethylene bis stearic acid amide, 40 parts of collagen, 35 parts of 1,6-ethylene glycol dimethacrylate, ethylene bis stearamide 25 parts of stearic acid amide, 20 parts of bismaleamic acid, 18 parts of polyvinyl glyoxal, 10 parts of glass fiber, 10 parts of fibroin, 5 parts of wollastonite powder, 4 parts of nano titanium dioxide, aluminum silicate 4 parts of ceramic fiber, 3 parts of acetyl triethyl citrate, 2 parts of zinc stearate, 2 parts of silane coupling agent;

[0023] (2) Mix collagen, 1,6-ethylene glycol dimethacrylate, ethylene bis stearic acid amide, bismaleamic acid, polyvinyl glyoxal, and fibroin, and pass it into Fumigate with CO2 for 3 minutes, then add the fumigated material into the ultrasonic emulsification disperser, then add NaOH solution with a concentration of 3% twice the mass of the material, and ultrasonically disperse for 20 minutes under the condition of ultrasonic frequency of 20 kHz to obtain ...

Embodiment 2

[0029] (1) Weigh 50 parts of polyglycolide, 45 parts of ethylene bis stearic acid amide, 45 parts of collagen, 40 parts of 1,6-ethylene glycol dimethacrylate, ethylene bis stearamide 30 parts of stearic acid amide, 23 parts of bismaleamic acid, 20 parts of polyvinyl glyoxal, 11 parts of glass fiber, 11 parts of fibroin, 7 parts of wollastonite powder, 5 parts of nano titanium dioxide, aluminum silicate 5 parts of ceramic fiber, 4 parts of acetyl triethyl citrate, 3 parts of calcium stearate, 3 parts of aluminum zirconate coupling agent;

[0030] (2) Mix collagen, 1,6-ethylene glycol dimethacrylate, ethylene bis stearic acid amide, bismaleamic acid, polyvinyl glyoxal, and fibroin, and pass it into Fumigate with CO2 for 5 minutes, then add the fumigated material into the ultrasonic emulsification disperser, then add NaOH solution with a concentration of 3% twice the mass of the material, and ultrasonically disperse for 20 minutes under the condition of ultrasonic frequency of 28...

Embodiment 3

[0036] (1) Weigh 55 parts of polyglycolide, 50 parts of ethylene bis stearic acid amide, 50 parts of collagen, 45 parts of 1,6-ethylene glycol dimethacrylate, ethylene bis stearamide 35 parts of stearic acid amide, 26 parts of bismaleamic acid, 22 parts of polyvinyl glyoxal, 12 parts of glass fiber, 12 parts of fibroin, 8 parts of wollastonite powder, 6 parts of nano titanium dioxide, aluminum silicate 6 parts of ceramic fiber, 5 parts of acetyl triethyl citrate, 4 parts of calcium oxide, 4 parts of titanate coupling agent;

[0037](2) Mix collagen, 1,6-ethylene glycol dimethacrylate, ethylene bis stearic acid amide, bismaleamic acid, polyvinyl glyoxal, and fibroin, and pass it into Fumigate with CO2 for 7 minutes, then add the fumigated material into the ultrasonic emulsification disperser, then add NaOH solution with a concentration of 3% twice the mass of the material, and ultrasonically disperse for 20 minutes under the condition of ultrasonic frequency of 35 kHz to obtain...

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PUM

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Abstract

The invention discloses a high-affinity medical antibacterial glycolide material. The material is prepared from, by weight, 45-55 parts of polyglycollide, 40-50 parts of N,N'-ethylene hisstearamide, 40-50 parts of collagen, 35-45 parts of 1,6-ethylene glycol dimethacrylate, 25-35 parts of N,N'-ethylene hisstearamide, 20-26 parts of bi-maleamidic acid, 18-22 parts of polyvinyl alcohol condensed glyoxal, 10-12 parts of glass fiber, 10-12 parts of fimbrin, 5-8 parts of wollastonite powder, 4-6 parts of nano titanium dioxide, 4-6 parts of aluminum silicate ceramic fiber, 3-5 parts of acetyl triethyl citrate, 2-4 parts of stabilizer and 2-4 parts of coupling agent. The prepared high-affinity medical antibacterial glycolide material is good in biocompatibility and antibacterial performance, has certain flexibility and mechanical strength and can meet industrial requirements. Meanwhile, the invention further discloses a corresponding preparation method.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a high-affinity medical antibacterial polyglycolide material and a preparation method thereof. Background technique [0002] Surgical sutures refer to special threads used for ligation and hemostasis, suture hemostasis and tissue suture in surgical operations or trauma treatment. Generally, it can be divided into two categories: absorbable thread and non-absorbable thread. Absorbable sutures are further divided into: catgut, chemically synthesized sutures, and pure natural collagen sutures according to the material and degree of absorption. The main material of the chemical synthesis line is polyglycolide. However, due to the unreasonable indicators of antibacterial properties, flexibility, and mechanical strength, the usual polyglycolide materials often bring many limitations to practical applications. [0003] Biomedical materials, also known as biomaterials, refer to m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L89/00C08L29/14C08K13/04C08K7/14C08K7/08C08K5/20C08K5/103C08K3/34C08K3/22C08K5/11C08K5/098B29C47/92B29C48/92
CPCC08L67/04B29C48/92B29C2948/9258B29C2948/92704C08K2201/011C08K2201/014C08L2203/02C08L2205/025C08L2205/035C08L89/00C08L29/14C08K13/04C08K7/14C08K7/08C08K5/20C08K5/103C08K3/34C08K2003/2241C08K5/11C08K5/098
Inventor 何仁英
Owner 何仁英
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