A kind of anti-cerebral ischemia traditional Chinese medicine extract, composition and its preparation and application
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An anti-cerebral ischemia and composition technology, which is applied in the directions of drug combinations, active ingredients of hydroxyl compounds, and medical preparations containing active ingredients, etc. Literature reports, etc.
Active Publication Date: 2020-04-07
JIANGSU OCEAN UNIV
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So far, there has been no report on the anti-cerebral ischemia related research of Rumex dentata, let alone the literature report on the preparation and application of the anti-cerebral ischemia composition
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Embodiment 1
[0136] Example 1, an anti-cerebral ischemia Chinese medicine extract, the Chinese medicine extract is extracted from the underground part of Rumex dentatus L. by water extraction or alcohol extraction.
Embodiment 2
[0137] Example 2, an anti-cerebral ischemia composition, which is extracted from the underground part of Rumex dentatus L., the extraction method is as follows: the underground part of Rumex dentatus L. is washed, dried and crushed, Extract with water or alcohol solvent, combine the extracts and concentrate under low temperature and reduced pressure to obtain the extract, redissolve the extract in water, extract with ethyl acetate, combine the extract phases to obtain the extract; the extract is processed by MCI column chromatography , eluted with ethanol aqueous solution, collect 75% ethanol eluted part, namely obtain the composition with the following 15 monomeric compounds as main components:
[0138] Compound 1: sorrel;
[0139] Compound 2: Chrysophanol;
[0140] Compound 3: emodin methyl ether;
[0141] Compound 4: Quercetin;
[0142] Compound 5: emodin;
[0143] Compound 6: methyl gallate;
[0144] Compound 7: Emodin 1,6-dimethyl ether;
[0145] Compound 8: rhein; ...
Embodiment 3
[0155] Embodiment 3, an anti-cerebral ischemia traditional Chinese medicine extract preparation, which is prepared by adding the anti-cerebral ischemia traditional Chinese medicine extract described in Example 1 as an active ingredient and adding pharmaceutical excipients. The dosage form of the preparation is capsule, granule, tablet, solution, pill, transfusion or injection.
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Abstract
The invention relates to a traditional Chinese medicine extract capable of resisting cerebral ischemia. The traditional Chinese medicine extract is obtained by adopting the underground part of rumex dentatus as a raw material, and performing extraction through a water extraction or alcohol extraction method. The invention further relates to a composition capable of resisting cerebral ischemia. An extraction method comprises the following steps that the underground part of rumex dentatus is cleaned, dried and smashed, extraction is performed through water or alcohols solvents, after extraction solutions are combined, low-temperature vacuum concentration is performed to obtain an extract, after the extract is redissolved into water, ethyl acetate is adopted for extraction, extract phases are combined, and an extract is obtained; the extract is subjected to MCI column chromatography treatment, ethanol water is adopted for elution, the 75% ethyl alcohol elution portion is collected, and the compound adopting 15 monomeric compounds as main components is obtained. The invention further relates to application of the traditional Chinese medicine extract and the composition. The extract has the effect of resisting cerebral ischemia and can effectively improve cerebral injuries caused by transient cerebral ischemia or infarct.
Description
technical field [0001] The invention relates to an extract using Chinese herbal medicine as a raw material, in particular to an anti-cerebral ischemia composition and its preparation and application. Background technique [0002] Ischemic cerebrovascular disease is the most common type of cerebrovascular disease (accounting for 60-70%), and it is an urgent problem to be solved in clinical medicine. In recent years, it has shown a clear trend of younger people. The mechanism of ischemic cerebrovascular disease is still not completely clear. According to the existing knowledge, drug researchers have studied anti-platelet aggregation (aspirin, etc.), thrombolysis (streptokinase, urokinase, etc.), anticoagulation (heparin, etc.), neuroprotection, etc. (Ca 2+ Channel blockers, etc.), free radical scavenging (NXY-059, etc.) and many other aspects of work, and achieved many beneficial results. However, neuroprotective agents may aggravate cerebral hypoxia, ischemia, and acidosis;...
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