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Composite modified starch for preparing empty capsules and preparation method thereof

A technology of compound modified starch and modified starch, which is applied in the field of bioengineering, can solve problems such as uneven reaction, brittle capsule shells, and large differences in starch structure, so as to increase stability and film-forming properties, reduce production costs, and improve production efficiency effect

Active Publication Date: 2019-06-07
湖北欣恺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The specific implementation method of the above 6 patents is: after mixing one or more different starches, carry out hydroxypropylation treatment to obtain hydroxypropyl starch. Chemical reaction is easy to cause uneven reaction and affect product stability
When producing capsule shells, heating and dissolving is also required. Since starch heating and gelatinization is a complicated process, once the heating temperature is not well controlled, the quality of the produced capsules will also be unstable.
It is also reported that starch is pregelatinized after hydroxypropylation, but after starch is pregelatinized, the starch structure will often change, resulting in brittle cracks in the produced capsule shell, poor stability, and poor product transparency. And other issues
The product still cannot meet the needs of the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Preparation of modified waxy corn starch: In a 5000L pressure-resistant reaction kettle with circulating water, heating, stirring and pH tester, add 580kg of waxy corn starch (water content 14%), then gradually add water, and put The aqueous solution is adjusted to have a mass percentage of waxy cornstarch of 15%, the temperature is raised to 50°C, 15 kg of hydrochloric acid with a mass percentage of 30% is added, the pH of the aqueous solution is adjusted to 1.2, and the aqueous solution is stirred until the waxy cornstarch aqueous solution flows. When the temperature is 50°C, reduce the reaction temperature to less than 30°C, adjust the pH of the waxy cornstarch aqueous solution to 12.5 with 3% sodium hydroxide by mass, and add cyclo Propylene oxide 5.8kg, the purity of propylene oxide is 90%, heat up to 52 ° C, continue to stir for 5 hours, when the mass percentage of hydroxypropyl group is 0.25% in the waxy corn starch aqueous solution, add the mass percentage 30...

Embodiment 2

[0034] 1. Preparation of modified waxy corn starch: In a 5000L pressure-resistant reaction kettle with circulating water, heating, stirring and pH tester, add 580kg of waxy corn starch (water content 14%), then gradually add water, and put The aqueous solution is adjusted until the mass percentage of waxy cornstarch is 20%, the temperature is raised to 50°C, 15 kg of hydrochloric acid with a mass percentage of 30% is added, the pH of the aqueous solution is adjusted to 1.5, and the aqueous solution is stirred until the waxy cornstarch aqueous solution flows. When the temperature is 50°C, reduce the reaction temperature to less than 30°C, adjust the pH of the waxy cornstarch aqueous solution to 12.5 with 3% sodium hydroxide by mass, and add cyclo Propylene oxide 5.8kg, the purity of propylene oxide is 90%, heat up to 52 ° C, continue to stir for 5 hours, when the mass percentage of hydroxypropyl group is 0.25% in the waxy corn starch aqueous solution, add the mass percentage 30...

Embodiment 3

[0040] 1. Preparation of modified waxy corn starch: In a 5000L pressure-resistant reaction kettle with circulating water, heating, stirring and pH tester, add 580kg of waxy corn starch (water content 14%), then gradually add water, and put Adjust the aqueous solution to a mass percentage of waxy cornstarch of 25%, heat up to 50°C, add 15kg of hydrochloric acid with a mass percentage of 30%, adjust the pH of the aqueous solution to 2.0, and keep stirring until the fluidity of the waxy cornstarch aqueous solution When the temperature is 50, reduce the reaction temperature to less than 30°C, adjust the pH of the waxy cornstarch aqueous solution to 12.5 with 3% sodium hydroxide by mass percentage, and add epoxy Propane 5.8kg, the purity of propylene oxide is 90%, heat up to 52 ℃, continue to stir for 6 hours, when the mass percentage of hydroxypropyl group is 0.25% in the waxy corn starch aqueous solution, add the mass percentage 30% hydrochloric acid, adjust the pH to 6.5, stop t...

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Abstract

The invention provides composite modified starch for preparing hollow capsules and a preparation method of the composite modified starch. The composite modified starch comprises the following components in percentage by mass: 15-30% of wax corn modified starch, 15-40% of cassava modified starch, 15-25% of potato modified starch, 5-10% of sticky rice modified starch and 10% of water. The preparation method comprises the following steps: 1, preparing the wax corn modified starch; 2, preparing the cassava modified starch; 3, preparing the potato modified starch; 4, preparing the sticky rice modified starch; 5, preparing the composite modified starch. By adopting the preparation method, the molecular weights of different types of starch of different components can be adjusted to appropriate ranges through acid degradation treatment, the composite modified starch can be relatively applicable to high-solid content low-viscosity sol requirements in a hollow capsule preparation process, and the viscosity of a sol liquid of which the solid content is 25% when the hollow capsules are produced is within 1,000-1,200 cpms.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to a compound modified starch for preparing hollow capsules and a preparation method thereof. Background technique [0002] There are two main ways to prepare hollow capsules, one is the capsule made from animal gelatin as the main raw material. Because gelatin is of animal origin, there are safety risks, and it is not suitable for use by Islamic and Jewish believers. In addition, due to the impact of the "shoe leather capsule" incident, the public's distrust of gelatin capsules has increased. In recent years, non-gelatin materials have been used to prepare gelatin capsules. Research on capsules is on the rise, aimed at avoiding infectious diseases without the use of gelatin of animal origin. The other is a capsule made from plants and microbial polysaccharides such as cellulose and its derivatives, pullulan, starch and its derivatives. Among them, starch is another abundant natural ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L3/08C08L3/00A61K9/48A61K47/36A23L29/30A23P10/30
CPCA23V2002/00A61K9/4816C08L3/08C08L2203/16C08L2205/025C08L2205/035C08L3/00A23V2250/5118
Inventor 李廷明徐洪宣代堂惠白超峰高新峰陆锋吴莹黄艳
Owner 湖北欣恺生物科技有限公司
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