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Anticancer composition, preparation containing same and preparation method thereof

A composition and anti-cancer drug technology, applied in the field of medicine, can solve the problems of incompleteness and slow drug absorption, and achieve the effects of fast absorption, small dosage and stable quality

Inactive Publication Date: 2017-01-18
YANGLING CHARISMA BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral liquid is a sugar-free dosage form, which can effectively overcome the disadvantages of Xiaoaiping ordinary solid oral preparations, which have strong hygroscopicity and slow disintegration due to the fact that it contains more extracts extracted from traditional Chinese medicines, resulting in slow and incomplete drug absorption. In addition to the advantages of small dose, fast absorption, stable quality, convenient carrying and taking, more importantly, the stability is better than that of the original sugar dosage form, and at the same time, the scope of taking patients has been expanded, including malignant tumors with abnormal blood sugar.

Method used

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  • Anticancer composition, preparation containing same and preparation method thereof
  • Anticancer composition, preparation containing same and preparation method thereof
  • Anticancer composition, preparation containing same and preparation method thereof

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preparation example Construction

[0023] Specifically, a sugar-free preparation of Xiaoaiping oral liquid, the preparation process see figure 1 . It is characterized in that the weight ratio of the preparation is:

[0024] Tongguanteng medicinal material extract (calculated as Tongguanteng medicinal material) 1000g

[0025] Sucralose 0.01~10g

[0026] Sodium benzoate 0.02~5g

[0027] Add purified water to 1000ml

[0028] And, the preparation of a sugar-free Xiaoaiping oral liquid is characterized in that its preparation steps are:

[0029] (1) Tongguanteng extract: take 1000g of Tongguanteng medicinal material, soak for 12 hours, add water and decoct three times, the first time for 2 hours, the second time for 1.5 hours, the third time for 1 hour, combine the decoction, filter, and refrigerate for 12 hours, the supernatant was taken and concentrated to a relative density of 1.15 (55°C).

[0030] (2) Preparation of oral liquid: take additional sucralose, sodium benzoate, add appropriate amount of water, d...

Embodiment 1

[0041] Embodiment 1 prescription process optimization

[0042] The present invention has carried out following prescription and technology preferably:

[0043] (1) Preparation of extraction extract: Take 2.5kg of Tengguan vine and put it in a 50L stainless steel bucket, add 30L of water to soak for 12 hours, decoct for extraction for 2 hours, and extract for later use; add 20L of water for decoction and extract for 1.5 hours, and extract for later use , add 20L water to decoct the dregs and extract for 1 hour, combine three extracts, filter, refrigerate at 2-8°C for 12 hours, take the supernatant, concentrate to a relative density of 1.14 (53°C), and obtain 1.69kg of extract (about 1.48L).

[0044] (2) Preliminary screening of prescriptions: 200ml of the preparation obtained in the previous step (corresponding to the weight of the vine extract is 135g), and weigh 6 parts in parallel. The following prescription is prepared, and the control has a glycoform (adding 20 g of sucr...

Embodiment 2

[0052] The preparation of embodiment 2 sugar-free type Xiaoaiping oral liquid preparation

[0053] Tongguanteng medicinal material extract (calculated as Tongguanteng medicinal material) 1000g

[0054] Sucralose 0.2g

[0055] Sodium Benzoate 2g

[0056] Add purified water to 1000ml

[0057] Take 1000g of Tongguan vine medicinal material, soak for 12 hours, add water and decoct three times, the first time for 2 hours, the second time for 1.5 hours, the third time for 1 hour, combine the decoction, filter, refrigerate for 12 hours, take the supernatant, concentrate to a relative density of 1.15 (55°C). Separately take sucralose, sodium benzoate, add appropriate amount of water, dissolve, filter, mix with the above concentrated solution, add appropriate amount of purified water to make 1000ml, stir well, potting, and sterilize to obtain.

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Abstract

The invention relates to the technical field of medicines, in particular to an anticancer composition, a preparation containing the same and a preparation method thereof. The composition comprises, by mass, 1000 parts of marsdenia tenacissima and / or marsdenia tenacissima extract and 1-10 parts of corrigent. A preparation prescription process of the anticancer composition is preferred and optimized, nutritional sugars such as saccharose and glucose affecting blood glucose are not adopted, and a sweetening agent having no influence on the blood glucose after taking is adopted. The sugar-free cancer eliminating oral solution prepared by adopting the method is better than an existing sugar in quality stability, the preparation has a good mouthfeel, the range of patients suitable for taking is widened, including populations with pathoglycemia.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an anticancer composition, a medicament containing the composition and a preparation method thereof. Background technique [0002] Cancer is currently one of the diseases that threaten human health the most. In medicine, cancer refers to malignant tumors originating from epithelial tissue, which is the most common type of malignant tumors. Correspondingly, malignant tumors originating in mesenchymal tissue are collectively referred to as sarcomas. There are a few malignant tumors not named according to the above principles, such as Wilms tumor, malignant teratoma, etc. Generally speaking, "cancer" generally refers to all malignant tumors. Tumor is a new organism formed by the body under the action of various tumorigenic factors, and the cells of local tissues lose their normal regulation of their growth at the gene level, resulting in abnormal proliferation and differentiatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/27A61P35/00
CPCA61K36/27A61K9/0095A61K47/183A61K47/22A61K47/26A61K2236/331A61K2236/39A61K2236/51
Inventor 周小园郁慧高建昌任建芳李选玲杨朝福
Owner YANGLING CHARISMA BIO PHARMA CO LTD
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