Preparation method of damp-proof potassium aspartate ball
A technology of potassium aspartate and pellets, which is applied in microcapsules, metabolic diseases, capsule delivery, etc. It can solve problems such as unsatisfactory coating moisture-proof effect, difficulties in industrial production, and difficulties in solvent recovery, so as to reduce the difficulty of preparation and Production cost, increase in stability, effect of reducing hygroscopicity
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[0018] Example 1:
[0019] Prescription composition: potassium aspartate 500g; microcrystalline cellulose 100g; hydroxypropyl methylcellulose 25g; PEG6000 10g; stearic acid 50g; magnesium stearate 15g.
[0020] Preparation process: Weigh the recipe quantities of potassium aspartate, microcrystalline cellulose and hydroxypropyl methylcellulose, prepare soft material with 50% ethanol as a binder, place the soft material in an extruder at 30 rmp Extruded under the conditions, firstly spheronized at 30rmp for 2min, and then at 60rmp for 10min in the spheronizer. The pellets were dried in an oven at 40°C for 12 hours, sieved, and the particles with a particle size between 16 and 24 meshes were taken. Pass stearic acid and PEG6000 through an 80-mesh sieve according to the recipe and mix. Add the prepared spherical granules into the coating pan, slowly add the hot melt coating material to the coating pan, and perform the coating according to the following parameters: temperature 60...
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[0021] Example 2
[0022] Prescription composition: potassium aspartate 500g; mannitol 100g; sodium carboxymethyl starch 25g; povidone K30 12g; stearic acid 60g; talc 20g.
[0023] Preparation process: Weigh the recipe quantities of potassium aspartate, mannitol and sodium carboxymethyl starch, use 50% (v / v) ethanol as a binder to prepare a soft material, place the soft material in an extruder at 30 rmp Extruded under the conditions, the strip extrudate was first spheronized at 30rmp for 2min in the spheronizer, and then spheronized at 60rmp for 10min. The pellets were dried in an oven at 40°C for 12 hours, sieved, and the particles with a particle size between 16 and 24 meshes were taken. Pass stearic acid and povidone through an 80-mesh sieve according to the prescription, and mix well. Add the prepared spherical granules into the coating pan, slowly add the hot melt coating material to the coating pan, and perform the coating according to the following parameters: tempera...
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[0024] Example 3
[0025] Prescription composition: potassium aspartate 500g; lactose 80g; croscarmellose sodium 25g; glycerol monostearate 50g; PEG6000 10g; talc 15g.
[0026] Preparation process: Weigh the recipe quantities of potassium aspartate, lactose and croscarmellose sodium, use 50% (v / v) ethanol as a binder to prepare a soft material, and place the soft material in an extruder The extrudate was extruded at 30 rmp in the spheronizer, and the extrudate was first spheronized at 30 rmp for 2 min, and then spheronized at 60 rmp for 10 min. The pellets were dried in an oven at 40°C for 12 hours, sieved, and the particle size was between 16-24 mesh. Pass glycerol monostearate and PEG6000 through an 80-mesh sieve according to the recipe, and mix well. Add the prepared spherical granules into the coating pan, slowly add the hot melt coating material to the coating pan, and perform the coating according to the following parameters: temperature 60-70 °C, main engine speed 30 ...
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