Blackberry lily rhizome antivirus injection, preparation method thereof, and intravenous administration blackberry lily rhizome antivirus injection

An injection and anti-virus technology, applied in anti-viral agents, drug delivery, pharmaceutical formulations, etc., can solve problems such as inconvenient use, pain, congestion, and even muscle necrosis, so as to avoid inconvenient use, avoid degradation, prolong Effect of quality expiration date

Inactive Publication Date: 2017-03-08
威海恒基伟业信息科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Since the existing route of administration of Shegan Antiviral Injection is intramuscular injection, it is inconvenient to use clinically, the administration site of the patient is painful, and it is easy to cause adverse reactions such as congestion and even muscle necrosis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 500g of Shegan, 400g of Honeysuckle, 300g of Peilan, 200g of Capillary, 150g of Bupleurum, 250g of Dandelion, 400g of Radix Isatidis, and 300g of Folium Folium, add purified water 3 times the weight of the medicinal material, and use steam distillation to collect the distillate as 1% of the medicinal material. / 5, the distilled liquid is redistilled, and the refined liquid is about 1 / 8 of the weight of the medicinal material, and it is used for later use; the distilled medicinal residue is added to purified water 5 times the weight of the medicinal material, and boiled and decocted twice, each time for 1 hour, Filter through filter paper, combine the two filtrates, concentrate the filtrate, add 0.06% of the weight of the concentrated solution to the clarifier B, heat to 70-90°C, let stand for 2 hours, then add 0.03% of the weight of the concentrated solution to clarify Agent A, after standing still for 4 hours, centrifuge, pour out the supernatant, and concentrate t...

Embodiment 2

[0041] Take 50g of Shegan, 900g of honeysuckle, 100g of Peilan, 300g of capillary, 150g of Bupleurum, 250g of dandelion, 100g of Radix Isatidis, and 200g of Folium Folium. / 6, the distilled liquid is redistilled, and the refined liquid is about 1 / 7 of the weight of the medicinal material, and it is used for later use; the distilled medicinal residue is added to purified water 6 times the weight of the medicinal material, and boiled and decocted twice, each time for 1 hour, Filter through filter paper, combine the two filtrates, concentrate the filtrate, add 0.04% of the weight of the concentrated solution to the clarifier B, heat to 70-90°C, let stand for 2 hours, then add 0.02% of the weight of the concentrated solution to clarify Agent A, after standing for 4 hours, centrifuge, pour out the supernatant, and concentrate to 3g of crude drug per ml; add ethanol under slow stirring, add ethanol to make the alcohol content 75%, refrigerate at 4-8°C For 48 hours, filter through fi...

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PUM

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Abstract

The invention relates to a blackberry lily rhizome antivirus injection, a preparation method thereof, and an intravenous administration way of the blackberry lily rhizome antivirus injection, and belongs to the field of traditional Chinese medicine preparations. The raw medicinal materials of the blackberry lily rhizome antivirus injection comprise blackberry lily rhizome, honeysuckle flower, fortune eupatorium herb, capillary wormwood herb, Chinese thorowax root, Mongolian dandelion herb, indigowoad root, and indigowoad leaf, wherein the blackberry lily rhizome is 1-1000 parts by weight, the honeysuckle flower is 1-1000 parts by weight, the fortune eupatorium herb is 1-1000 parts by weight, the capillary wormwood herb is 1-1000 parts by weight, the Chinese thorowax root is 1-1000 parts by weight, the Mongolian dandelion herb is 1-1000 parts by weight, the indigowoad root is 1-1000 parts by weight, and the indigowoad leaf is 1-1000 parts by weight. Effective active ingredients of each component of the blackberry lily rhizome antivirus injection are obtained by virtue of multiple technical means including performing steam distillation, water boiling, adding of a clarifier, alcohol precipitation, water precipitation and the like on the raw medicinal materials in a prescription, and a finished product preparation is obtained by virtue of sub-packaging and sterilization. The blackberry lily rhizome antivirus injection provided by the invention is high in bioavailability, simple and convenient in use, and less in untoward effect, and avoids untoward effects of inconvenience in clinical use, pain at administration places of patients, easily-caused blood stasis even muscular death, and the like.

Description

technical field [0001] The invention relates to a Shegan antiviral injection, its preparation method and intravenous administration of the Shegan antiviral injection, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Shegan, also known as black fan, black pu, ghost fan, wild day lily, flat bamboo, golden butterfly, etc., is the dried rhizome of the perennial herbaceous plant Shegan; bitter and cold in nature; the main ingredients are Sheganding, irisin, iris flavonoids , Iris flavonoid glycosides, Sheganol, etc. Shegan water decoction has the effect of resisting pathogenic microorganisms. [0003] Honeysuckle, alias honeysuckle flower, silver flower, egret flower, Su flower, golden flower, double flower, two flower, two treasure flower, is a perennial semi-perennial green winding woody plant Lonicera, red gland honeysuckle, mountain silver flower Or the dry flower buds of Lonicera trichomes or the flowers with early opening;...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K9/08A61P31/12
CPCA61K36/88A61K9/0019A61K9/08A61K36/195A61K36/233A61K36/28A61K36/288A61K36/315A61K36/355A61K36/704A61K36/855A61K2236/331A61K2236/39A61K2236/55
Inventor 蔡颖
Owner 威海恒基伟业信息科技发展有限公司
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