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Flexible artificial skin and preparing method thereof

An artificial skin and flexible technology, applied in the field of flexible artificial skin and its production, can solve the problems of affecting cell colonization and growth, insufficient strength of artificial skin, long retention time, etc., to facilitate transportation and exchange, avoid toxic side effects, and quality control. handy effect

Active Publication Date: 2017-03-08
ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydrogels such as sodium hyaluronate, chitosan, chondroitin sulfate, and dermatan sulfate have the problems of insufficient artificial skin strength and poor air permeability. role of growth
However, medical polymer materials such as polyurethane, or silicone rubber, or polyethylene glycol, or ethylene terephthalate, solve the strength problem of artificial skin, but their hyd

Method used

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  • Flexible artificial skin and preparing method thereof
  • Flexible artificial skin and preparing method thereof
  • Flexible artificial skin and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Preparation of braided thread: Take 2 strands of PLA filaments with an average fineness of 8tex, and twist the 2 strands of filaments into a braided thread at 300 twists / m.

[0032] 2) making braided layer: adopt Hercules braiding process to make braided layer, with a porosity of 25% and a thickness of 300 μm;

[0033] 3) Atmospheric pressure plasma treatment: the gas used is helium, the gas temperature is 90°C, the flow rate is 4L / min, and the treatment time is 4min;

[0034] 4) Configure the hydrogel solution: take sodium hyaluronate and deionized water according to the molar ratio of 1:50 to configure the hydrogel solution, and mix the epidermal growth factor, nano-silver ions and hydrogel material according to the ratio of 10:1:300 The molar ratio is evenly mixed;

[0035] 5) The braided layer is coated with hydrogel: under sterile conditions, the hydrogel solution is mixed at 1.5 mg / cm 2 Evenly coated on the surface of the braided layer, then cured at 4°C for ...

Embodiment 2

[0037] 1) Preparation of braided wire: Take 2 strands of PGA filaments with an average fineness of 10tex, and twist the 2 strands of filaments into a braided wire at 250 twists / m.

[0038] 2) making the braided layer: adopting two-dimensional triaxial weaving process to make the braided layer, with a porosity of 15% and a thickness of 400 μm;

[0039] 3) Atmospheric pressure plasma treatment: the gas used is helium, the gas temperature is 100°C, the flow rate is 6L / min, and the treatment time is 6min;

[0040] 4) Configure the hydrogel solution: take sodium hyaluronate and deionized water according to the molar ratio of 1:30 to configure the hydrogel solution, and mix the epidermal growth factor, nano-silver ions and hydrogel material according to the ratio of 10:1:400 The molar ratio is evenly mixed;

[0041] 5) The braided layer is coated with hydrogel: under sterile conditions, the hydrogel solution is mixed at 1.0 mg / cm 2 Evenly coated on the surface of the braided layer...

Embodiment 3

[0043] 1) Preparation of braided wire: Take 3 strands of PLGA filaments with an average fineness of 6tex, and twist the 3 strands of filaments into a braided wire at 200 twists / m.

[0044] 2) making braided layer: adopt Hercules weaving process to make braided layer, with a porosity of 30% and a thickness of 600 μm;

[0045] 3) Atmospheric pressure plasma treatment: the gas used is oxygen, the gas temperature is 100°C, the flow rate is 8L / min, and the treatment time is 8min;

[0046] 4) Configure the hydrogel solution: take sodium hyaluronate and deionized water according to the molar ratio of 1:40 to configure the hydrogel solution, and mix the epidermal growth factor, nano-silver ions and hydrogel material according to the ratio of 10:1:500 The molar ratio is evenly mixed;

[0047] 5) The braided layer is coated with hydrogel: under sterile conditions, add the hydrogel solution at 0.8 mg / cm 2Evenly coated on the surface of the braided layer, then cured at 4°C for 1 hour, a...

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Abstract

The invention relates to a flexible artificial skin. The flexible artificial skin comprises a hydrogel layer and a braid layer, and the hydrogel layer is arranged on the braid layer; the braid layer is a high polymer degradable material; the hydrogel layer contains cell growth factors and nano-silver. The flexible artificial skin has the advantages that firstly, the material adopted in the artificial skin is the high polymer degradable material, and the material is easy to obtain and good in biocompatibility; secondly, the artificial skin obtained through a knitting method has a plurality of pores, transportation and exchange of nutrient substance are benefited, and area size can be freely adjusted; thirdly, by adjusting the knitting method and changing degree of compactness and porosity of the braid layer, adjustment on physical properties of ductility, toughness, mechanical strength and the like of the artificial skin are achieved; fourthly, by the adoption of treatment of atmospheric pressure plasma jet, fiber surface area of the braid layer is increased, a contact angle of the surface of the material is reduced, and hydraulic conductivity and cellular affinity are improved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a flexible artificial skin and a manufacturing method thereof. Background technique [0002] As the largest organ in the human body, the skin is a natural barrier between the human body and the external environment, and has the functions of protection, regulation, and excretion. When skin defects and abnormalities are caused by inflammation, ulcers, trauma, burns, surgery, etc., it will affect the appearance of the patient in the slightest, and cause infection or a large loss of electrolytes and water in severe cases, resulting in the death of the patient. Especially for the treatment of large-area skin defects, the key is to seal the wound as soon as possible, reduce the consumption of the body and the disorder of the internal environment, prevent the invasion of harmful substances, and promote the regeneration of the wound skin. At present, autologous skin transplantation i...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/18A61L27/50A61L27/52A61L27/54
CPCA61L27/18A61L27/50A61L27/52A61L27/54A61L27/60A61L2300/104A61L2300/414A61L2300/604C08L5/08
Inventor 周佳厉民王峥
Owner ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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