Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of flexible artificial skin and its preparation method

An artificial skin and flexible technology, applied in the field of flexible artificial skin and its production, can solve the problems of affecting cell colonization and growth, insufficient artificial skin strength, aseptic inflammation, etc., to facilitate transportation and exchange, avoid toxic side effects, prolong effect of shelf life

Active Publication Date: 2019-08-02
ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydrogels such as sodium hyaluronate, chitosan, chondroitin sulfate, and dermatan sulfate have the problems of insufficient artificial skin strength and poor air permeability. role of growth
However, medical polymer materials such as polyurethane, or silicone rubber, or polyethylene glycol, or ethylene terephthalate, solve the strength problem of artificial skin, but their hydrophilicity is not high, and they often degrade slowly and last for a long time. If it does not degrade for a long time, it will cause foreign matter residue, cause aseptic inflammation, and affect the colonization and growth of its own cells on the wound surface. Moreover, because these materials cannot participate in physiological metabolism, they can only be used as outer dressings.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of flexible artificial skin and its preparation method
  • A kind of flexible artificial skin and its preparation method
  • A kind of flexible artificial skin and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Preparation of braided yarn: Take 2 strands of PLA filament with an average fineness of 8 tex, and twist the 2 strands of filament at 300 twists / m into a braided yarn.

[0032] 2) Fabrication of the braided layer: The braided layer is made by the Heglis weaving process, with a porosity of 25% and a thickness of 300μm;

[0033] 3) Atmospheric pressure plasma treatment: the gas used is helium, the gas temperature is 90°C, the flow rate is 4L / min, and the treatment time is 4min;

[0034] 4) Configure the hydrogel solution: Take sodium hyaluronate and deionized water according to the molar ratio of 1:50 to configure the hydrogel solution, and mix the epidermal growth factor, nano silver ions and hydrogel materials according to 10:1:300 The molar ratio of the mixture is uniformly mixed;

[0035] 5) The braided layer is coated with hydrogel: under aseptic conditions, the hydrogel solution is applied at 1.5 mg / cm 2 Coat evenly on the surface of the braided layer, then solidify at 4...

Embodiment 2

[0037] 1) Preparation of braided yarn: Take 2 strands of PGA filament with an average fineness of 10 tex, and twist the 2 strands of filament into a braided yarn at 250 twists / m.

[0038] 2) Fabrication of braided layer: the braided layer is fabricated by a two-dimensional triaxial weaving process with a porosity of 15% and a thickness of 400μm;

[0039] 3) Atmospheric pressure plasma treatment: The gas used is helium, the gas temperature is 100°C, the flow rate is 6L / min, and the treatment time is 6min;

[0040] 4) Configure the hydrogel solution: Take sodium hyaluronate and deionized water according to the molar ratio of 1:30 to prepare the hydrogel solution, and mix the epidermal growth factor, nano silver ions and hydrogel materials according to 10:1:400 The molar ratio of the mixture is uniformly mixed;

[0041] 5) The braided layer is coated with hydrogel: under aseptic conditions, the hydrogel solution is 1.0mg / cm 2 Coat evenly on the surface of the braided layer, then solidify...

Embodiment 3

[0043] 1) Preparation of braided yarn: take 3 strands of PLGA filament with an average fineness of 6 tex, and twist 3 strands of filament at 200 twists / m into a braided yarn.

[0044] 2) Fabrication of the braided layer: The braided layer is made by the Heglis weaving process, with a porosity of 30% and a thickness of 600μm;

[0045] 3) Atmospheric pressure plasma treatment: The gas used is oxygen, the gas temperature is 100°C, the flow rate is 8L / min, and the treatment time is 8min;

[0046] 4) Configure the hydrogel solution: Take sodium hyaluronate and deionized water according to the molar ratio of 1:40 to configure the hydrogel solution, and mix the epidermal growth factor, nano silver ions and hydrogel materials according to 10:1:500 The molar ratio of the mixture is uniformly mixed;

[0047] 5) The braided layer is coated with hydrogel: under aseptic conditions, the hydrogel solution is applied at 0.8 mg / cm 2 Coat evenly on the surface of the braided layer, then solidify at 4°C...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention relates to a flexible artificial skin. The flexible artificial skin comprises a hydrogel layer and a braid layer, and the hydrogel layer is arranged on the braid layer; the braid layer is a high polymer degradable material; the hydrogel layer contains cell growth factors and nano-silver. The flexible artificial skin has the advantages that firstly, the material adopted in the artificial skin is the high polymer degradable material, and the material is easy to obtain and good in biocompatibility; secondly, the artificial skin obtained through a knitting method has a plurality of pores, transportation and exchange of nutrient substance are benefited, and area size can be freely adjusted; thirdly, by adjusting the knitting method and changing degree of compactness and porosity of the braid layer, adjustment on physical properties of ductility, toughness, mechanical strength and the like of the artificial skin are achieved; fourthly, by the adoption of treatment of atmospheric pressure plasma jet, fiber surface area of the braid layer is increased, a contact angle of the surface of the material is reduced, and hydraulic conductivity and cellular affinity are improved.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and particularly relates to a flexible artificial skin and a manufacturing method thereof. Background technique [0002] As the organ with the largest area of ​​the human body, the skin is a natural barrier between the human body and the external environment, and has the functions of protection, regulation and excretion. When skin defects and abnormalities are caused by inflammation, ulcers, trauma, burns, surgery, etc., it can affect the appearance of the patient, and cause infection or a large loss of electrolyte and water, leading to the death of the patient. Especially for the treatment of large-area skin defects, the key is to seal the wound as soon as possible, reduce the body's consumption and internal environment disturbance, prevent the invasion of harmful substances, and promote the regeneration of the wound skin. At present, autologous skin transplantation is often used in medicine for ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61L27/60A61L27/18A61L27/50A61L27/52A61L27/54
CPCA61L27/18A61L27/50A61L27/52A61L27/54A61L27/60A61L2300/104A61L2300/414A61L2300/604C08L5/08
Inventor 周佳厉民王峥
Owner ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com