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3D printed radix notoginseng total saponins orally disintegrating tablet and preparation method thereof

A kind of Panax notoginseng saponins, 3D printing technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. Fast-acting, fast-disintegrating effect

Inactive Publication Date: 2017-03-22
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the notoginseng preparations on the market include: tablets (common tablets, dispersible tablets, chewable tablets, effervescent tablets), capsules (hard capsules, soft capsules), dripping pills, granules, injections, and there are no orally disintegrating tablets.

Method used

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  • 3D printed radix notoginseng total saponins orally disintegrating tablet and preparation method thereof
  • 3D printed radix notoginseng total saponins orally disintegrating tablet and preparation method thereof
  • 3D printed radix notoginseng total saponins orally disintegrating tablet and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0032] A preparation method for 3D printing orally disintegrating Panax notoginseng saponins, characterized in that it comprises the following steps:

[0033] (1) Calculated by weight percentage, 10-30% of Panax notoginseng saponins, 15-35% of microcrystalline cellulose, 30-50% of mannitol, 10-15% of povidone, 0-0.5% of micropowder silica gel, Mix 0-0.5% of the flavoring agent evenly in proportion, and put it into the powder box of the 3D printing rapid prototyping machine as a medicine powder;

[0034] (2) Put the adhesive into the ink cartridge; preferably, the adhesive is water, 30% to 75% ethanol solution, starch slurry, povidone in water or ethanol solution;

[0035] (3) According to the pre-set parameters, model and import it into the control system of the 3D printing rapid prototyping machine;

[0036] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print oral disintegrating tablets of Panax notoginseng saponins: the ...

Embodiment 1

[0042] The prescription of the orally disintegrating tablets of 3D printed Panax notoginseng saponins in this embodiment is as follows:

[0043]

[0044]

[0045] The 3D printing parameters of this embodiment are as follows:

[0046]

[0047] The preparation method is as follows:

[0048] 1. Mix Panax notoginseng saponins, microcrystalline cellulose PH101, mannitol, and povidone K30 evenly in proportion, and put them into the powder box of the LTY-200 three-dimensional printing rapid prototyping machine;

[0049] 2. Put the adhesive into the cartridge;

[0050] 3. According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0051]4. The computer outputs instructions to control the 3D printer to print oral disintegrating tablets of Panax notoginseng saponins: the powder spreading device first spreads a layer of powder with a thickness of 0.1mm o...

Embodiment 2

[0054] The prescription of the orally disintegrating tablets of 3D printed Panax notoginseng saponins in this embodiment is as follows:

[0055]

[0056]

[0057] The 3D printing parameters of this embodiment are as follows:

[0058]

[0059] The preparation method is as follows:

[0060] 1. Mix Panax notoginseng saponins, microcrystalline cellulose PH101, mannitol, and povidone K30 evenly in proportion, and put them into the powder box of the LTY-200 three-dimensional printing rapid prototyping machine;

[0061] 2. Put the adhesive into the cartridge;

[0062] 3. According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0063] 4. The computer outputs instructions to control the 3D printer to print oral disintegrating tablets of Panax notoginseng saponins: the powder spreading device first spreads a layer of powder with a thickness of 0.1mm ...

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Abstract

The invention discloses a 3D printed radix notoginseng total saponins orally disintegrating tablet and a preparation method thereof. The preparation method comprises the steps of uniformly mixing, in percentage by weight, 10-30% of radix notoginseng total saponins, 15-35% of microcrystalline cellulose, 30-50% of mannitol, 10-15% of povidone, 0-0.5% of micropowder silica gel and 0-0.5% of a flavoring agent, and putting a mixture into a powder box; putting an adhesive into an ink box; performing modeling according to preset parameters, and importing a model to a control system of a 3D printing and fast-forming machine; outputting an instruction by the control system to print a radix notoginseng total saponins orally disintegrating tablet; and after a dispersible tablet is adhered and dried, taking out the tablet to obtain the 3D printed radix notoginseng total saponins orally disintegrating tablet. According to the 3D printed radix notoginseng total saponins orally disintegrating tablet and the preparation method, the radix notoginseng total saponins orally disintegrating tablet printed by adopting a 3DP technology has the characteristics of simple process, higher disintegrating speed, higher bio-utilization degree, more convenient taking and the like, can be disintegrated in saliva of the oral cavity, and is especially suitable for bedridden patients, apoplectic hemiplegia patients with difficulty in swallowing or old people; and the effect-taking speed is higher, the treatment requirements of acute diseases such as coronary heart diseases, angina and the like are met, and personalized drug administration and accurate treatment can be realized.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a 3D printed orally disintegrating tablet of Panax notoginseng saponins and a preparation method thereof. Background technique [0002] There are 290 million people suffering from cardiovascular disease in China, 1 out of every 5 adults suffers from cardiovascular disease, and 1 person dies from cardiovascular disease every 10 seconds. Cardiovascular disease accounts for more than 40% of residents' death from diseases, higher than tumors and other diseases, and is the first cause of death among Chinese residents, while the prevalence and mortality of cardiovascular diseases are still on the rise. With the increase of patients with cardiovascular and cerebrovascular diseases, cardiovascular and cerebrovascular drugs have become the largest category of drugs in the world pharmaceutical market. [0003] Panax notoginseng is the dry root of Panax notoginseng (Bur...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/20A61K47/38A61K47/32A61P9/00A61P9/10A61P9/06A61P7/04A61P25/02A61K125/00
Inventor 刘强曹思玮安佰超乡世健洪军辉阮世发朱红霞翁立冬陈活记
Owner SOUTHERN MEDICAL UNIVERSITY
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