Composition comprising microcapsules containing particles with a high wet point
A composition and granule technology, which is applied in the direction of medical preparations containing active ingredients, skin care preparations, cosmetics, etc., and can solve problems such as composition thickening
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[0071] According to another preferred embodiment, the microcapsules comprise:
[0072] - a core comprising at least one organic material,
[0073] - at least one layer of coating surrounding said core, said at least one layer of coating comprising a binder and at least one optionally porous particle with a high humidity point, said binder being selected from at least one polymer, at least one lipid-based material, and mixtures thereof, preferably mixtures thereof,
[0074] - an outer layer comprising a hydrophilic polymer.
[0075] Preferably, the core comprises as said organic material at least one monosaccharide or a derivative thereof, in particular a monosaccharide advantageously selected from the group consisting of mannitol, erythritol, xylitol, sorbitol and mixtures thereof - a polyol, preferably mannitol.
[0076] Preferably, said at least one layer of coating surrounding said core comprises at least one hydrophilic polymer selected from:
[0077] - homopolymers or...
Embodiment
[0951] I. Microcapsules
[0952] In the following, different examples of the preparation of microcapsules according to the invention are described in order to illustrate the invention.
[0953] The following particles according to the invention were used in the examples:
[0954] - OPTIMAT 2550OR dispatched by WORLD MINERALS (IMERYS), named "A" in the example below,
[0955] - Silica (amorphous silica microspheres (5 μm)), designated "B" in the examples below,
[0956] - SUNSPHERE H 51 dispatched by AGC SI-TECH, named "C" in the example below,
[0957] - PMMA (hollow spheres CREUSES (10 microns) of polymethylmethacrylate) dispatched by SENSIENT, named "D" in the example below,
[0958] - Cellulose (CELLULOBEADS USF dispatched by KOBO), named "E" in the example below,
[0959] - Airgel in water with 98% dry matter (DOW CORNING VM-2270AEROGEL FINE PARTICLES dispatched by DOW CORNING), named "F" in the example below.
example 1
[0961] Example 1a : STARPHERE-F Seed (seed) 4050 (core ball containing 20% to 30% mannitol; 20% to 30% microcrystalline cellulose; and 40% to 50% cornstarch) was used as the core .
[0962] 50.0 g of HPMC (hydroxypropyl methylcellulose) was added to a mixed solution of 750 g of water and 3000.0 g of ethanol, and was completely dissolved at room temperature. With 150g of silylated silica airgel (Dow VM-2270AEROGEL FINE PARTICLES; Airgel with 98% dry matter present in water) and 350g of perlite-MSZ12 were added to the resulting mixture, fully dispersed using a homogenizer (3000rpm, 20min), to prepare the first Fill with coating solution.
[0963] 450.0 g of STP-F Seed 4050 was introduced into the fluidized bed coating system (Glatt GPCG 1, tangential spray) as the core seed and then subjected to the inner layer filling solution at a feed rate of 450ml / h to 500ml / h to obtain particles with a core of "STP-F Seed 4050" coated with a filler layer.
[0964] Coated particles ...
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