Luteolin-Zn complex capable of promoting consumption of cell glucose as well as preparation and application

A technology of luteolin and complexes, applied in the field of natural product modified medicines, can solve the problems of insignificant hypoglycemic effect, toxic and side effects, etc., and achieve the effects of enhancing biological activity, low cost, and improving physical and chemical properties

Active Publication Date: 2017-05-10
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Luteolin has a variety of physiological activities, such as antioxidant, antibacterial, antiviral, anti-inflammatory, anti-tumor, etc. It is widely used in medicine, health care and other fiel

Method used

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  • Luteolin-Zn complex capable of promoting consumption of cell glucose as well as preparation and application
  • Luteolin-Zn complex capable of promoting consumption of cell glucose as well as preparation and application
  • Luteolin-Zn complex capable of promoting consumption of cell glucose as well as preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 0.286g of luteolin and dissolve it in 100mL of absolute ethanol, vibrate and ultrasonically dissolve. The ratio of adding substances is 2:1 (luteolin: Zn 2+ =2:1) ​​zinc acetate, use 1mmol / L HCl to adjust the pH of the solution to 5, under constant temperature conditions of 60°C, reflux the water bath with magnetic stirring, and react for 5h to make it fully react to form a precipitate. Vacuum suction filtration, the obtained solid was repeatedly washed with absolute ethanol until the washing solution became colorless, and the powdered luteolin-Zn complex was obtained after vacuum drying.

Embodiment 2

[0023] Weigh 0.286g of luteolin and dissolve it in 100mL of absolute ethanol, vibrate and ultrasonically dissolve. The ratio of adding substances is 3:1 (luteolin: Zn 2+ =3:1) of zinc acetate, use 1mmol / L HCl to adjust the solution to pH=4, under the condition of constant temperature of 55°C, reflux the water bath with magnetic stirring, react for 6h, make it fully react to form a precipitate. Vacuum suction filtration, the obtained solid was repeatedly washed with absolute ethanol until the washing solution became colorless, and the powdered luteolin-Zn complex was obtained after vacuum drying.

Embodiment 3

[0025] Weigh 0.286g of luteolin and dissolve it in 100mL of absolute ethanol, vibrate and ultrasonically dissolve. The amount ratio of adding substances is 4:1 (luteolin: Zn 2+ =4:1) of zinc acetate, use 1mmol / L HCl to adjust the solution to pH=6, under the constant temperature condition of 65°C, reflux the water bath with magnetic stirring, and react for 4h to make it fully react to form a precipitate. Vacuum suction filtration, the obtained solid was repeatedly washed with absolute ethanol until the washing solution became colorless, and the powdered luteolin-Zn complex was obtained after vacuum drying.

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Abstract

The invention belongs to the technical field of natural product modifying medicines and discloses a luteolin-Zn complex capable of promoting the consumption of cell glucose as well as a preparation and application. The preparation method comprises the following steps: dissolving luteolin into absolute ethyl alcohol; adding zinc acetate and regulating the pH (Potential of Hydrogen) of a reaction solution to be 4 to 6 with hydrochloric acid; raising the temperature to 50 DEG C to 65 DEG C, and refluxing and stirring to react for 4h to 6h; separating, washing and drying a solid product to obtain luteolin-Zn complex solid powder. Compared with single luteolin, biological activities including a blood glucose lowering capability and the like of the luteolin-Zn complex are remarkably improved; the luteolin-Zn complex can be used for developing medicines capable of lowering blood glucose or health-care foods.

Description

technical field [0001] The invention belongs to the technical field of natural product modified medicines, and in particular relates to a luteolin-Zn complex for promoting glucose consumption in cells, as well as its preparation and application. Background technique [0002] Luteolin, also known as luteolin, xanthoflavin, foxglove, and huangshiling, is a natural weakly acidic tetrahydroxyflavonoid compound. Luteolin has a variety of physiological activities, such as antioxidant, antibacterial, antiviral, anti-inflammatory, antitumor, etc. It is widely used in medicine, health care and other fields, but its effect on lowering blood sugar is not obvious. [0003] The trace element Zn is an essential part of human metabolism, but it is easy to cause toxic side effects when supplemented alone. At present, the supplementation of trace elements mostly takes the form of complexes, such as morin-iron complexes, puerarin-Cu complexes, galangin-zinc complexes, etc. The method supple...

Claims

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Application Information

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IPC IPC(8): C07F3/06A61K33/30A61P3/10A23L33/165
CPCA23V2002/00A61K33/30C07F3/003C07F3/06A23V2200/328A23V2250/1642
Inventor 肖凯军龚斌朱良李华玉
Owner SOUTH CHINA UNIV OF TECH
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