A Single-Voxel Localized One-Dimensional Pure Chemical Shift NMR Spectroscopy Method

Abstract

An NMR (nuclear magnetic resonance) single voxel localization and one-dimensional pure chemical shift spectroscopy method comprises steps as follows: a to-be-detected sample is put in a detection cavity of a magnetic resonance imaging instrument; the position of the sample in the detection cavity is adjusted to ensure that an interested region is located at the center of the detection cavity for tuning, shimming and power and frequency correction; pai/2 non-selective radio-frequency pulse width of an excitation sample is measured, and measured pai/2 non-selective radio-frequency pulse can turn the magnetization vector from the Z-axis longitudinal direction to the XY transverse plane; a single voxel localization and one-dimensional pure chemical shift spectroscopy pulse sequence is imported to the imaging instrument, and a signal excitation module, a single voxel localization module and a pure chemical shift evolution module of the single voxel localization and one-dimensional pure chemical shift spectroscopy pulse sequence are opened; sequence parameters are set, and data sampling is executed; after data are sampled, sampled data are subjected to post-processing, post-processing includes two-dimensional Fourier transform, spectrogram indirect dimension projection and DMUSIC (decay multiple signal classification), and single voxel localization and one-dimensional pure chemical shift spectroscopy with high resolution and high signal-to-noise ratio is obtained.

Description

technical field [0001] The present invention relates to a nuclear magnetic resonance (NMR, Nuclear Magnetic Resonance) spectroscopy detection method, in particular to a single voxel determination method that can effectively simplify spectrogram information and contribute to the non-destructive detection of complex metabolites in biological tissues on a magnetic resonance imager. Domain one-dimensional pure chemical shift NMR spectroscopy method. Background technique [0002] NMR single voxel localization spectroscopy is a spectroscopic technique that can be used to non-destructively detect metabolites in biological tissues, and has important applications in animal research and clinical auxiliary diagnosis. The basic principle of magnetic resonance single-pixel localized spectroscopy is to use frequency-selective radio frequency pulses combined with corresponding spatially selected layer gradient fields to selectively excite nuclear magnetic resonance signals in a specific ti...

AI Technical Summary

Problems solved by technology

Due to the spectral peak splitting caused by J-coupling and the narrow chemical shift frequency range of the H-NMR spectrum, these two one-dimensional localized spectroscopy methods have the problem of spectral peak crowding in practical applications, resulting in the inability to analyze the spectral peak signal. make the right attribution

Especially for the detection of biological tissues containing complex metabolites, this peak crowding problem becomes more serious

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