An ultrasonic vibration type powder micro-filling nozzle
An ultrasonic vibration, micro-filling technology, applied in packaging, solid materials, transportation and packaging, etc., can solve the problems of powder that cannot be truly and well realized, cannot be further studied, and design parameters are not complete enough. The effect of high vibration transmission efficiency
Active Publication Date: 2019-06-07
杭州畅溪制药有限公司
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[0008] However, since the above-mentioned patents and publications are only in a preliminary research stage for the micro-control technology of powder, the above-mentioned parameters disclosed by it are only a rough and broad range, which are only suitable for laboratory experiments, and cannot be further investigated. Research
Due to the different physical properties of various powders, it has been found through research that the above design parameters are not only incomplete, but also cannot truly and well realize various powders, especially fine particles such as pharmaceuticals and poor fluidity, easy to agglomerate Micro-filling control of high-viscosity powder
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[0028] The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and embodiments.
[0029] Ultrasonic vibration type powder micro-filling nozzle of the present invention such as Figure 2 ~ Figure 3 As shown, it mainly includes a tubular nozzle housing 10, a filling channel 11 fixed in the nozzle housing 10, and an ultrasonic vibration source 14. The filling channel 11 can be used as Figure 4 , Figure 5 two different forms, Figure 4 in tubular form, Figure 5 In the form of a cavity, of course, other forms can also be adopted. Moreover, the structure of the filling flow channel 11 of the present invention is the same as that of the patent GB2472817 in that it also includes a cylindrical flow channel 1 and a conical flow channel 2. The cylindrical flow channel 1 is connected to the upper end of the conical flow channel 2, and the conical flow channel The inner diameter of the upper end of the shaped flo...
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The invention discloses an ultrasonic vibration type powder trace filling nozzle which comprises a filling runner and an ultrasonic vibration source installed on the filling runner. The inner diameter of a cylindrical runner of the filling runner is designed to be 6 mm to 10 mm, the inner diameter of an outlet in the lower end of a conical runner is designed to be 0.6 mm to 1.5 mm, the semi-cone angle of the conical runner is designed to be 6 degrees to 20 degrees, and the total height of the cylindrical runner and the conical runner is larger than the height of the cylindrical runner by 10 mm or above. According to the runners in the ultrasonic vibration type powder trace filling nozzle, key parameters and a specific parameter range in the whole runner design are completed, and control over medicament powder trace filling is better facilitated. In addition, due to the study on material selection of the runners, the flow speed of powder in the runners is more stable, and trace filling control is more accurate and effective; and the ultrasonic vibration type powder trace filling nozzle is particularly suitable for achieving precise quantification of trace powder conveying and filling in the production process of respiratory tract dry powder inhalation type medicaments (such as capsules and vesicae) and the like which is smaller than 20 mg per dose.
Description
technical field [0001] The invention relates to powder filling equipment, more specifically, to an ultrasonic vibration type powder micro-filling nozzle. Background technique [0002] In the pharmaceutical industry, powder materials as raw materials, intermediates, and final products are involved in all aspects of drug development and production. In order to improve the biopharmaceutical efficacy of drugs and the human body's absorption of poorly water-soluble drugs, the particle size of powder used in pharmaceutical preparations is usually as low as micron or nanometer. However, this kind of fine powder material will show very poor fluidity, which has caused great operational technical difficulties and waste of raw materials for drug development and production. Among them, the R&D and production of respiratory dry powder inhalation medicaments are an effective means to treat asthma, chronic obstructive pneumonia and other lung diseases, and their research and development a...
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IPC IPC(8): B65B1/08B65B1/30
CPCB65B1/08B65B1/30
Inventor 李宗奇陈岚陈东浩黄鹏孙梅生
Owner 杭州畅溪制药有限公司