A compound extracted from pseudo-fragrance-deficient tea vegetables, its preparation method and application

A technology for imitating teas and compounds lacking fragrance, which is applied in the field of medicine to achieve the effects of high separation efficiency, easy operation and simple separation process
CN106928064BActive Publication Date: 2019-08-16HENAN UNIV OF CHINESE MEDICINE

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HENAN UNIV OF CHINESE MEDICINE
Publication Date
2019-08-16

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Abstract

The invention relates to a compound extracted from isodon excisoides and a preparation method and application of the compound, and aims to effectively solve the problem of preparation of maceryatal B homolog in isodon excisoides. According to the technical scheme, the compound is white crystal, the molecular weight of the compound is 394, the molecular formula of the compound is C22H34O6, the unsaturation degree is 6, the structure is 1 alpha-acetyl-7 alpha, 14 beta, 20 alpha-trihydroxy-ent-kaurane-16-alkene-15-ketone, and the compound is a diterpene compound and is named as Excisoides D; the preparation method of the compound comprises the following steps: drying ground parts of the isodon excisoides, crushing, boiling with water for extraction, and extracting and purifying by using a macroreticular resin column, gel column chromatography, a Sephadex LH-20 column and semi-preparative HPLC (High Performance Liquid Chromatography), thereby obtaining the compound. The compound has an anti-tumor function, is easy to operate, high in separation speed, high in product purity and remarkable in economic and social benefit, and medicinal values of the isodon excisoides are developed.
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Description

technical field

[0001] The invention relates to the field of medicine, in particular to a compound extracted from pseudo-fragrance tea and its preparation method and application. Background technique

[0002] Fragrant tea plants are rich in resources, and most of them have the functions of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, antibacterial, and antitumor. Among the many medicinal plants, the Camellia genus is also considered to be the most promising plant for obtaining anti-tumor lead compounds. In recent years, a large number of new cytotoxic diterpenoids of Camellia have been discovered, and a group of compounds are used as Candidate anti-tumor compounds have entered the research and development stage, such as oridonin A, echinagenin A, carantenin, etc., and the sales of related traditional Chinese medicine products are also increasing year by year, such as Three Sisters Tablets (Xiye Fragrant tea vegetables), Donglingcao s...

Claims

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