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A composition for promoting coccidia oocyst value determination and its preparation method

A technology of composition and insect eggs, which is applied in the direction of drug combination, active ingredient of iodine compound, effective ingredient of hydroxyl compound, etc., can solve the problem of affecting the ability of sporozoites to bind to intestinal epithelial cells, and the inability of sporozoites to bind to intestinal epithelial cells , Unable to determine the value and discharge with intestinal contents, etc., to achieve the effect of increasing permeability, low cost, and improving utilization rate

Active Publication Date: 2020-07-03
TIANJIN HLINTE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the correct use of chicken coccidiosis live vaccine has achieved initial success, but the effect of chicken coccidiosis live vaccine is not very satisfactory due to the influence of many factors. The health status of chickens or flocks has declined; some feeds use anticoccidial drugs, which directly kill the coccidiostat vaccines; some use excessive doses so that the released sporozoites cannot combine with intestinal epithelial cells and cannot be valued Excreted with intestinal contents; some are affected by high temperature stress to accelerate the discharge of sporozoites or sporangia with intestinal contents, resulting in the failure of coccidia oocysts to combine with cells; with the improvement of breeding level, people have a better understanding of the characteristics of coccidia Some people understand that some factors that are unfavorable to coccidia are gradually eliminated, but at present, the ability to affect the binding degree of sporozoites and intestinal epithelial cells is a subject to be studied. combination

Method used

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  • A composition for promoting coccidia oocyst value determination and its preparation method
  • A composition for promoting coccidia oocyst value determination and its preparation method
  • A composition for promoting coccidia oocyst value determination and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A composition for promoting the fixed value of coccidian oocysts. The components and weights of the composition are respectively: pepsin 10kg, sodium salicylate 10kg, sodium bicarbonate 10kg, sorbitol 5kg and potassium iodide 10kg. A preparation method of a composition for improving the immune effect of a broiler coccidia vaccine, the steps of the preparation method are:

[0027] ⑴Weigh pepsin, sodium salicylate, sodium bicarbonate, sorbitol, potassium iodide according to the weight ratio, crush them and pass through a 200-mesh sieve;

[0028] (2) Put the sieved pepsin, sodium salicylate, sodium bicarbonate, sorbitol, and potassium iodide into a mixed vacuum drying oven at 45 degrees for 2 hours;

[0029] (3) Mix the dried pepsin, sodium salicylate, sodium bicarbonate, sorbitol, and potassium iodide into the mixing tank and mix evenly for 25 minutes to obtain a composition that promotes the value of coccidian oocysts Finished product.

Embodiment 2

[0031] A composition for promoting the fixed value of coccidian oocysts, the components and weights of the composition are respectively: pepsin 40kg, sodium salicylate 40kg, sodium bicarbonate 15kg, sorbitol 8kg and potassium iodide 20kg.

[0032] The steps of the preparation method are the same as in Example 1.

Embodiment 3

[0034] A composition for promoting the fixed value of coccidian oocysts. The components and weights of the composition are respectively: pepsin 30kg, sodium salicylate 30kg, sodium bicarbonate 10kg, sorbitol 30kg and potassium iodide 10kg.

[0035] The steps of the preparation method are the same as in Example 1.

[0036] Clinical application

[0037] 1. Description of the experiment: A broiler breeding group in Shandong took 120 1-day-old chicks from Aiweiyin broilers and divided them into four groups, each with 30 chicks, and kept them in an isolator. A is the Eimeria tenella group, the B group is the Eimeria tenella group + the present group, the C group is the poisonous Eimeria group, and the D group is the poisonous Eimeria group + the present group. Weigh one by one when grouping, and the size of each group is evenly distributed. The Eimeria tenella strain is a pure oocyst, and the Eimeria vulgaris oocyst is a pure oocyst; after oral administration, 2 copies of live coccidios...

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Abstract

The invention relates to a composition for promoting the colonization performance of coccidian oocysts and a preparation method thereof. The composition comprises, by weight, 10 to 40 parts of pepsin, 10 to 40 parts of sodium salicylate, 10 to 20 parts of sodium bicarbonate, 5 to 10 parts of sorbitol and 10 to 30 parts of potassium iodide. The composition is scientific and reasonable in composition, simple in preparation process, convenient to use and low in cost; and the composition can rapidly accelerate excystation of sporulated oocysts to release sporozoites, allows the sporozoites to rapidly enter intestinal epithelial cells for schizogenesis and gamogenesis so as to reduce loss of the sporozoites with intestinal contents, improves bonding between the sporozoites and cells, realizes rapid colonization of the sporozoites and enhances the utilization rate of a coccidium vaccine.

Description

Technical field [0001] The invention belongs to the field of veterinary biological products, in particular to a composition for promoting the definite value of coccidian oocysts and a preparation method thereof. Background technique [0002] At present, the correct use of live chicken coccidiosis vaccine has achieved initial success. Due to many factors, the effect of chicken coccidiosis live vaccine is not very satisfactory. Some strains are too virulent, leading to greater vaccine response and clinical death. The health status of chickens or chicken flocks has declined; some use anti-coccidial drugs in the feed, so that the coccidian vaccine is directly killed by the anti-coccidial drugs; some use excessive doses of sporozoites released from the intestinal epithelial cells that cannot be combined with intestinal epithelial cells. Excreted with the contents of the intestine; some are affected by high temperature stress to accelerate the expulsion of sporozoites or sporangia with...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/48A61P33/02A61K33/00A61K31/047A61K33/18A61K31/60
CPCA61K31/047A61K31/60A61K33/00A61K33/18A61K38/488A61K2300/00
Inventor 陈庆忠安同伟曹桂敏
Owner TIANJIN HLINTE BIOTECH CO LTD
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